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mutLBSgeneDB |
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| Gene summary for PAK7 |
 Gene summary |
| Basic gene Info. | Gene symbol | PAK7 |
| Gene name | p21 protein (Cdc42/Rac)-activated kinase 7 | |
| Synonyms | PAK5 | |
| Cytomap | UCSC genome browser: 20p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020341.3, NM_177990.2, | |
| Description | PAK-5PAK-7p21(CDKN1A)-activated kinase 7p21-activated kinase 5p21-activated kinase 7p21CDKN1A-activated kinase 7protein kinase PAK5serine/threonine-protein kinase PAK 7serine/threonine-protein kinase PAK7 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608038 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101349 | ||
| HPRD : 06423 | ||
| Vega : OTTHUMG00000031857 | ||
| Protein | UniProt: Q9P286 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PAK7 | |
| BioGPS: 57144 | ||
| Pathway | NCI Pathway Interaction Database: PAK7 | |
| KEGG: PAK7 | ||
| REACTOME: PAK7 | ||
| Pathway Commons: PAK7 | ||
| Context | iHOP: PAK7 | |
| ligand binding site mutation search in PubMed: PAK7 | ||
| UCL Cancer Institute: PAK7 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PAK7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V507 | D508G | COAD | 2 | V507 | D508G | GBM | 1 | Q715 | R717G | KIRC | 1 | E457 | S459T | LUAD | 1 | G529,E527 | G528S | LUAD | 1 | V463 | V463I | LUAD | 1 | M523 | M523I | SKCM | 1 | S585 | D586N | SKCM | 1 | V463 | V463G | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PAK7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M523 | M523I | 0.15848427 | Q715 | R717G | -1.075118 | V463 | V463G | -1.0441742 | S585 | D586N | -0.96885772 | V507 | D508G | -0.92307315 | E527 | G528S | -0.83000218 | G529 | G528S | -0.83000218 | E457 | S459T | -0.79268594 | V463 | V463I | -0.39888933 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PAK7 from PDB |
| PDB ID | PDB title | PDB structure | 2F57 | Crystal Structure Of The Human P21-Activated Kinase 5 |  |
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| Differential gene expression and gene-gene network for PAK7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PAK7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PAK7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PAK7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 23D | N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE | 2f57 | B | E457 V463 V507 M523 E527 G529 S585 Q715 |
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| Conservation information for LBS of PAK7 |
| Multiple alignments for Q9P286 in multiple species |
| LBS | AA sequence | # species | Species | A476 | TGKQVAVKKMD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A476 | TKQIVAVKRMN | 1 | Caenorhabditis elegans | E457 | FIKIGEGSTGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E457 | YKQIGEGSTGV | 1 | Caenorhabditis elegans | E524 | LWVVMEFLEGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E524 | LWVVMEFMEGG | 1 | Caenorhabditis elegans | E527 | VMEFLEGGALT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E527 | VMEFMEGGSLT | 1 | Caenorhabditis elegans | F525 | WVVMEFLEGGA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F525 | WVVMEFMEGGS | 1 | Caenorhabditis elegans | G456 | NFIKIGEGSTG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G456 | DYKQIGEGSTG | 1 | Caenorhabditis elegans | G529 | EFLEGGALTDI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G529 | EFMEGGSLTDI | 1 | Caenorhabditis elegans | I455 | DNFIKIGEGST | 2 | Mus musculus, Rattus norvegicus | I455 | ANFIKIGEGST | 1 | Homo sapiens | I455 | TDYKQIGEGST | 1 | Caenorhabditis elegans | L526 | VVMEFLEGGAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L526 | VVMEFMEGGSL | 1 | Caenorhabditis elegans | L575 | KSDSILLTSDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L575 | KSDSILLKRDG | 1 | Caenorhabditis elegans | M523 | ELWVVMEFLEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M523 | ELWVVMEFMEG | 1 | Caenorhabditis elegans | Q715 | VPLMRQYR--- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q715 | APLLLQLQGNT | 1 | Caenorhabditis elegans | S585 | GRIKLSDFGFC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S585 | GTVKLTDFGFC | 1 | Caenorhabditis elegans | V463 | GSTGIVCIATE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V463 | GSTGVVEAAYK | 1 | Caenorhabditis elegans | V507 | HHDNVVDMYNS | 2 | Mus musculus, Rattus norvegicus | V507 | HHDNVVDMYSS | 1 | Homo sapiens | V507 | QHPNIVRFFSS | 1 | Caenorhabditis elegans |
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