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mutLBSgeneDB |
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| Gene summary for CAMK1G |
 Gene summary |
| Basic gene Info. | Gene symbol | CAMK1G |
| Gene name | calcium/calmodulin-dependent protein kinase IG | |
| Synonyms | CLICK3|CLICKIII|VWS1|dJ272L16.1 | |
| Cytomap | UCSC genome browser: 1q32.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020439.2, | |
| Description | CLICK IIIcaM kinase I gammacaM kinase IGcaM-KI gammacaMK-like CREB kinase IIIcaMKI gammacaMKIGcalcium/calmodulin-dependent protein kinase type 1G | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614994 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000008118 | ||
| HPRD : 10807 | ||
| Vega : OTTHUMG00000036361 | ||
| Protein | UniProt: Q96NX5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CAMK1G | |
| BioGPS: 57172 | ||
| Pathway | NCI Pathway Interaction Database: CAMK1G | |
| KEGG: CAMK1G | ||
| REACTOME: CAMK1G | ||
| Pathway Commons: CAMK1G | ||
| Context | iHOP: CAMK1G | |
| ligand binding site mutation search in PubMed: CAMK1G | ||
| UCL Cancer Institute: CAMK1G | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CAMK1G |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L283 | T281R | BRCA | 1 | T163 | M161T | COAD | 1 | K73 | K74N | LUAD | 1 | L29 | E27K | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CAMK1G |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L283 | T281R | 0.58600676 | T163 | M161T | -1.6363661 | K73 | K74N | -1.0902287 | L29 | E27K | -0.30850277 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CAMK1G from PDB |
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| Differential gene expression and gene-gene network for CAMK1G |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CAMK1G |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CAMK1G |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB08009 | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CAMK1G go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | J60 | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | 2jam | A | L29 | J60 | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | 2jam | B | L29 |
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| Conservation information for LBS of CAMK1G |
| Multiple alignments for Q96NX5 in multiple species |
| LBS | AA sequence | # species | Species | A50 | TGKLFALKCIK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D164 | KIMITDFGLSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D85 | IVTLEDIYEST | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E88 | LEDIYESTTHY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H284 | GNTALHRDIYP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I86 | VTLEDIYESTT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K52 | KLFALKCIKKS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K73 | EIAVLKRIKHE | 2 | Mus musculus, Rattus norvegicus | K73 | EIAVLKKIKHE | 1 | Homo sapiens | L150 | KPENLLYLTPE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L283 | DGNTALHRDIY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L29 | IFMEVLGSGAF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L99 | YLVMQLVSGGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M97 | HYYLVMQLVSG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N18 | KKQTTNIRKTF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q98 | YYLVMQLVSGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R285 | NTALHRDIYPS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S89 | EDIYESTTHYY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T16 | SWKKQTTNIRK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T163 | SKIMITDFGLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T17 | WKKQTTNIRKT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V100 | LVMQLVSGGEL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V37 | GAFSEVFLVKQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y87 | TLEDIYESTTH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y93 | ESTTHYYLVMQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y94 | STTHYYLVMQL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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