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mutLBSgeneDB |
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| Gene summary for PTGDS |
 Gene summary |
| Basic gene Info. | Gene symbol | PTGDS |
| Gene name | prostaglandin D2 synthase 21kDa (brain) | |
| Synonyms | L-PGDS|LPGDS|PDS|PGD2|PGDS|PGDS2 | |
| Cytomap | UCSC genome browser: 9q34.2-q34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000954.5, | |
| Description | PGD2 synthasebeta-trace proteincerebrin-28glutathione-independent PGD synthaseglutathione-independent PGD synthetaselipocalin-type prostaglandin D synthaselipocalin-type prostaglandin-D synthaseprostaglandin D synthaseprostaglandin-D2 synthasepro | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176803 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000107317 | ||
| HPRD : 08904 | ||
| Vega : OTTHUMG00000020957 | ||
| Protein | UniProt: P41222 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTGDS | |
| BioGPS: 5730 | ||
| Pathway | NCI Pathway Interaction Database: PTGDS | |
| KEGG: PTGDS | ||
| REACTOME: PTGDS | ||
| Pathway Commons: PTGDS | ||
| Context | iHOP: PTGDS | |
| ligand binding site mutation search in PubMed: PTGDS | ||
| UCL Cancer Institute: PTGDS | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001516 | prostaglandin biosynthetic process | 20667974 |
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| Ligand binding site mutations for PTGDS |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S67 | V69M | KIRC | 1 | W112 | H111N | LUAD | 1 | W112 | H111Y | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PTGDS |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W112 | H111N | -1.2130203 | W112 | H111Y | -0.8114319 | S67 | V69M | -0.46013459 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PTGDS from PDB |
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| Differential gene expression and gene-gene network for PTGDS |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PTGDS |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PTGDS |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PTGDS go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PWZ | (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1- YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC ACID | 4imo | A | S67 W112 | PWZ | (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-HYDROXYOCT-1-EN-1- YL]-2-OXABICYCLO[2.2.1]HEPT-6-YL}HEPT-5-ENOIC ACID | 4imo | A | W112 |
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| Conservation information for LBS of PTGDS |
| Multiple alignments for P41222 in multiple species |
| LBS | AA sequence | # species | Species | F143 | GPGQDFRMATL | 3 | Mus musculus, Rattus norvegicus, Bos taurus | F143 | GPGEDFRMATL | 1 | Homo sapiens | F143 | GLGQDFHMATL | 1 | Canis lupus familiaris | G140 | GTKGPGQDFRM | 2 | Mus musculus, Rattus norvegicus | G140 | GSKGPGEDFRM | 1 | Homo sapiens | G140 | GSKGLGQDFHM | 1 | Canis lupus familiaris | G140 | GVRGPGQDFRM | 1 | Bos taurus | P139 | QGSKGPGEDFR | 1 | Homo sapiens | P139 | RGTKGPGQDFR | 1 | Mus musculus | P139 | KGTKGPGQDFR | 1 | Rattus norvegicus | P139 | AGSKGLGQDFH | 1 | Canis lupus familiaris | P139 | EGVRGPGQDFR | 1 | Bos taurus | S109 | SYSYRSPHWGS | 1 | Homo sapiens | S109 | HYTYSSPHSGS | 1 | Mus musculus | S109 | QYTYNSPHWGS | 1 | Rattus norvegicus | S109 | CYSYTSPHWGS | 1 | Canis lupus familiaris | S109 | CYSYTSPHWSS | 1 | Bos taurus | S45 | LGRWYSAGLAS | 2 | Mus musculus, Rattus norvegicus | S45 | LGRWFTSGLAS | 2 | Canis lupus familiaris, Bos taurus | S45 | LGRWFSAGLAS | 1 | Homo sapiens | S67 | LSMCKSVVAPA | 2 | Homo sapiens, Bos taurus | S67 | LYMCKTVVAPS | 1 | Mus musculus | S67 | LFMCQTVVAPS | 1 | Rattus norvegicus | S67 | LSMCMSVVAPT | 1 | Canis lupus familiaris | S81 | GLNLTSTFLRK | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | W112 | YRSPHWGSTYS | 1 | Homo sapiens | W112 | YSSPHSGSIHS | 1 | Mus musculus | W112 | YNSPHWGSFHS | 1 | Rattus norvegicus | W112 | YTSPHWGSTHD | 1 | Canis lupus familiaris | W112 | YTSPHWSSTHE | 1 | Bos taurus | W54 | ASNSSWFREKK | 3 | Mus musculus, Rattus norvegicus, Canis lupus familiaris | W54 | ASNSSWLREKK | 1 | Homo sapiens | W54 | ASNSSWFLEKK | 1 | Bos taurus | Y107 | PGCYSYTSPHW | 2 | Canis lupus familiaris, Bos taurus | Y107 | LGSYSYRSPHW | 1 | Homo sapiens | Y107 | PGHYTYSSPHS | 1 | Mus musculus | Y107 | PGQYTYNSPHW | 1 | Rattus norvegicus | Y116 | HWGSTYSVSVV | 1 | Homo sapiens | Y116 | HSGSIHSVSVV | 1 | Mus musculus | Y116 | HWGSFHSLSVV | 1 | Rattus norvegicus | Y116 | HWGSTHDVWVV | 1 | Canis lupus familiaris | Y116 | HWSSTHEVSVA | 1 | Bos taurus | Y149 | RMATLYSRTQT | 2 | Homo sapiens, Mus musculus | Y149 | RMATLYSRAQL | 1 | Rattus norvegicus | Y149 | HMATLYSRTQT | 1 | Canis lupus familiaris | Y149 | RMATLYSRSQN | 1 | Bos taurus |
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