mutLBSgeneDB |
Gene summary for NDRG2 |
![]() |
Basic gene Info. | Gene symbol | NDRG2 |
Gene name | NDRG family member 2 | |
Synonyms | SYLD | |
Cytomap | UCSC genome browser: 14q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001282211.1, NM_001282212.1,NM_001282213.1,NM_001282214.1,NM_001282215.1, NM_001282216.1,NM_016250.2,NM_201535.1,NM_201536.1, NM_201537.1,NM_201538.1,NM_201539.1,NM_201540.1, NM_201541.1, | |
Description | N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1protein NDRG2syld709613 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 605272 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165795 | ||
HPRD : 17630 | ||
Vega : OTTHUMG00000029619 | ||
Protein | UniProt: Q9UN36 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NDRG2 | |
BioGPS: 57447 | ||
Pathway | NCI Pathway Interaction Database: NDRG2 | |
KEGG: NDRG2 | ||
REACTOME: NDRG2 | ||
Pathway Commons: NDRG2 | ||
Context | iHOP: NDRG2 | |
ligand binding site mutation search in PubMed: NDRG2 | ||
UCL Cancer Institute: NDRG2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for NDRG2 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | Y316 | G315S | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for NDRG2 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y316 | G315S | -0.67066458 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for NDRG2 |
![]() |
![]() |
Top |
Top |
Phenotype information for NDRG2 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0086543 | Cataract | 1 | Biomarker |
umls:C0009375 | Colonic Neoplasms | 1 | Biomarker |
umls:C0007787 | Ischemic Attack, Transient | 1 | Biomarker |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for NDRG2 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of NDRG2 |
![]() |
LBS | AA sequence | # species | Species | Y316 | LQGMGYMASSC | 4 | Homo sapiens, Mus musculus, Bos taurus, Pan troglodytes | Y316 | VQGMGYMASSC | 2 | Xenopus tropicalis, Rattus norvegicus | Y316 | IQGMGYMASSC | 1 | Danio rerio |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |