mutLBSgeneDB |
Gene summary for TSHZ3 |
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Basic gene Info. | Gene symbol | TSHZ3 |
Gene name | teashirt zinc finger homeobox 3 | |
Synonyms | TSH3|ZNF537 | |
Cytomap | UCSC genome browser: 19q12 | |
Type of gene | protein-coding | |
RefGenes | NM_020856.2, | |
Description | teashirt 3teashirt family zinc finger 3teashirt homolog 3zinc finger protein 537 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614119 | |
HGNC : HGNC | ||
Ensembl : ENSG00000121297 | ||
HPRD : 18351 | ||
Vega : OTTHUMG00000150184 | ||
Protein | UniProt: Q63HK5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSHZ3 | |
BioGPS: 57616 | ||
Pathway | NCI Pathway Interaction Database: TSHZ3 | |
KEGG: TSHZ3 | ||
REACTOME: TSHZ3 | ||
Pathway Commons: TSHZ3 | ||
Context | iHOP: TSHZ3 | |
ligand binding site mutation search in PubMed: TSHZ3 | ||
UCL Cancer Institute: TSHZ3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 19343227 |
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Ligand binding site mutations for TSHZ3 |
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LBS | AAchange of nsSNV | Cancer type | # samples | C219 | C219Y | COAD | 1 | H238 | H238Q | KIRC | 1 | H238 | H238L | KIRC | 1 | C219 | A221T | LUAD | 1 | H232 | V231M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TSHZ3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H238 | H238Q | -1.2180095 | C219 | C219Y | -1.0679621 | H232 | V231M | -0.97719461 | H238 | H238L | -0.6758663 | C219 | A221T | -0.31621185 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for TSHZ3 |
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Phenotype information for TSHZ3 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TSHZ3 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of TSHZ3 |
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LBS | AA sequence | # species | Species | C216 | ASKFRCKDCSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C219 | FRCKDCSAAYD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H232 | VELTVHMNETG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H238 | MNETGHYRDDN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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