mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for STIM2

Gene summary

Basic gene Info.	Gene symbol	STIM2
	Gene name	stromal interaction molecule 2
	Synonyms	-
	Cytomap	UCSC genome browser: 4p15.2
	Type of gene	protein-coding
	RefGenes	NM_001169117.1, NM_001169118.1,NM_020860.3,
	Description	-
	Modification date	20141222
dbXrefs	MIM : 610841
	HGNC : HGNC
	Ensembl : ENSG00000109689
	HPRD : 11609
	Vega : OTTHUMG00000097805
Protein	UniProt: Q9P246 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_STIM2
	BioGPS: 57620
Pathway	NCI Pathway Interaction Database: STIM2
	KEGG: STIM2
	REACTOME: STIM2
	Pathway Commons: STIM2
Context	iHOP: STIM2
	ligand binding site mutation search in PubMed: STIM2
	UCL Cancer Institute: STIM2
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0032237	activation of store-operated calcium channel activity	17905723
GO:0051928	positive regulation of calcium ion transport	17905723
GO:0070588	calcium ion transmembrane transport	16860747

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Ligand binding site mutations for STIM2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
D80	Q78P	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for STIM2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
D80	Q78P	-1.0464823

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STIM2 from PDB

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Differential gene expression and gene-gene network for STIM2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of STIM2 and the right PPI network was created from samples without mutations in the LBS of STIM2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for STIM2

Gene level disease information (DisGeNet)