mutLBSgeneDB |
Gene summary for PLEKHA4 |
![]() |
Basic gene Info. | Gene symbol | PLEKHA4 |
Gene name | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | |
Synonyms | PEPP1 | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001161354.1, NM_020904.2, | |
Description | PEPP-1PH domain-containing family A member 4phosphoinositol 3-phosphate binding protein-1phosphoinositol 3-phosphate-binding PH domain protein 1phosphoinositol 3-phosphate-binding protein 1pleckstrin homology domain-containing family A member 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607769 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105559 | ||
HPRD : 09683 | ||
Vega : OTTHUMG00000183329 | ||
Protein | UniProt: Q9H4M7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PLEKHA4 | |
BioGPS: 57664 | ||
Pathway | NCI Pathway Interaction Database: PLEKHA4 | |
KEGG: PLEKHA4 | ||
REACTOME: PLEKHA4 | ||
Pathway Commons: PLEKHA4 | ||
Context | iHOP: PLEKHA4 | |
ligand binding site mutation search in PubMed: PLEKHA4 | ||
UCL Cancer Institute: PLEKHA4 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for PLEKHA4 |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | R129 | M128T | COAD | 1 | R129 | G127C | LUAD | 1 | D65 | D65Y | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for PLEKHA4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R129 | M128T | -1.3951867 | R129 | G127C | -0.74014655 | D65 | D65Y | -0.49165252 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for PLEKHA4 |
![]() |
![]() |
Top |
Top |
Phenotype information for PLEKHA4 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for PLEKHA4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB01863 | Inositol 1,3,4,5-Tetrakisphosphate | Small molecule | ![]() |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of PLEKHA4 |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |