mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PTPN1
Gene summary
Basic gene Info.Gene symbolPTPN1
Gene nameprotein tyrosine phosphatase, non-receptor type 1
SynonymsPTP1B
CytomapUCSC genome browser: 20q13.1-q13.2
Type of geneprotein-coding
RefGenesNM_001278618.1,
NM_002827.3,
Descriptionprotein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1Btyrosine-protein phosphatase non-receptor type 1
Modification date20141222
dbXrefs MIM : 176885
HGNC : HGNC
Ensembl : ENSG00000196396
HPRD : 01477
Vega : OTTHUMG00000032729
ProteinUniProt: P18031
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTPN1
BioGPS: 5770
PathwayNCI Pathway Interaction Database: PTPN1
KEGG: PTPN1
REACTOME: PTPN1
Pathway Commons: PTPN1
ContextiHOP: PTPN1
ligand binding site mutation search in PubMed: PTPN1
UCL Cancer Institute: PTPN1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0030100regulation of endocytosis21135139
GO:0030968endoplasmic reticulum unfolded protein response22169477
GO:0035335peptidyl-tyrosine dephosphorylation21135139


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Ligand binding site mutations for PTPN1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F196F196VCOAD1
R254F254LHNSC1
N44G44RLUAD1
W291E289KLUAD1
F182R184WSKCM1
W291M291VSTAD1
K292D294YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PTPN1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F196F196V-1.1413971
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PTPN1 from PDB

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Differential gene expression and gene-gene network for PTPN1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PTPN1 and the right PPI network was created from samples without mutations in the LBS of PTPN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PTPN1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0011860Diabetes Mellitus, Type 223Biomarker, GeneticVariation
umls:C0079731Lymphoma, B-Cell2Biomarker
umls:C0019829Hodgkin Disease1Biomarker
umls:C0025063Mediastinal Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PTPN1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|vet_approvedDB01133TiludronateSmall molecule
ExperimentalDB017343-(Oxalyl-Amino)-Naphthalene-2-Carboxylic AcidSmall molecule
ExperimentalDB01769Double Oxidized CysteineSmall molecule
ExperimentalDB01820Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-NapthylalaniamideSmall molecule
ExperimentalDB02014Compound 9Small molecule
ExperimentalDB020722-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic AcidSmall molecule
ExperimentalDB022593-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-AmideSmall molecule
ExperimentalDB02420[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,Small molecule
ExperimentalDB024362-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic AcidSmall molecule
ExperimentalDB02615Compound 19Small molecule
ExperimentalDB02620Sp7343-Sp7964Small molecule
ExperimentalDB026222-(Oxalyl-Amino)-Benzoic AcidSmall molecule
ExperimentalDB02651{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)Small molecule
ExperimentalDB02662Novo Nordisk a/S CompoundSmall molecule
ExperimentalDB02784N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic AcidSmall molecule
ExperimentalDB028277-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall molecule
ExperimentalDB02977PNU177836Small molecule
ExperimentalDB031022-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall molecule
ExperimentalDB03154{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic AcidSmall molecule
ExperimentalDB033113-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-AmideSmall molecule
ExperimentalDB034834-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric AcidSmall molecule
ExperimentalDB03557N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic AcidSmall molecule
ExperimentalDB03661Cysteinesulfonic AcidSmall molecule
ExperimentalDB036702-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic AcidSmall molecule
ExperimentalDB037144-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric AcidSmall molecule
ExperimentalDB03982Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-BenzoicacidSmall molecule
ExperimentalDB040016-(Oxalyl-Amino)-1h-Indole-5-Carboxylic AcidSmall molecule
ExperimentalDB04088N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)Small molecule
ExperimentalDB041423-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid DimethylamideSmall molecule
ExperimentalDB04204[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic AcidSmall molecule
ExperimentalDB04285{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic AcidSmall molecule
ExperimentalDB045252-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic AcidSmall molecule
ExperimentalDB048001-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACIDSmall molecule
InvestigationalDB05506ISIS 113715Small molecule
ExperimentalDB068294-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB068873(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTERSmall molecule
ExperimentalDB071304-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB071345-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall molecule
ExperimentalDB071974-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB07263[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acidSmall molecule
ExperimentalDB072895-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB072952-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACIDSmall molecule
ExperimentalDB072983-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB074804-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZENSmall molecule
ExperimentalDB07651N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDESmall molecule
ExperimentalDB077193(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTERSmall molecule
ExperimentalDB077305-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDESmall molecule
ExperimentalDB080015-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACIDSmall molecule
ExperimentalDB08003ISOTHIAZOLIDINONE ANALOGSmall molecule
ExperimentalDB081474-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acidSmall molecule
ExperimentalDB08371PARA-(BENZOYL)-PHENYLALANINESmall molecule
ExperimentalDB083976-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACIDSmall molecule
ExperimentalDB08549(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTERSmall molecule
ExperimentalDB085915-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall molecule
ExperimentalDB085931,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDESmall molecule
ExperimentalDB08783(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PTPN1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
BPM4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN1aaxAF182
TPI4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID1bzcAF182
PIC6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLICACID1bzjAF182
OAI6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID1c83AF182
7613-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID1c84AF182
OBA2-(OXALOAMINO)BENZOIC ACID1c85AF182
OPA2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID1c86AF182
OPA2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID1c87AF182
OTA2-(OXALOAMINO)-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID1c88AF182
8785-IODO-2-(OXALOAMINO)BENZOIC ACID1ecvAF182
IIIPeptide ligand (ALA,ASP,PHE,TYR,LEU,ILE,PRO)1eenAF182
IIIPeptide ligand (LEU,GLU,PHE,TYR,MET,ASP,TYR,GLU,NH2)1eeoAF182
IIIPeptide ligand (THR,ASP,TYR,TYR,ARG)1g1gAF182
INX2-(CARBOXYMETHOXY)-5-[(2S)-2-({(2S)-2-[(3-CARBOXYPROPANOYL)AMINO] -3-PHENYLPROPANOYL}AMINO)-3-OXO-3-(PENTYLAMINO)PROPYL]BENZOIC ACID1g7gAF182
COL2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID1gfyAF182
TBH5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID1jf7BF182
FNP[[7-[DIFLUORO(PHOSPHONO)METHYL]NAPHTHALEN-2-YL]-DIFLUOROMETHYL]PHOSPHONIC ACID1kakAF182
FEP[[4-[4-[4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL]BUTYL]PHENYL]-DIFLUOROMETHYL]PHOSPHONIC ACID1kavAF182
DBD7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID1l8gAF182
FG1N-[4-(2-{2-[3-(2-BROMO-ACETYLAMINO)-PROPIONYLAMINO]-3-HYDROXY-PROPIONYLAMINO}-ETHYL)-PHENYL]-OXALAMIC ACID1nweAF182
IIIPeptide ligand (ACE,ASP,GLU,TYR,LEU)1pttAF182
PTRO(4)-PHOSPHO-L-TYROSINE1ptvAF182
PTRO(4)-PHOSPHO-L-TYROSINE1ptyAF182
SNAN-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID1pxhAF182
335[4-(2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL](DIFLUORO)METHYLPHOSPHONIC ACID1q6jAF182
P27{[2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-(3,4-DIFLUOROPHENYL)PROPANE-1,3-DIYL]BIS[4,1-PHENYLENE(DIFLUOROMETHYLENE)]}BIS(PHOSPHONIC ACID)1q6mAF182
LO1ACTIVE SITE INHIBITOR OF PTP1B1waxAF182
9823-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLICACID2azrAF182
5986-[(1-BENZYLSULFONYLPIPERIDIN-4-YL)AMINO]-3-(CARBOXYMETHYLOXY)THIENO[3,2-B][1]BENZOTHIOLE-2-CARBOXYLIC ACID2b07AF182
T1D5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE2bgdAF182
T2DINHIBITOR OF PROTEIN-TYROSINE PHOSPHATASE 1B2bgeAF182
IZDISOTHIAZOLIDINONE ANALOG2cm7AF182
F165-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE2cm8AF182
F20ISOTHIAZOLIDINONE ANALOG2cmaAF182
F17ISOTHIAZOLIDANONE ANALOGUE2cmbAF182
DFMN-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE2cmcAF182
DFJDIFLUOROMETHYLPHOSPHONIC ACID ANALOG2cneAF182
F32(5S)-5-{4-[(2S)-2-(1H-BENZIMIDAZOL-2-YL)-2-(1,3-BENZOTHIAZOL-2-YLAMINO)ETHYL]PHENYL}ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE2cnfAF182
IZEISOTHIAZOLIDINONE ANALOG2cngAF182
IZBISOTHIAZOLIDINONE ANALOG2cnhAF182
1C23(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER2f6tAF182
SK2(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER2f6vAF182
UN31-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID2f6wAF182
ENT3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER2f6yAF182
6944-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID2h4gAF182
5094-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID2h4kAF182
5124-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID2hb1AF182
902{[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID2nt7AF182
5215-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE2ntaAF182
5275-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID2qbpAF182
4B34-BROMO-3-(CARBOXYMETHOXY)-5-{3-[(3,3,5,5-TETRAMETHYLCYCLOHEXYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC ACID2qbqAF182
9105-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID2qbrAF182
0244-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID2qbsAF182
IZ1N-[(1S)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-(4-PHENYL-1H-IMIDAZOLYL)ETHYL]-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE2veuAF182
IZ2N-[(1S)-1-(4-BENZYL-1H-IMIDAZOL-2-YL)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}ETHYL]-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE2vevAF182
IZ33-FLUORO-N-[(1S)-1-[4-[(2-FLUOROPHENYL)METHYL]IMIDAZOL-2-YL]-2-[4-[(5S)-1,1,3-TRIOXO-1,2-THIAZOLIDIN-5-YL]PHENYL]ETHYL]BENZENESULFONAMIDE2vewAF182
IZ4N-{(1S)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[(4R)-4-(2-PHENYLETHY4,5-DIHYDRO-1H-IMIDAZOL-2-YL]ETHYL}-3-FLUOROBENZENESULFONAMIDE2vexAF182
IZ5N-{(1S)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[4-(3-PHENYLPROPYL)-1IMIDAZOL-2-YL]ETHYL}-3-FLUOROBENZENESULFONAMIDE2veyAF182
35B4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[CYCLOHEXYL(METHYLCARBAMOYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC ACID2zmmAF182
4104-BROMO-3-(CARBOXYMETHOXY)-5-{3-[CYCLOHEXYL(PHENYLCARBONYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC ACID2zn7AF182
IIIPeptide ligand (ASP,ALA,ASP,GLU,TYR,LEU)3i7zAF182
VO4VANADATE(3-)3qkqAF182
1CG[(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL) SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID4i8nAF182
IIIPeptide ligand (GLN,TYR,GLN)3zmpAF182
IIIPeptide ligand (GLU,ALA,GLN,TYR,GLN,PRO)3zmqAF182
IIIPeptide ligand (GLY,PRO,LEU,PTR,ASP,GLU)4zrtAF182
C0A3-BROMO-4-[DIFLUORO(PHOSPHONO)METHYL]-N-METHYL-NALPHA- (METHYLSULFONYL)-L-PHENYLALANINAMIDE4y14AF182
C0A3-BROMO-4-[DIFLUORO(PHOSPHONO)METHYL]-N-METHYL-NALPHA- (METHYLSULFONYL)-L-PHENYLALANINAMIDE4y14BF182
IIIPeptide ligand (GLU,THR,ASP,TYR,TYR,ARG)1g1fAF182 R254
IIIPeptide ligand (THR,ASP,TYR,TYR,ARG,LYS,GLY)1g1hAF182 R254
2345-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID1q1mAF182 R254
429COMPOUND 201qxkAF182 R254
IX15-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID1xboAF182 R254
IZFISOTHIAZOLIDINONE ANALOG2cniAF182 R254
UN5TETRAHYDROISOQUINOLINE (TIQ) DERIV. 10I2f6zAF182 R254
UN6[3-[3-OXO-3-[[3-(SULFOAMINO)PHENYL]METHYLAMINO]PROPYL]PHENYL]SULFAMIC ACID2f70AF182 R254
UN73-[3-(3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4,-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3-OXO-PROPYL]-BENZOIC ACID2f71AF182 R254
8923-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE1t49AF196
FRJ3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE1t4jAF196
BB33-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID DIMETHYLAMIDE1t48AF196 W291 K292
IIIPeptide ligand (GLU,PRO,GLN,TYR,GLN,PRO,GLY,GLU,ASN)3zmpBN44 F182
BPM4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN1aaxAR254
5153-({5-[(N-ACETYL-3-{4-[(CARBOXYCARBONYL)(2-CARBOXYPHENYL)AMINO]-1-NAPHTHYL}-L-ALANYL)AMINO]PENTYL}OXY)-2-NAPHTHOIC ACID1nnyAR254
4182-{4-[2-(S)-ALLYLOXYCARBONYLAMINO-3-{4-[(2-CARBOXY-PHENYL)-OXALYL-AMINO]-PHENYL}-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER1ph0AR254
PTRO(4)-PHOSPHO-L-TYROSINE1ptyAR254
9412-(4-{2-TERT-BUTOXYCARBONYLAMINO-2-[4-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-BUTYLCARBAMOYL]-ETHYL}-PHENOXY)-MALONIC ACID1pynAR254


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Conservation information for LBS of PTPN1
Multiple alignments for P18031 in multiple species
LBSAA sequence# speciesSpecies
A189VPESPASFLNF4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
A217VVHCSAGIGRS4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
A27DIRHEASDFPC4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
C215PVVVHCSAGIG2Homo sapiens, Gallus gallus
C215PIVVHCSAGIG2Mus musculus, Rattus norvegicus
D181YTTWPDFGVPE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D29RHEASDFPCKV2Gallus gallus, Mus musculus
D29RHEASDFPCRV1Homo sapiens
D29RHEASDFPCRI1Rattus norvegicus
D48RNRYRDVSPFD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E129YWPQKEEKEMI1Homo sapiens
E129YWPRKEEKEMF1Gallus gallus
E129YWPQQEEKEMV1Mus musculus
E129YWPQKEEKEMV1Rattus norvegicus
E130WPQKEEKEMIF1Homo sapiens
E130WPRKEEKEMFF1Gallus gallus
E130WPQQEEKEMVF1Mus musculus
E130WPQKEEKEMVF1Rattus norvegicus
E200LFKVRESGSLS3Homo sapiens, Mus musculus, Rattus norvegicus
E200LFKVRESGSLN1Gallus gallus
E276YLAVIEGAKFI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F182TTWPDFGVPES4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F196FLNFLFKVRES4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F280IEGAKFIMGDS3Homo sapiens, Mus musculus, Rattus norvegicus
F280IEGAKFIMGDA1Gallus gallus
F52RDVSPFDHSRI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G218VHCSAGIGRSG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G220CSAGIGRSGTF4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G259RRFRMGLIQTA2Mus musculus, Rattus norvegicus
G259RKFRMGLIQTA1Homo sapiens
G259RKYRMGLIQTA1Gallus gallus
G277LAVIEGAKFIM4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I219HCSAGIGRSGT4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
K120EKGSLKCAQYW3Homo sapiens, Mus musculus, Rattus norvegicus
K120EKGSIKCAQYW1Gallus gallus
K197LNFLFKVRESG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
K279VIEGAKFIMGD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
K292VQDQWKELSHE2Homo sapiens, Rattus norvegicus
K292VQEQWKELSNE1Gallus gallus
K292VQDQWKELSRE1Mus musculus
K41KLPKNKNRNRY3Homo sapiens, Mus musculus, Rattus norvegicus
K41KHPRNKNRNRY1Gallus gallus
L119MEKGSLKCAQY3Homo sapiens, Mus musculus, Rattus norvegicus
L119MEKGSIKCAQY1Gallus gallus
L192SPASFLNFLFK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M14Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M258MRRFRMGLIQT2Mus musculus, Rattus norvegicus
M258MRKFRMGLIQT1Homo sapiens
M258MRKYRMGLIQT1Gallus gallus
N193PASFLNFLFKV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
N44KNKNRNRYRDV3Homo sapiens, Mus musculus, Rattus norvegicus
N44RNKNRNRYRDV1Gallus gallus
Q262RMGLIQTADQL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Q266IQTADQLRFSY4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R221SAGIGRSGTFC4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R24IYQDIRHEASD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R254VLLEMRRFRMG2Mus musculus, Rattus norvegicus
R254VLLEMRKFRMG1Homo sapiens
R254VLLEMRKYRMG1Gallus gallus
R45NKNRNRYRDVS4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R47NRNRYRDVSPF4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
S118IMEKGSLKCAQ2Mus musculus, Rattus norvegicus
S118VMEKGSLKCAQ1Homo sapiens
S118VMEKGSIKCAQ1Gallus gallus
S216VVVHCSAGIGR2Homo sapiens, Gallus gallus
S216IVVHCSAGIGR2Mus musculus, Rattus norvegicus
S222AGIGRSGTFCL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
S28IRHEASDFPCR2Homo sapiens, Rattus norvegicus
S28IRHEASDFPCK2Gallus gallus, Mus musculus
T263MGLIQTADQLR4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V49NRYRDVSPFDH4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W179FHYTTWPDFGV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W291SVQDQWKELSH2Homo sapiens, Rattus norvegicus
W291SVQEQWKELSN1Gallus gallus
W291SVQDQWKELSR1Mus musculus
Y20SWAAIYQDIRH2Homo sapiens, Gallus gallus
Y20NWAAIYQDIRH2Mus musculus, Rattus norvegicus
Y46KNRNRYRDVSP4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus


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