mutLBSgeneDB |
Gene summary for MARK4 |
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Basic gene Info. | Gene symbol | MARK4 |
Gene name | MAP/microtubule affinity-regulating kinase 4 | |
Synonyms | MARK4L|MARK4S|MARKL1|MARKL1L|PAR-1D | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001199867.1, NM_031417.3, | |
Description | MAP/microtubule affinity-regulating kinase like 1MARK4 serine/threonine protein kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 606495 | |
HGNC : HGNC | ||
Ensembl : ENSG00000007047 | ||
HPRD : 09402 | ||
Vega : OTTHUMG00000181769 | ||
Protein | UniProt: Q96L34 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MARK4 | |
BioGPS: 57787 | ||
Pathway | NCI Pathway Interaction Database: MARK4 | |
KEGG: MARK4 | ||
REACTOME: MARK4 | ||
Pathway Commons: MARK4 | ||
Context | iHOP: MARK4 | |
ligand binding site mutation search in PubMed: MARK4 | ||
UCL Cancer Institute: MARK4 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0007399 | nervous system development | 14594945 |
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Ligand binding site mutations for MARK4 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | K67 | I65F | LUAD | 1 | E185 | A184V | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MARK4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K67 | I65F | -1.0301312 | E185 | A184V | -0.2264972 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MARK4 |
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Phenotype information for MARK4 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MARK4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of MARK4 |
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LBS | AA sequence | # species | Species |
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