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mutLBSgeneDB |
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| Gene summary for PTPRG |
 Gene summary |
| Basic gene Info. | Gene symbol | PTPRG |
| Gene name | protein tyrosine phosphatase, receptor type, G | |
| Synonyms | HPTPG|PTPG|R-PTP-GAMMA|RPTPG | |
| Cytomap | UCSC genome browser: 3p21-p14 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002841.3, | |
| Description | H_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptideprotein-tyrosine phosphatase gammareceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-type protein ph | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176886 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144724 | ||
| HPRD : 01478 | ||
| Vega : OTTHUMG00000158660 | ||
| Protein | UniProt: P23470 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTPRG | |
| BioGPS: 5793 | ||
| Pathway | NCI Pathway Interaction Database: PTPRG | |
| KEGG: PTPRG | ||
| REACTOME: PTPRG | ||
| Pathway Commons: PTPRG | ||
| Context | iHOP: PTPRG | |
| ligand binding site mutation search in PubMed: PTPRG | ||
| UCL Cancer Institute: PTPRG | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0035335 | peptidyl-tyrosine dephosphorylation | 19167335 |
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| Ligand binding site mutations for PTPRG |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C1060 | H1059N | LUAD | 1 | Q1104 | V1103I | LUAD | 1 | Y841 | E839K | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PTPRG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y841 | E839K | -1.1545657 | Q1104 | V1103I | -0.71547783 | C1060 | H1059N | -0.4936152 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PTPRG from PDB |
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| Differential gene expression and gene-gene network for PTPRG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PTPRG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker, PostTranslationalModification |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PTPRG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PTPRG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | VO4 | VANADATE(3-) | 2hy3 | A | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcc | A | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcc | B | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcd | A | C1060 Q1104 | NX3 | N-[(3-AMINOPHENYL)SULFONYL]-3-[(3,4-DICHLOROBENZYL)SULFANYL]THIOPHENE-2-CARBOXAMIDE | 3qci | A | Q1104 | NX4 | 5-[({3-[(3,4-DICHLOROBENZYL)SULFANYL]THIOPHEN-2-YL}CARBONYL)SULFAMOYL]-2-METHOXYBENZOIC ACID | 3qcj | A | Q1104 | NXW | 2-[(3,4-DICHLOROBENZYL)SULFANYL]-4-{[3-({N-[2-(METHYLAMINO)ETHYL]GLYCYL}AMINO)PHENYL]ETHYNYL}BENZOICACID | 3qcm | A | Y841 | NXW | 2-[(3,4-DICHLOROBENZYL)SULFANYL]-4-{[3-({N-[2-(METHYLAMINO)ETHYL]GLYCYL}AMINO)PHENYL]ETHYNYL}BENZOICACID | 3qcm | B | Y841 |
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| Conservation information for LBS of PTPRG |
| Multiple alignments for P23470 in multiple species |
| LBS | AA sequence | # species | Species | A1062 | LVHCSAGVGRT | 2 | Homo sapiens, Mus musculus | A1062 | VVHCSAGVGRT | 1 | Gallus gallus | C1060 | PVLVHCSAGVG | 2 | Homo sapiens, Mus musculus | C1060 | PVVVHCSAGVG | 1 | Gallus gallus | D1028 | YTQWPDMGVPE | 3 | Homo sapiens, Gallus gallus, Mus musculus | E1107 | LVQTEEQYIFI | 3 | Homo sapiens, Gallus gallus, Mus musculus | F1041 | LPVLTFVRRSS | 3 | Homo sapiens, Gallus gallus, Mus musculus | F1111 | EEQYIFIHDAL | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1030 | QWPDMGVPEYA | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1063 | VHCSAGVGRTG | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1065 | CSAGVGRTGTY | 3 | Homo sapiens, Gallus gallus, Mus musculus | I1110 | TEEQYIFIHDA | 3 | Homo sapiens, Gallus gallus, Mus musculus | I950 | GIIVMITNLVE | 2 | Homo sapiens, Gallus gallus | I950 | GIIIMITNLVE | 1 | Mus musculus | P1032 | PDMGVPEYALP | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q1104 | RNYLVQTEEQY | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q1108 | VQTEEQYIFIH | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q845 | LYSNNQHGFSE | 2 | Homo sapiens, Gallus gallus | Q845 | LYSNSQHGFSE | 1 | Mus musculus | R1066 | SAGVGRTGTYI | 3 | Homo sapiens, Gallus gallus, Mus musculus | S1061 | VLVHCSAGVGR | 2 | Homo sapiens, Mus musculus | S1061 | VVVHCSAGVGR | 1 | Gallus gallus | T1069 | VGRTGTYIVID | 3 | Homo sapiens, Gallus gallus, Mus musculus | T681 | VPPTATEEQYA | 1 | Homo sapiens | T681 | VPPAFTDELYL | 1 | Gallus gallus | T681 | VPPTATEEHYS | 1 | Mus musculus | V1031 | WPDMGVPEYAL | 3 | Homo sapiens, Gallus gallus, Mus musculus | V1038 | EYALPVLTFVR | 3 | Homo sapiens, Gallus gallus, Mus musculus | V1064 | HCSAGVGRTGT | 3 | Homo sapiens, Gallus gallus, Mus musculus | W1026 | YHYTQWPDMGV | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y1023 | VIQYHYTQWPD | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y1070 | GRTGTYIVIDS | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y841 | HIGELYSNNQH | 1 | Homo sapiens | Y841 | HISELYSNNQH | 1 | Gallus gallus | Y841 | HIGELYSNSQH | 1 | Mus musculus |
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