mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PTPRG
Gene summary
Basic gene Info.Gene symbolPTPRG
Gene nameprotein tyrosine phosphatase, receptor type, G
CytomapUCSC genome browser: 3p21-p14
Type of geneprotein-coding
DescriptionH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptideprotein-tyrosine phosphatase gammareceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-type protein ph
Modification date20141207
dbXrefs MIM : 176886
Ensembl : ENSG00000144724
HPRD : 01478
Vega : OTTHUMG00000158660
ProteinUniProt: P23470
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTPRG
BioGPS: 5793
PathwayNCI Pathway Interaction Database: PTPRG
Pathway Commons: PTPRG
ContextiHOP: PTPRG
ligand binding site mutation search in PubMed: PTPRG
UCL Cancer Institute: PTPRG
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0035335peptidyl-tyrosine dephosphorylation19167335

Ligand binding site mutations for PTPRG
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PTPRG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PTPRG from PDB

Differential gene expression and gene-gene network for PTPRG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PTPRG and the right PPI network was created from samples without mutations in the LBS of PTPRG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PTPRG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038356Stomach Neoplasms1Biomarker, PostTranslationalModification

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PTPRG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PTPRG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
VO4VANADATE(3-)2hy3AC1060 Q1104
VO4VANADATE(3-)3qccAC1060 Q1104
VO4VANADATE(3-)3qccBC1060 Q1104
VO4VANADATE(3-)3qcdAC1060 Q1104

Conservation information for LBS of PTPRG
Multiple alignments for P23470 in multiple species
LBSAA sequence# speciesSpecies
A1062LVHCSAGVGRT2Homo sapiens, Mus musculus
A1062VVHCSAGVGRT1Gallus gallus
C1060PVLVHCSAGVG2Homo sapiens, Mus musculus
C1060PVVVHCSAGVG1Gallus gallus
D1028YTQWPDMGVPE3Homo sapiens, Gallus gallus, Mus musculus
E1107LVQTEEQYIFI3Homo sapiens, Gallus gallus, Mus musculus
F1041LPVLTFVRRSS3Homo sapiens, Gallus gallus, Mus musculus
F1111EEQYIFIHDAL3Homo sapiens, Gallus gallus, Mus musculus
G1030QWPDMGVPEYA3Homo sapiens, Gallus gallus, Mus musculus
G1063VHCSAGVGRTG3Homo sapiens, Gallus gallus, Mus musculus
G1065CSAGVGRTGTY3Homo sapiens, Gallus gallus, Mus musculus
I1110TEEQYIFIHDA3Homo sapiens, Gallus gallus, Mus musculus
I950GIIVMITNLVE2Homo sapiens, Gallus gallus
I950GIIIMITNLVE1Mus musculus
P1032PDMGVPEYALP3Homo sapiens, Gallus gallus, Mus musculus
Q1104RNYLVQTEEQY3Homo sapiens, Gallus gallus, Mus musculus
Q1108VQTEEQYIFIH3Homo sapiens, Gallus gallus, Mus musculus
Q845LYSNNQHGFSE2Homo sapiens, Gallus gallus
Q845LYSNSQHGFSE1Mus musculus
R1066SAGVGRTGTYI3Homo sapiens, Gallus gallus, Mus musculus
S1061VLVHCSAGVGR2Homo sapiens, Mus musculus
S1061VVVHCSAGVGR1Gallus gallus
T1069VGRTGTYIVID3Homo sapiens, Gallus gallus, Mus musculus
T681VPPTATEEQYA1Homo sapiens
T681VPPAFTDELYL1Gallus gallus
T681VPPTATEEHYS1Mus musculus
V1031WPDMGVPEYAL3Homo sapiens, Gallus gallus, Mus musculus
V1038EYALPVLTFVR3Homo sapiens, Gallus gallus, Mus musculus
V1064HCSAGVGRTGT3Homo sapiens, Gallus gallus, Mus musculus
W1026YHYTQWPDMGV3Homo sapiens, Gallus gallus, Mus musculus
Y1023VIQYHYTQWPD3Homo sapiens, Gallus gallus, Mus musculus
Y1070GRTGTYIVIDS3Homo sapiens, Gallus gallus, Mus musculus
Y841HIGELYSNNQH1Homo sapiens
Y841HISELYSNNQH1Gallus gallus
Y841HIGELYSNSQH1Mus musculus

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