mutLBSgeneDB |
Gene summary for PTPRG |
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Basic gene Info. | Gene symbol | PTPRG |
Gene name | protein tyrosine phosphatase, receptor type, G | |
Synonyms | HPTPG|PTPG|R-PTP-GAMMA|RPTPG | |
Cytomap | UCSC genome browser: 3p21-p14 | |
Type of gene | protein-coding | |
RefGenes | NM_002841.3, | |
Description | H_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptideprotein-tyrosine phosphatase gammareceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-type protein ph | |
Modification date | 20141207 | |
dbXrefs | MIM : 176886 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144724 | ||
HPRD : 01478 | ||
Vega : OTTHUMG00000158660 | ||
Protein | UniProt: P23470 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PTPRG | |
BioGPS: 5793 | ||
Pathway | NCI Pathway Interaction Database: PTPRG | |
KEGG: PTPRG | ||
REACTOME: PTPRG | ||
Pathway Commons: PTPRG | ||
Context | iHOP: PTPRG | |
ligand binding site mutation search in PubMed: PTPRG | ||
UCL Cancer Institute: PTPRG | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0035335 | peptidyl-tyrosine dephosphorylation | 19167335 |
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Ligand binding site mutations for PTPRG |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C1060 | H1059N | LUAD | 1 | Q1104 | V1103I | LUAD | 1 | Y841 | E839K | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PTPRG |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y841 | E839K | -1.1545657 | Q1104 | V1103I | -0.71547783 | C1060 | H1059N | -0.4936152 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for PTPRG |
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Phenotype information for PTPRG |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker, PostTranslationalModification |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PTPRG |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | VO4 | VANADATE(3-) | 2hy3 | A | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcc | A | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcc | B | C1060 Q1104 | VO4 | VANADATE(3-) | 3qcd | A | C1060 Q1104 | NX3 | N-[(3-AMINOPHENYL)SULFONYL]-3-[(3,4-DICHLOROBENZYL)SULFANYL]THIOPHENE-2-CARBOXAMIDE | 3qci | A | Q1104 | NX4 | 5-[({3-[(3,4-DICHLOROBENZYL)SULFANYL]THIOPHEN-2-YL}CARBONYL)SULFAMOYL]-2-METHOXYBENZOIC ACID | 3qcj | A | Q1104 | NXW | 2-[(3,4-DICHLOROBENZYL)SULFANYL]-4-{[3-({N-[2-(METHYLAMINO)ETHYL]GLYCYL}AMINO)PHENYL]ETHYNYL}BENZOICACID | 3qcm | A | Y841 | NXW | 2-[(3,4-DICHLOROBENZYL)SULFANYL]-4-{[3-({N-[2-(METHYLAMINO)ETHYL]GLYCYL}AMINO)PHENYL]ETHYNYL}BENZOICACID | 3qcm | B | Y841 |
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Conservation information for LBS of PTPRG |
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LBS | AA sequence | # species | Species | A1062 | LVHCSAGVGRT | 2 | Homo sapiens, Mus musculus | A1062 | VVHCSAGVGRT | 1 | Gallus gallus | C1060 | PVLVHCSAGVG | 2 | Homo sapiens, Mus musculus | C1060 | PVVVHCSAGVG | 1 | Gallus gallus | D1028 | YTQWPDMGVPE | 3 | Homo sapiens, Gallus gallus, Mus musculus | E1107 | LVQTEEQYIFI | 3 | Homo sapiens, Gallus gallus, Mus musculus | F1041 | LPVLTFVRRSS | 3 | Homo sapiens, Gallus gallus, Mus musculus | F1111 | EEQYIFIHDAL | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1030 | QWPDMGVPEYA | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1063 | VHCSAGVGRTG | 3 | Homo sapiens, Gallus gallus, Mus musculus | G1065 | CSAGVGRTGTY | 3 | Homo sapiens, Gallus gallus, Mus musculus | I1110 | TEEQYIFIHDA | 3 | Homo sapiens, Gallus gallus, Mus musculus | I950 | GIIVMITNLVE | 2 | Homo sapiens, Gallus gallus | I950 | GIIIMITNLVE | 1 | Mus musculus | P1032 | PDMGVPEYALP | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q1104 | RNYLVQTEEQY | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q1108 | VQTEEQYIFIH | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q845 | LYSNNQHGFSE | 2 | Homo sapiens, Gallus gallus | Q845 | LYSNSQHGFSE | 1 | Mus musculus | R1066 | SAGVGRTGTYI | 3 | Homo sapiens, Gallus gallus, Mus musculus | S1061 | VLVHCSAGVGR | 2 | Homo sapiens, Mus musculus | S1061 | VVVHCSAGVGR | 1 | Gallus gallus | T1069 | VGRTGTYIVID | 3 | Homo sapiens, Gallus gallus, Mus musculus | T681 | VPPTATEEQYA | 1 | Homo sapiens | T681 | VPPAFTDELYL | 1 | Gallus gallus | T681 | VPPTATEEHYS | 1 | Mus musculus | V1031 | WPDMGVPEYAL | 3 | Homo sapiens, Gallus gallus, Mus musculus | V1038 | EYALPVLTFVR | 3 | Homo sapiens, Gallus gallus, Mus musculus | V1064 | HCSAGVGRTGT | 3 | Homo sapiens, Gallus gallus, Mus musculus | W1026 | YHYTQWPDMGV | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y1023 | VIQYHYTQWPD | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y1070 | GRTGTYIVIDS | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y841 | HIGELYSNNQH | 1 | Homo sapiens | Y841 | HISELYSNNQH | 1 | Gallus gallus | Y841 | HIGELYSNSQH | 1 | Mus musculus |
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