mutLBSgeneDB |
Gene summary for BARD1 |
![]() |
Basic gene Info. | Gene symbol | BARD1 |
Gene name | BRCA1 associated RING domain 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q34-q35 | |
Type of gene | protein-coding | |
RefGenes | NM_000465.3, NM_001282543.1,NM_001282545.1,NM_001282548.1,NM_001282549.1, NR_104212.1,NR_104215.1,NR_104216.1, | |
Description | BRCA1-associated RING domain gene 1BRCA1-associated RING domain protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601593 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138376 | ||
HPRD : 03354 | ||
Vega : OTTHUMG00000133016 | ||
Protein | UniProt: Q99728 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BARD1 | |
BioGPS: 580 | ||
Pathway | NCI Pathway Interaction Database: BARD1 | |
KEGG: BARD1 | ||
REACTOME: BARD1 | ||
Pathway Commons: BARD1 | ||
Context | iHOP: BARD1 | |
ligand binding site mutation search in PubMed: BARD1 | ||
UCL Cancer Institute: BARD1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0046826 | negative regulation of protein export from nucleus | 15265711 | GO:0085020 | protein K6-linked ubiquitination | 12890688 |
Top |
Ligand binding site mutations for BARD1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | C71 | S72I | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for BARD1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C71 | S72I | -0.44727732 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for BARD1 |
![]() |
![]() |
Top |
Top |
Phenotype information for BARD1 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0027819 | Neuroblastoma | 10 | Biomarker, GeneticVariation |
umls:C1458155 | Breast Neoplasms | 4 | AlteredExpression, Biomarker, GeneticVariation |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for BARD1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 1jm7 | B | C71 |
Top |
Conservation information for LBS of BARD1 |
![]() |
LBS | AA sequence | # species | Species | C50 | EKLLRCSRCAN | 2 | Mus musculus, Rattus norvegicus | C50 | EKLLRCSRCTN | 1 | Homo sapiens | C53 | LRCSRCTNILR | 1 | Homo sapiens | C53 | LRCSRCANILK | 1 | Mus musculus | C53 | LRCSRCANILR | 1 | Rattus norvegicus | C66 | VCLGGCEHIFC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C71 | CEHIFCSGCIS | 2 | Mus musculus, Rattus norvegicus | C71 | CEHIFCSNCVS | 1 | Homo sapiens | C74 | IFCSGCISDCV | 2 | Mus musculus, Rattus norvegicus | C74 | IFCSNCVSDCI | 1 | Homo sapiens | C83 | CIGTGCPVCYT | 1 | Homo sapiens | C83 | CVGSGCPVCYT | 1 | Mus musculus | C83 | CVGSGCPVCHT | 1 | Rattus norvegicus | C86 | TGCPVCYTPAW | 1 | Homo sapiens | C86 | SGCPVCYTPAW | 1 | Mus musculus | C86 | SGCPVCHTPAW | 1 | Rattus norvegicus | H68 | LGGCEHIFCSG | 2 | Mus musculus, Rattus norvegicus | H68 | LGGCEHIFCSN | 1 | Homo sapiens |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |