mutLBSgeneDB |
Gene summary for CTDSP1 |
![]() |
Basic gene Info. | Gene symbol | CTDSP1 |
Gene name | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | |
Synonyms | NIF3|NLI-IF|NLIIF|SCP1 | |
Cytomap | UCSC genome browser: 2q35 | |
Type of gene | protein-coding | |
RefGenes | NM_001206878.1, NM_021198.2,NM_182642.2,NM_001206879.1, | |
Description | NLI-interacting factor 3carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1nuclear LIM interactor-interacting factor 3small C-terminal domain phosphatase 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605323 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144579 | ||
HPRD : 05615 | ||
Vega : OTTHUMG00000133109 | ||
Protein | UniProt: Q9GZU7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTDSP1 | |
BioGPS: 58190 | ||
Pathway | NCI Pathway Interaction Database: CTDSP1 | |
KEGG: CTDSP1 | ||
REACTOME: CTDSP1 | ||
Pathway Commons: CTDSP1 | ||
Context | iHOP: CTDSP1 | |
ligand binding site mutation search in PubMed: CTDSP1 | ||
UCL Cancer Institute: CTDSP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12721286 | GO:0006470 | protein dephosphorylation | 12721286 |
Top |
Ligand binding site mutations for CTDSP1 |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | L155,K157 | A156T | HNSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for CTDSP1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K157 | A156T | -0.78904895 | L155 | A156T | -0.78904895 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for CTDSP1 |
![]() |
![]() |
Top |
Top |
Phenotype information for CTDSP1 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for CTDSP1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB04156 | Aspartate Beryllium Trifluoride | Small molecule | ![]() |
Nutraceutical|vet_approved | DB04272 | Citric Acid | Small molecule | ![]() |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (SER,PRO,THR,SER,PRO) | 2ghq | A | L155 | III | Peptide ligand (SER,PRO,THR,SER,PRO) | 2ght | A | L155 | III | Peptide ligand (SER,PRO,THR,4CG) | 4yh1 | A | L155 | III | Peptide ligand (SER,PRO,THR,4CG) | 4yh1 | B | L155 | III | Peptide ligand (PRO,SER,TYR,SER,PRO,THR,SER,PRO,SER) | 2ghq | B | L155 K157 | III | Peptide ligand (SER,TYR,SER,PRO,THR,SER,PRO,SER) | 2ght | B | L155 K157 |
Top |
Conservation information for LBS of CTDSP1 |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |