|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for QDPR |
 Gene summary |
| Basic gene Info. | Gene symbol | QDPR |
| Gene name | quinoid dihydropteridine reductase | |
| Synonyms | DHPR|PKU2|SDR33C1 | |
| Cytomap | UCSC genome browser: 4p15.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000320.2, | |
| Description | 6,7-dihydropteridine reductaseHDHPRdihydropteridine reductaseshort chain dehydrogenase/reductase family 33C, member 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612676 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151552 | ||
| HPRD : 02025 | ||
| Vega : OTTHUMG00000128537 | ||
| Protein | UniProt: P09417 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_QDPR | |
| BioGPS: 5860 | ||
| Pathway | NCI Pathway Interaction Database: QDPR | |
| KEGG: QDPR | ||
| REACTOME: QDPR | ||
| Pathway Commons: QDPR | ||
| Context | iHOP: QDPR | |
| ligand binding site mutation search in PubMed: QDPR | ||
| UCL Cancer Institute: QDPR | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for QDPR |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G89 | G89E | KIRC | 1 | V86 | L84F | SKCM | 1 | N190 | P188T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for QDPR |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N190 | P188T | -1.6290809 | V86 | L84F | -0.90734092 | G89 | G89E | -0.56950923 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for QDPR from PDB |
| Top |
| Differential gene expression and gene-gene network for QDPR |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for QDPR |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0268465 | dhpr deficiency | 8 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for QDPR |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Nutraceutical | DB00157 | NADH | Small molecule |  |
| Experimental | DB03814 | 2-(N-Morpholino)-Ethanesulfonic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of QDPR go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of QDPR |
| Multiple alignments for P09417 in multiple species |
| LBS | AA sequence | # species | Species | A135 | GLLTLAGAKAA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A135 | GLLTLAGARAA | 1 | Bos taurus | A21 | YGGRGALGSRC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A87 | AILCVAGGWAG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D41 | WVASIDVVENE | 2 | Mus musculus, Rattus norvegicus | D41 | WVASVDVVENE | 1 | Homo sapiens | D41 | WVASIDVQENE | 1 | Bos taurus | G136 | LLTLAGAKAAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G136 | LLTLAGARAAL | 1 | Bos taurus | G17 | RVLVYGGRGAL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G20 | VYGGRGALGSR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G88 | ILCVAGGWAGG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G89 | LCVAGGWAGGN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K154 | GYGMAKGAVHQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K154 | GYGMAKAAVHQ | 1 | Bos taurus | L185 | VLPVTLDTPMN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L185 | LLPVTLDTPVN | 1 | Bos taurus | L22 | GGRGALGSRCV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N190 | LDTPMNRKSMP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N190 | LDTPVNRKSMP | 1 | Bos taurus | P182 | AIAVLPVTLDT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P182 | AVALLPVTLDT | 1 | Bos taurus | Q110 | DLMWKQSIWTS | 2 | Homo sapiens, Rattus norvegicus | Q110 | DLMWKQSVWTS | 1 | Bos taurus | Q110 | DMMWKQSMWTS | 1 | Mus musculus | R19 | LVYGGRGALGS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T114 | KQSIWTSTISS | 2 | Homo sapiens, Rattus norvegicus | T114 | KQSVWTSTISS | 1 | Bos taurus | T114 | KQSMWTSTISS | 1 | Mus musculus | T184 | AVLPVTLDTPM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T184 | ALLPVTLDTPV | 1 | Bos taurus | V183 | IAVLPVTLDTP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V183 | VALLPVTLDTP | 1 | Bos taurus | V40 | WWVASIDVVEN | 2 | Mus musculus, Rattus norvegicus | V40 | WWVASVDVVEN | 1 | Homo sapiens | V40 | WWVASIDVQEN | 1 | Bos taurus | V54 | SASIIVKMTDS | 1 | Homo sapiens | V54 | SANVVVKMTDS | 1 | Bos taurus | V54 | SASVVVKMTDS | 1 | Mus musculus | V54 | SASVIVKMTDS | 1 | Rattus norvegicus | V86 | DAILCVAGGWA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y150 | PGMIGYGMAKG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y150 | PGMIGYGMAKA | 1 | Bos taurus | Y16 | RRVLVYGGRGA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |