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mutLBSgeneDB |
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| Gene summary for RAB27B |
 Gene summary |
| Basic gene Info. | Gene symbol | RAB27B |
| Gene name | RAB27B, member RAS oncogene family | |
| Synonyms | C25KG | |
| Cytomap | UCSC genome browser: 18q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004163.4, | |
| Description | ras-related protein Rab-27B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603869 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000041353 | ||
| HPRD : 04846 | ||
| Vega : OTTHUMG00000132710 | ||
| Protein | UniProt: O00194 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAB27B | |
| BioGPS: 5874 | ||
| Pathway | NCI Pathway Interaction Database: RAB27B | |
| KEGG: RAB27B | ||
| REACTOME: RAB27B | ||
| Pathway Commons: RAB27B | ||
| Context | iHOP: RAB27B | |
| ligand binding site mutation search in PubMed: RAB27B | ||
| UCL Cancer Institute: RAB27B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RAB27B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A165 | A165T | COAD | 2 | D136 | D136N | SKCM | 1 | S18 | G16R | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RAB27B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D136 | D136N | -1.4498498 | A165 | A165T | -1.1629057 | S18 | G16R | -0.32179265 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAB27B from PDB |
| PDB ID | PDB title | PDB structure | 2F7S | The crystal structure of human Rab27b bound to GDP |  |
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| Differential gene expression and gene-gene network for RAB27B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RAB27B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RAB27B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RAB27B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2f7s | A | S18 D136 A165 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2f7s | B | S18 D136 A165 |
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| Conservation information for LBS of RAB27B |
| Multiple alignments for O00194 in multiple species |
| LBS | AA sequence | # species | Species | A164 | YFETSAATGQN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A165 | FETSAATGQNV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D136 | IGNKADLPDQR | 3 | Homo sapiens, Bos taurus, Mus musculus | D136 | IGNKADLLDQR | 1 | Rattus norvegicus | G19 | ALGDSGVGKTT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G21 | GDSGVGKTTFL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K134 | VLIGNKADLPD | 3 | Homo sapiens, Bos taurus, Mus musculus | K134 | VLIGNKADLLD | 1 | Rattus norvegicus | K22 | DSGVGKTTFLY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L137 | GNKADLPDQRE | 3 | Homo sapiens, Bos taurus, Mus musculus | L137 | GNKADLLDQRE | 1 | Rattus norvegicus | N133 | IVLIGNKADLP | 3 | Homo sapiens, Bos taurus, Mus musculus | N133 | IVLIGNKADLL | 1 | Rattus norvegicus | S163 | PYFETSAATGQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S18 | LALGDSGVGKT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T23 | SGVGKTTFLYR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T24 | GVGKTTFLYRY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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