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mutLBSgeneDB |
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| Gene summary for RALA |
 Gene summary |
| Basic gene Info. | Gene symbol | RALA |
| Gene name | v-ral simian leukemia viral oncogene homolog A (ras related) | |
| Synonyms | RAL | |
| Cytomap | UCSC genome browser: 7p15-p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005402.3, | |
| Description | RAS-like protein ARas family small GTP binding protein RALAras related GTP binding protein Aras-related protein Ral-A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 179550 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000006451 | ||
| HPRD : 01549 | ||
| Vega : OTTHUMG00000128775 | ||
| Protein | UniProt: P11233 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RALA | |
| BioGPS: 5898 | ||
| Pathway | NCI Pathway Interaction Database: RALA | |
| KEGG: RALA | ||
| REACTOME: RALA | ||
| Pathway Commons: RALA | ||
| Context | iHOP: RALA | |
| ligand binding site mutation search in PubMed: RALA | ||
| UCL Cancer Institute: RALA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000910 | cytokinesis | 18756269 | GO:0017157 | regulation of exocytosis | 20005108 | GO:0031532 | actin cytoskeleton reorganization | 10051605 | GO:0051491 | positive regulation of filopodium assembly | 10051605 | GO:0051665 | membrane raft localization | 20005108 |
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| Ligand binding site mutations for RALA |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G23 | G21A | COAD | 1 | D42 | D42N | SKCM | 1 | G23 | G21D | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RALA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D42 | D42N | -1.2309426 | G23 | G21D | -0.6237532 | G23 | G21A | -0.61744426 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RALA from PDB |
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| Differential gene expression and gene-gene network for RALA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RALA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RALA |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04315 | Guanosine-5'-Diphosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RALA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1zc4 | A | D42 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2a78 | A | D42 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2a9k | A | D42 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2bov | A | D42 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1zc3 | C | G23 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1uad | A | G23 D42 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1uad | B | G23 D42 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1zc3 | A | G23 D42 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1zc4 | C | G23 D42 |
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| Conservation information for LBS of RALA |
| Multiple alignments for P11233 in multiple species |
| LBS | AA sequence | # species | Species | A158 | YVETSAKTRAN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A158 | YVETSAKTREN | 1 | Drosophila melanogaster | A29 | GVGKSALTLQF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | D130 | VGNKSDLEDKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D130 | VGNKCDLNDKR | 1 | Drosophila melanogaster | D42 | DEFVEDYEPTK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | E41 | YDEFVEDYEPT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | E44 | FVEDYEPTKAD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | F39 | FMYDEFVEDYE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | G23 | IMVGSGGVGKS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | G24 | MVGSGGVGKSA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | G26 | GSGGVGKSALT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | G71 | ILDTAGQEDYA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | K128 | LLVGNKSDLED | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K128 | LLVGNKCDLND | 1 | Drosophila melanogaster | K159 | VETSAKTRANV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K159 | VETSAKTRENV | 1 | Drosophila melanogaster | K27 | SGGVGKSALTL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | L131 | GNKSDLEDKRQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L131 | GNKCDLNDKRK | 1 | Drosophila melanogaster | N127 | FLLVGNKSDLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N127 | FLLVGNKCDLN | 1 | Drosophila melanogaster | P45 | VEDYEPTKADS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | S157 | NYVETSAKTRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S157 | PYVETSAKTRE | 1 | Drosophila melanogaster | S28 | GGVGKSALTLQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | T46 | EDYEPTKADSY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | V25 | VGSGGVGKSAL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | V40 | MYDEFVEDYEP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster | Y43 | EFVEDYEPTKA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster |
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