|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for RAP2A |
 Gene summary |
| Basic gene Info. | Gene symbol | RAP2A |
| Gene name | RAP2A, member of RAS oncogene family | |
| Synonyms | K-REV|KREV|RAP2|RbBP-30 | |
| Cytomap | UCSC genome browser: 13q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021033.6, | |
| Description | RAP2, member of RAS oncogene family (K-rev)ras-related protein Rap-2a | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 179540 | |
| HGNC : HGNC | ||
| HPRD : 01547 | ||
| Protein | UniProt: P10114 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAP2A | |
| BioGPS: 5911 | ||
| Pathway | NCI Pathway Interaction Database: RAP2A | |
| KEGG: RAP2A | ||
| REACTOME: RAP2A | ||
| Pathway Commons: RAP2A | ||
| Context | iHOP: RAP2A | |
| ligand binding site mutation search in PubMed: RAP2A | ||
| UCL Cancer Institute: RAP2A | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0031532 | actin cytoskeleton reorganization | 15342639 | GO:0031954 | positive regulation of protein autophosphorylation | 15342639 | GO:0034613 | cellular protein localization | 15342639 | GO:0045184 | establishment of protein localization | 19061864 | GO:0046328 | regulation of JNK cascade | 14966141 | GO:0048814 | regulation of dendrite morphogenesis | 20159449 |
| Top |
| Ligand binding site mutations for RAP2A |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G60 | A59P | OV | 1 | P34 | P34H | STAD | 1 | G60 | G60A | THCA | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for RAP2A |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P34 | P34H | -1.1277058 | G60 | G60A | -0.62034887 | G60 | A59P | -0.59775823 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAP2A from PDB |
| Top |
| Differential gene expression and gene-gene network for RAP2A |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for RAP2A |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0003873 | Arthritis, Rheumatoid | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for RAP2A |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04137 | Guanosine-5'-Triphosphate | Small molecule |  |
| Experimental | DB04315 | Guanosine-5'-Diphosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of RAP2A go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GTP | GTP | 2rap | A | G60 | GTP | GTP | 3rap | R | P34 G60 | GTP | GTP | 3rap | S | P34 G60 |
| Top |
| Conservation information for LBS of RAP2A |
| Multiple alignments for P10114 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |