mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RARS
Gene summary
Basic gene Info.Gene symbolRARS
Gene namearginyl-tRNA synthetase
CytomapUCSC genome browser: 5q35.1
Type of geneprotein-coding
Descriptionarginine tRNA ligase 1, cytoplasmicarginine--tRNA ligase, cytoplasmicarginyl-tRNA synthetase, cytoplasmic
Modification date20141207
dbXrefs MIM : 107820
Ensembl : ENSG00000113643
HPRD : 00142
Vega : OTTHUMG00000130411
ProteinUniProt: P54136
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RARS
BioGPS: 5917
PathwayNCI Pathway Interaction Database: RARS
Pathway Commons: RARS
ContextiHOP: RARS
ligand binding site mutation search in PubMed: RARS
UCL Cancer Institute: RARS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for RARS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RARS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RARS from PDB

Differential gene expression and gene-gene network for RARS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RARS and the right PPI network was created from samples without mutations in the LBS of RARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RARS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RARS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RARS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of RARS
Multiple alignments for P54136 in multiple species
LBSAA sequence# speciesSpecies
D197KKVIVDFSSPN2Homo sapiens, Bos taurus
D197KRAVVDFSSPN2Arabidopsis thaliana, Arabidopsis thaliana
D197KRVLVDFSSPN2Caenorhabditis elegans, Drosophila melanogaster
D197EKVIVDFSSPN2Mus musculus, Rattus norvegicus
D197KKVVVDFSSPN1Xenopus tropicalis
D197KKVILDFSSPN1Gallus gallus
D388TYDTSDLAAIK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D388NYASTDLTALW2Arabidopsis thaliana, Arabidopsis thaliana
D388TYDTSDLAALK2Caenorhabditis elegans, Xenopus tropicalis
D388TYDTSDMAAIR1Drosophila melanogaster
D388TYDTSDLAALR1Gallus gallus
F416GQSVHFQTIFA1Homo sapiens
F416GQQQHFNMFFK1Arabidopsis thaliana
F416GQQQHFDMFFK1Arabidopsis thaliana
F416GQSLHLETVYA1Caenorhabditis elegans
F416GQSTHFNTIFK1Drosophila melanogaster
F416GQAIHMQNVFS1Xenopus tropicalis
F416GQSVHLQTVFA1Gallus gallus
F416GQSLHFQTVFG1Bos taurus
F416GQAIHFQTIFA1Mus musculus
F416GQATHFQTVFA1Rattus norvegicus
H211EMHVGHLRSTI8Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
H211QMHVGHLRSTI1Drosophila melanogaster
H211EMHVGHLRSTV1Xenopus tropicalis
H237VLRLNHVGDWG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H237VLRRNHVGDWG2Arabidopsis thaliana, Arabidopsis thaliana
H237VLRLNHLGDWG2Xenopus tropicalis, Gallus gallus
H237VLRVNHIGDWG1Caenorhabditis elegans
H237VIRINHLGDWG1Drosophila melanogaster
N202DFSSPNIAKEM9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N202DFSSPNIAKQM1Drosophila melanogaster
Q412VVDNGQSVHFQ1Homo sapiens
Q412VTDVGQQQHFN1Arabidopsis thaliana
Q412VTDVGQQQHFD1Arabidopsis thaliana
Q412VVDSGQSLHLE1Caenorhabditis elegans
Q412VVDSGQSTHFN1Drosophila melanogaster
Q412VIDSGQAIHMQ1Xenopus tropicalis
Q412VVDSGQSVHLQ1Gallus gallus
Q412VVDNGQSLHFQ1Bos taurus
Q412VVDNGQAIHFQ1Mus musculus
Q412VVDNGQATHFQ1Rattus norvegicus
S200IVDFSSPNIAK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S200VVDFSSPNIAK3Arabidopsis thaliana, Arabidopsis thaliana, Xenopus tropicalis
S200LVDFSSPNIAK2Caenorhabditis elegans, Drosophila melanogaster
S200ILDFSSPNIAK1Gallus gallus
V408MIIYVVDNGQS2Homo sapiens, Bos taurus
V408WIIYVTDVGQQ2Arabidopsis thaliana, Arabidopsis thaliana
V408KIIYVVDNGQA2Mus musculus, Rattus norvegicus
V408WNIYVVDSGQS1Caenorhabditis elegans
V408WIIYVVDSGQS1Drosophila melanogaster
V408MIIYVIDSGQA1Xenopus tropicalis
V408ILIYVVDSGQS1Gallus gallus
Y384DGGYTYDTSDL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y384DGGFNYASTDL2Arabidopsis thaliana, Arabidopsis thaliana
Y384DGGFTYDTSDL2Caenorhabditis elegans, Xenopus tropicalis
Y384DGGFTYDTSDM1Drosophila melanogaster
Y406ADMIIYVVDNG2Homo sapiens, Bos taurus
Y406AEWIIYVTDVG2Arabidopsis thaliana, Arabidopsis thaliana
Y406ANKIIYVVDNG2Mus musculus, Rattus norvegicus
Y406CDWNIYVVDSG1Caenorhabditis elegans
Y406CDWIIYVVDSG1Drosophila melanogaster
Y406ADMIIYVIDSG1Xenopus tropicalis
Y406GDILIYVVDSG1Gallus gallus

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