|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for RARS |
 Gene summary |
| Basic gene Info. | Gene symbol | RARS |
| Gene name | arginyl-tRNA synthetase | |
| Synonyms | ArgRS|DALRD1 | |
| Cytomap | UCSC genome browser: 5q35.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002887.3, | |
| Description | arginine tRNA ligase 1, cytoplasmicarginine--tRNA ligase, cytoplasmicarginyl-tRNA synthetase, cytoplasmic | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 107820 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113643 | ||
| HPRD : 00142 | ||
| Vega : OTTHUMG00000130411 | ||
| Protein | UniProt: P54136 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RARS | |
| BioGPS: 5917 | ||
| Pathway | NCI Pathway Interaction Database: RARS | |
| KEGG: RARS | ||
| REACTOME: RARS | ||
| Pathway Commons: RARS | ||
| Context | iHOP: RARS | |
| ligand binding site mutation search in PubMed: RARS | ||
| UCL Cancer Institute: RARS | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for RARS |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N202 | A204G | KIRC | 1 | Y384 | D385G | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for RARS |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N202 | A204G | -1.3717686 | Y384 | D385G | -0.92347964 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RARS from PDB |
| Top |
| Differential gene expression and gene-gene network for RARS |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for RARS |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for RARS |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of RARS go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of RARS |
| Multiple alignments for P54136 in multiple species |
| LBS | AA sequence | # species | Species | D197 | KKVIVDFSSPN | 2 | Homo sapiens, Bos taurus | D197 | KRAVVDFSSPN | 2 | Arabidopsis thaliana, Arabidopsis thaliana | D197 | KRVLVDFSSPN | 2 | Caenorhabditis elegans, Drosophila melanogaster | D197 | EKVIVDFSSPN | 2 | Mus musculus, Rattus norvegicus | D197 | KKVVVDFSSPN | 1 | Xenopus tropicalis | D197 | KKVILDFSSPN | 1 | Gallus gallus | D388 | TYDTSDLAAIK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D388 | NYASTDLTALW | 2 | Arabidopsis thaliana, Arabidopsis thaliana | D388 | TYDTSDLAALK | 2 | Caenorhabditis elegans, Xenopus tropicalis | D388 | TYDTSDMAAIR | 1 | Drosophila melanogaster | D388 | TYDTSDLAALR | 1 | Gallus gallus | F416 | GQSVHFQTIFA | 1 | Homo sapiens | F416 | GQQQHFNMFFK | 1 | Arabidopsis thaliana | F416 | GQQQHFDMFFK | 1 | Arabidopsis thaliana | F416 | GQSLHLETVYA | 1 | Caenorhabditis elegans | F416 | GQSTHFNTIFK | 1 | Drosophila melanogaster | F416 | GQAIHMQNVFS | 1 | Xenopus tropicalis | F416 | GQSVHLQTVFA | 1 | Gallus gallus | F416 | GQSLHFQTVFG | 1 | Bos taurus | F416 | GQAIHFQTIFA | 1 | Mus musculus | F416 | GQATHFQTVFA | 1 | Rattus norvegicus | H211 | EMHVGHLRSTI | 8 | Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | H211 | QMHVGHLRSTI | 1 | Drosophila melanogaster | H211 | EMHVGHLRSTV | 1 | Xenopus tropicalis | H237 | VLRLNHVGDWG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H237 | VLRRNHVGDWG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | H237 | VLRLNHLGDWG | 2 | Xenopus tropicalis, Gallus gallus | H237 | VLRVNHIGDWG | 1 | Caenorhabditis elegans | H237 | VIRINHLGDWG | 1 | Drosophila melanogaster | N202 | DFSSPNIAKEM | 9 | Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Xenopus tropicalis, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | N202 | DFSSPNIAKQM | 1 | Drosophila melanogaster | Q412 | VVDNGQSVHFQ | 1 | Homo sapiens | Q412 | VTDVGQQQHFN | 1 | Arabidopsis thaliana | Q412 | VTDVGQQQHFD | 1 | Arabidopsis thaliana | Q412 | VVDSGQSLHLE | 1 | Caenorhabditis elegans | Q412 | VVDSGQSTHFN | 1 | Drosophila melanogaster | Q412 | VIDSGQAIHMQ | 1 | Xenopus tropicalis | Q412 | VVDSGQSVHLQ | 1 | Gallus gallus | Q412 | VVDNGQSLHFQ | 1 | Bos taurus | Q412 | VVDNGQAIHFQ | 1 | Mus musculus | Q412 | VVDNGQATHFQ | 1 | Rattus norvegicus | S200 | IVDFSSPNIAK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S200 | VVDFSSPNIAK | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Xenopus tropicalis | S200 | LVDFSSPNIAK | 2 | Caenorhabditis elegans, Drosophila melanogaster | S200 | ILDFSSPNIAK | 1 | Gallus gallus | V408 | MIIYVVDNGQS | 2 | Homo sapiens, Bos taurus | V408 | WIIYVTDVGQQ | 2 | Arabidopsis thaliana, Arabidopsis thaliana | V408 | KIIYVVDNGQA | 2 | Mus musculus, Rattus norvegicus | V408 | WNIYVVDSGQS | 1 | Caenorhabditis elegans | V408 | WIIYVVDSGQS | 1 | Drosophila melanogaster | V408 | MIIYVIDSGQA | 1 | Xenopus tropicalis | V408 | ILIYVVDSGQS | 1 | Gallus gallus | Y384 | DGGYTYDTSDL | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y384 | DGGFNYASTDL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | Y384 | DGGFTYDTSDL | 2 | Caenorhabditis elegans, Xenopus tropicalis | Y384 | DGGFTYDTSDM | 1 | Drosophila melanogaster | Y406 | ADMIIYVVDNG | 2 | Homo sapiens, Bos taurus | Y406 | AEWIIYVTDVG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | Y406 | ANKIIYVVDNG | 2 | Mus musculus, Rattus norvegicus | Y406 | CDWNIYVVDSG | 1 | Caenorhabditis elegans | Y406 | CDWIIYVVDSG | 1 | Drosophila melanogaster | Y406 | ADMIIYVIDSG | 1 | Xenopus tropicalis | Y406 | GDILIYVVDSG | 1 | Gallus gallus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |