mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RBBP7
Gene summary
Basic gene Info.Gene symbolRBBP7
Gene nameretinoblastoma binding protein 7
SynonymsRbAp46
CytomapUCSC genome browser: Xp22.2
Type of geneprotein-coding
RefGenesNM_001198719.1,
NM_002893.3,
DescriptionG1/S transition control protein-binding protein RbAp46RBBP-7histone acetyltransferase type B subunit 2histone-binding protein RBBP7nucleosome-remodeling factor subunit RBAP46retinoblastoma-binding protein 7retinoblastoma-binding protein RbAp46retin
Modification date20141207
dbXrefs MIM : 300825
HGNC : HGNC
Ensembl : ENSG00000102054
HPRD : 04231
Vega : OTTHUMG00000021198
ProteinUniProt: Q16576
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RBBP7
BioGPS: 5931
PathwayNCI Pathway Interaction Database: RBBP7
KEGG: RBBP7
REACTOME: RBBP7
Pathway Commons: RBBP7
ContextiHOP: RBBP7
ligand binding site mutation search in PubMed: RBBP7
UCL Cancer Institute: RBBP7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0030308negative regulation of cell growth9765217
GO:0070370cellular heat acclimation7503932


Top
Ligand binding site mutations for RBBP7
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
I368H369LBLCA1
N17V15ICOAD1
F29P28LUCEC1
D9D9YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for RBBP7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N17V15I-0.59246825
D9D9Y-0.37825396
F29P28L-0.18955764
I368H369L-0.10026499
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RBBP7 from PDB

Top
Differential gene expression and gene-gene network for RBBP7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RBBP7 and the right PPI network was created from samples without mutations in the LBS of RBBP7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for RBBP7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for RBBP7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RBBP7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLN,GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY)3cfsBF29 I368
IIIPeptide ligand (ASP,ASN,ILE,GLN,GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY)3cfvBF29 I368
IIIPeptide ligand (GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY)3cfvAF29 I368


Top
Conservation information for LBS of RBBP7
Multiple alignments for Q16576 in multiple species
LBSAA sequence# speciesSpecies
D357EQSAEDAEDGP7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
D360AEDAEDGPPEL7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
D9KEMFEDTVEER5Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Xenopus tropicalis
D9KEVYDDAVEER1Danio rerio
D9KEVLEDTVEER1Gallus gallus
E356EEQSAEDAEDG7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
F29KKNTPFLYDLV7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
F367PPELLFIHGGH7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
G361EDAEDGPPELL7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
I368PELLFIHGGHT7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
I407QMAENIYNDEE7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
L30KNTPFLYDLVM7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
L365DGPPELLFIHG7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
L366GPPELLFIHGG7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
N17EERVINEEYKI6Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Xenopus tropicalis
N17EERVISEEYKI1Gallus gallus
N26KIWKKNTPFLY7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
N406WQMAENIYNDE7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
P362DAEDGPPELLF7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
P363AEDGPPELLFI7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
Q353KIGEEQSAEDA7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis
W23EEYKIWKKNTP7Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas