mutLBSgeneDB |
Gene summary for RBBP7 |
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Basic gene Info. | Gene symbol | RBBP7 |
Gene name | retinoblastoma binding protein 7 | |
Synonyms | RbAp46 | |
Cytomap | UCSC genome browser: Xp22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001198719.1, NM_002893.3, | |
Description | G1/S transition control protein-binding protein RbAp46RBBP-7histone acetyltransferase type B subunit 2histone-binding protein RBBP7nucleosome-remodeling factor subunit RBAP46retinoblastoma-binding protein 7retinoblastoma-binding protein RbAp46retin | |
Modification date | 20141207 | |
dbXrefs | MIM : 300825 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102054 | ||
HPRD : 04231 | ||
Vega : OTTHUMG00000021198 | ||
Protein | UniProt: Q16576 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RBBP7 | |
BioGPS: 5931 | ||
Pathway | NCI Pathway Interaction Database: RBBP7 | |
KEGG: RBBP7 | ||
REACTOME: RBBP7 | ||
Pathway Commons: RBBP7 | ||
Context | iHOP: RBBP7 | |
ligand binding site mutation search in PubMed: RBBP7 | ||
UCL Cancer Institute: RBBP7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0030308 | negative regulation of cell growth | 9765217 | GO:0070370 | cellular heat acclimation | 7503932 |
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Ligand binding site mutations for RBBP7 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | I368 | H369L | BLCA | 1 | N17 | V15I | COAD | 1 | F29 | P28L | UCEC | 1 | D9 | D9Y | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RBBP7 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N17 | V15I | -0.59246825 | D9 | D9Y | -0.37825396 | F29 | P28L | -0.18955764 | I368 | H369L | -0.10026499 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for RBBP7 |
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Phenotype information for RBBP7 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RBBP7 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLN,GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY) | 3cfs | B | F29 I368 | III | Peptide ligand (ASP,ASN,ILE,GLN,GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY) | 3cfv | B | F29 I368 | III | Peptide ligand (GLY,ILE,THR,LYS,PRO,ALA,ILE,ARG,ARG,LEU,ALA,ARG,ARG,GLY) | 3cfv | A | F29 I368 |
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Conservation information for LBS of RBBP7 |
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LBS | AA sequence | # species | Species | D357 | EQSAEDAEDGP | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | D360 | AEDAEDGPPEL | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | D9 | KEMFEDTVEER | 5 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Xenopus tropicalis | D9 | KEVYDDAVEER | 1 | Danio rerio | D9 | KEVLEDTVEER | 1 | Gallus gallus | E356 | EEQSAEDAEDG | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | F29 | KKNTPFLYDLV | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | F367 | PPELLFIHGGH | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | G361 | EDAEDGPPELL | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | I368 | PELLFIHGGHT | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | I407 | QMAENIYNDEE | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | L30 | KNTPFLYDLVM | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | L365 | DGPPELLFIHG | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | L366 | GPPELLFIHGG | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | N17 | EERVINEEYKI | 6 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Xenopus tropicalis | N17 | EERVISEEYKI | 1 | Gallus gallus | N26 | KIWKKNTPFLY | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | N406 | WQMAENIYNDE | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | P362 | DAEDGPPELLF | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | P363 | AEDGPPELLFI | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | Q353 | KIGEEQSAEDA | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis | W23 | EEYKIWKKNTP | 7 | Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus, Mus musculus, Gallus gallus, Xenopus tropicalis |
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