mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for REN
Gene summary
Basic gene Info.Gene symbolREN
Gene namerenin
SynonymsHNFJ2
CytomapUCSC genome browser: 1q32
Type of geneprotein-coding
RefGenesNM_000537.3,
Descriptionangiotensin-forming enzymeangiotensinogenaserenin precursor, renal
Modification date20141219
dbXrefs MIM : 179820
HGNC : HGNC
Ensembl : ENSG00000143839
HPRD : 01564
Vega : OTTHUMG00000036059
ProteinUniProt: P00797
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_REN
BioGPS: 5972
PathwayNCI Pathway Interaction Database: REN
KEGG: REN
REACTOME: REN
Pathway Commons: REN
ContextiHOP: REN
ligand binding site mutation search in PubMed: REN
UCL Cancer Institute: REN
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0002003angiotensin maturation12045255
GO:0006508proteolysis12045255
GO:0043408regulation of MAPK cascade12045255


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Ligand binding site mutations for REN

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R148R148HBRCA1
T375P377HCOAD1
R317K315NCOAD1
E189E189DCOAD1
V102V102IGBM1
R148R148CGBM1
Q201Q201LKIRC1
L244G245ELUAD1
T151T151AOV1
N141,T143G142RSKCM1
N141,T143G142ESKCM1
H127L129HSKCM1
H367,T363A365DSKCM1
I168I168VSTAD1
G294G294SSTAD1
L183A182VUCEC1
T375G376RUCEC1
S107S107LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for REN
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R148R148H-1.6336804
R148R148C-1.3205688
H127L129H-1.2965171
E189E189D-1.0973842
T375P377H-1.0011554
I168I168V-0.91524091
T375G376R-0.85528568
V102V102I-0.79068354
H367A365D-0.78792125
T363A365D-0.78792125
T151T151A-0.66903751
G294G294S-0.61938966
R317K315N-0.60660369
L183A182V-0.47324591
S107S107L-0.44436511
Q201Q201L-0.23882474
T143G142R-0.13492217
N141G142R-0.13492217
N141G142E-0.085065278
T143G142E-0.085065278
L244G245E-0.025960781
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for REN from PDB

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Differential gene expression and gene-gene network for REN
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of REN and the right PPI network was created from samples without mutations in the LBS of REN. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for REN
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension380Biomarker, GeneticVariation
umls:C0022658Kidney Diseases50Biomarker, GeneticVariation
umls:C0018801Heart Failure35Biomarker, GeneticVariation
umls:C0027051Myocardial Infarction28AlteredExpression, Biomarker, GeneticVariation
umls:C0149721Hypertrophy, Left Ventricular27Biomarker
umls:C0020540Hypertension, Malignant8Biomarker
umls:C0266313Allanson Pantzar McLeod syndrome7Biomarker, GeneticVariation
umls:C0002871Anemia6Biomarker
umls:C0004775Bartter Syndrome6Biomarker
umls:C0221043Liddle Syndrome5Biomarker
umls:C0022116Ischemia3Biomarker
umls:C0020649Hypotension3Biomarker, Therapeutic
umls:C0033860Psoriasis2Biomarker
umls:C0001925Albuminuria2Biomarker
umls:C0018800Cardiomegaly2Biomarker
umls:C0027720Nephrosis2Biomarker
umls:C0033687Proteinuria2Biomarker
umls:C2751310Hyperuricemic Nephropathy, Familial Juvenile 21Biomarker, GeneticVariation
umls:C0029456Osteoporosis1Biomarker
umls:C0242528Azotemia1Biomarker
umls:C0011853Diabetes Mellitus, Experimental1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0015934Fetal Growth Retardation1Biomarker
umls:C0016059Fibrosis1Biomarker
umls:C0019080Hemorrhage1Biomarker
umls:C0023890Liver Cirrhosis1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for REN
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00212RemikirenSmall molecule
ExperimentalDB01844DimethylformamideSmall molecule
ExperimentalDB022961-Hydroxy-3-MethylbutaneSmall molecule
ExperimentalDB028033-Phenyl-1,2-PropandiolSmall molecule
ExperimentalDB030242-Methyl-3-(2-Aminothiazolo)PropanalSmall molecule
ExperimentalDB03395EnalkirenSmall molecule
ExperimentalDB037362-CyclopropylmethylenepropanalSmall molecule
ExperimentalDB039681-Methyl-2-Oxy-5,5-Dimethyl PyrrolidineSmall molecule
ExperimentalDB04379N-Methyl-N-(Methylbenzyl)FormamideSmall molecule
ExperimentalDB043871-Hydroxy-2-Amino-3-CyclohexylpropaneSmall molecule
InvestigationalDB05203SPP1148Small molecule
ExperimentalDB06899N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDESmall molecule
ExperimentalDB069676-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINESmall molecule
ExperimentalDB07059N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDESmall molecule
ExperimentalDB07113(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONESmall molecule
ExperimentalDB071746-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONESmall molecule
ExperimentalDB072445-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINESmall molecule
ExperimentalDB080996-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamineSmall molecule
Approved|investigationalDB09026AliskirenSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of REN go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
70Y(2Z,6S)-2-IMINO-6-METHYL-3-{3-[(4R)-2-OXO-4- PHENYLPYRROLIDIN-1-YL]BENZYL}-6-(PROPAN-2-YL) TETRAHYDROPYRIMIDIN-4(1H)-ONE4xx4AT151 G294
70Y(2Z,6S)-2-IMINO-6-METHYL-3-{3-[(4R)-2-OXO-4- PHENYLPYRROLIDIN-1-YL]BENZYL}-6-(PROPAN-2-YL) TETRAHYDROPYRIMIDIN-4(1H)-ONE4xx4BT151 G294
43T3-{[(4S)-2-AMINO-4-METHYL-6-OXO-4-(PROPAN-2-YL)-5,6- DIHYDROPYRIMIDIN-1(4H)-YL]METHYL}-5-FLUORO-N-[(1S)-1- PHENYLETHYL]BENZAMIDE4s1gAT151 G294 H367
43T3-{[(4S)-2-AMINO-4-METHYL-6-OXO-4-(PROPAN-2-YL)-5,6- DIHYDROPYRIMIDIN-1(4H)-YL]METHYL}-5-FLUORO-N-[(1S)-1- PHENYLETHYL]BENZAMIDE4s1gBT151 G294 H367
70XN-BENZYL-3-{[(2Z,4S)-2-IMINO-4-METHYL-6-OXO-4-(PROPAN- 2-YL)TETRAHYDROPYRIMIDIN-1(2H)-YL]METHYL}BENZAMIDE4xx3AV102 T151 G294
70XN-BENZYL-3-{[(2Z,4S)-2-IMINO-4-METHYL-6-OXO-4-(PROPAN- 2-YL)TETRAHYDROPYRIMIDIN-1(2H)-YL]METHYL}BENZAMIDE4xx3BV102 T151 G294


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Conservation information for LBS of REN
Multiple alignments for P00797 in multiple species
LBSAA sequence# speciesSpecies
A188LPFMLAEFDGV3Homo sapiens, Pan troglodytes, Macaca mulatta
A188IPFMLAKFDGV3Canis lupus familiaris, Mus musculus, Rattus norvegicus
A295LVDTGASYISG3Homo sapiens, Pan troglodytes, Macaca mulatta
A295VVDTGASYISG1Canis lupus familiaris
A295VVDTGSSFISA1Mus musculus
A295VVDTGTSYISG1Rattus norvegicus
A368TLAIHAMDIPP3Homo sapiens, Pan troglodytes, Macaca mulatta
A368TLALHGLDVPP1Canis lupus familiaris
A368TLALHAMDIPP1Mus musculus
A368ILALQGLDIPP1Rattus norvegicus
A380TGPTWALGATF3Homo sapiens, Pan troglodytes, Macaca mulatta
A380TGPVWVLGATF2Mus musculus, Rattus norvegicus
A380TGPVWVLGASF1Canis lupus familiaris
A383TWALGATFIRK3Homo sapiens, Pan troglodytes, Macaca mulatta
A383VWVLGATFIRK2Mus musculus, Rattus norvegicus
A383VWVLGASFIRK1Canis lupus familiaris
D104FKVVFDTGSSN3Homo sapiens, Pan troglodytes, Macaca mulatta
D104FKVIFDTGSAN2Mus musculus, Rattus norvegicus
D104FKVVFDTGSAN1Canis lupus familiaris
D191MLAEFDGVVGM3Homo sapiens, Pan troglodytes, Macaca mulatta
D191MLAKFDGVLGM3Canis lupus familiaris, Mus musculus, Rattus norvegicus
D248VLGGSDPQHYE3Homo sapiens, Pan troglodytes, Macaca mulatta
D248VLGGSDPQHYQ2Mus musculus, Rattus norvegicus
D248VLGGSDPQYYQ1Canis lupus familiaris
D292CLALVDTGASY3Homo sapiens, Pan troglodytes, Macaca mulatta
D292CMVVVDTGASY1Canis lupus familiaris
D292CAVVVDTGSSF1Mus musculus
D292CMAVVDTGTSY1Rattus norvegicus
D320-KRLFDYVVKC3Homo sapiens, Pan troglodytes, Macaca mulatta
D320ELSTNEYVVNC1Canis lupus familiaris
D320EKRIEEYVVNC1Mus musculus
D320EKRANNYVVNC1Rattus norvegicus
D83LTNYMDTQYYG3Homo sapiens, Pan troglodytes, Macaca mulatta
D83LTNYLDTQYYG2Canis lupus familiaris, Rattus norvegicus
D83LTNYLNTQYYG1Mus musculus
E189PFMLAEFDGVV3Homo sapiens, Pan troglodytes, Macaca mulatta
E189PFMLAKFDGVL3Canis lupus familiaris, Mus musculus, Rattus norvegicus
E89TQYYGEIGIGT6Homo sapiens, Pan troglodytes, Macaca mulatta, Canis lupus familiaris, Mus musculus, Rattus norvegicus
F103TFKVVFDTGSS3Homo sapiens, Pan troglodytes, Macaca mulatta
F103TFKVIFDTGSA2Mus musculus, Rattus norvegicus
F103TFKVVFDTGSA1Canis lupus familiaris
F185MPALPFMLAEF3Homo sapiens, Pan troglodytes, Macaca mulatta
F185LPLIPFMLAKF3Canis lupus familiaris, Mus musculus, Rattus norvegicus
F190FMLAEFDGVVG3Homo sapiens, Pan troglodytes, Macaca mulatta
F190FMLAKFDGVLG3Canis lupus familiaris, Mus musculus, Rattus norvegicus
F319K-KRLFDYVVK3Homo sapiens, Pan troglodytes, Macaca mulatta
F319QELSTNEYVVN1Canis lupus familiaris
F319KEKRIEEYVVN1Mus musculus
F319KEKRANNYVVN1Rattus norvegicus
F352SADYVFQESYS3Homo sapiens, Pan troglodytes, Macaca mulatta
F352SKDYVLQDPYG1Canis lupus familiaris
F352STDYVLQYPNR1Mus musculus
F352NMDYVQKNPFR1Rattus norvegicus
G106VVFDTGSSNVW3Homo sapiens, Pan troglodytes, Macaca mulatta
G106VIFDTGSANLW2Mus musculus, Rattus norvegicus
G106VVFDTGSANLW1Canis lupus familiaris
G152LRYSTGTVSGF3Homo sapiens, Pan troglodytes, Macaca mulatta
G152IRYGSGKVKGF1Canis lupus familiaris
G152IHYGSGRVKGF1Mus musculus
G152IHYGSGKVKGF1Rattus norvegicus
G166DIITVGGITVT3Homo sapiens, Pan troglodytes, Macaca mulatta
G166DMVTVGGITVT1Canis lupus familiaris
G166DSVTVGGITVT1Mus musculus
G166DVVTVGGIIVT1Rattus norvegicus
G192LAEFDGVVGMG3Homo sapiens, Pan troglodytes, Macaca mulatta
G192LAKFDGVLGMG3Canis lupus familiaris, Mus musculus, Rattus norvegicus
G240SHLLGGEVVLG3Canis lupus familiaris, Mus musculus, Rattus norvegicus
G240SQSLGGQIVLG2Homo sapiens, Pan troglodytes
G240AQSLGGQIVLG1Macaca mulatta
G294ALVDTGASYIS3Homo sapiens, Pan troglodytes, Macaca mulatta
G294VVVDTGASYIS1Canis lupus familiaris
G294VVVDTGSSFIS1Mus musculus
G294AVVDTGTSYIS1Rattus norvegicus
H127TACVYHKLFDA3Homo sapiens, Pan troglodytes, Macaca mulatta
H127TACEIHCLYDS1Canis lupus familiaris
H127LACGIHSLYES1Mus musculus
H127TACEIHNLYDS1Rattus norvegicus
H367CTLAIHAMDIP3Homo sapiens, Pan troglodytes, Macaca mulatta
H367CTLALHGLDVP1Canis lupus familiaris
H367CTLALHAMDIP1Mus musculus
H367CILALQGLDIP1Rattus norvegicus
I168ITVGGITVTQM3Homo sapiens, Pan troglodytes, Macaca mulatta
I168VTVGGITVTQT2Canis lupus familiaris, Mus musculus
I168VTVGGIIVTQT1Rattus norvegicus
I203FIEQAIGRVTP3Homo sapiens, Pan troglodytes, Macaca mulatta
I203FPAQAVGGVTP2Canis lupus familiaris, Mus musculus
I203FPAQAVDGVIP1Rattus norvegicus
I242SLGGQIVLGGS3Homo sapiens, Pan troglodytes, Macaca mulatta
I242LLGGEVVLGGS3Canis lupus familiaris, Mus musculus, Rattus norvegicus
I371IHAMDIPPPTG3Homo sapiens, Pan troglodytes, Macaca mulatta
I371LHGLDVPPPTG1Canis lupus familiaris
I371LHAMDIPPPTG1Mus musculus
I371LQGLDIPPPTG1Rattus norvegicus
L147GTELTLRYSTG3Homo sapiens, Pan troglodytes, Macaca mulatta
L147GTTFTIRYGSG1Canis lupus familiaris
L147GSDFTIHYGSG1Mus musculus
L147GTEFTIHYGSG1Rattus norvegicus
L158TVSGFLSQDII3Homo sapiens, Pan troglodytes, Macaca mulatta
L158KVKGFLSQDMV1Canis lupus familiaris
L158RVKGFLSQDSV1Mus musculus
L158KVKGFLSQDVV1Rattus norvegicus
L183TEMPALPFMLA3Homo sapiens, Pan troglodytes, Macaca mulatta
L183TELPLIPFMLA3Canis lupus familiaris, Mus musculus, Rattus norvegicus
L187ALPFMLAEFDG3Homo sapiens, Pan troglodytes, Macaca mulatta
L187LIPFMLAKFDG3Canis lupus familiaris, Mus musculus, Rattus norvegicus
L244GGQIVLGGSDP3Homo sapiens, Pan troglodytes, Macaca mulatta
L244GGEVVLGGSDP3Canis lupus familiaris, Mus musculus, Rattus norvegicus
L290DGCLALVDTGA3Homo sapiens, Pan troglodytes, Macaca mulatta
L290EGCMVVVDTGA1Canis lupus familiaris
L290EGCAVVVDTGS1Mus musculus
L290EGCMAVVDTGT1Rattus norvegicus
L318AK-KRLFDYVV3Homo sapiens, Pan troglodytes, Macaca mulatta
L318AQELSTNEYVV1Canis lupus familiaris
L318AKEKRIEEYVV1Mus musculus
L318VKEKRANNYVV1Rattus norvegicus
M180GEVTEMPALPF3Homo sapiens, Pan troglodytes, Macaca mulatta
M180GEVTELPLIPF3Canis lupus familiaris, Mus musculus, Rattus norvegicus
M369LAIHAMDIPPP3Homo sapiens, Pan troglodytes, Macaca mulatta
M369LALHGLDVPPP1Canis lupus familiaris
M369LALHAMDIPPP1Mus musculus
M369LALQGLDIPPP1Rattus norvegicus
M82ILTNYMDTQYY3Homo sapiens, Pan troglodytes, Macaca mulatta
M82VLTNYLDTQYY2Canis lupus familiaris, Rattus norvegicus
M82VLTNYLNTQYY1Mus musculus
N109DTGSSNVWVPS3Homo sapiens, Pan troglodytes, Macaca mulatta
N109DTGSANLWVPS3Canis lupus familiaris, Mus musculus, Rattus norvegicus
N141SSYKHNGTELT3Homo sapiens, Pan troglodytes, Macaca mulatta
N141SSYMENGTTFT1Canis lupus familiaris
N141SSYMENGSDFT1Mus musculus
N141SSYMENGTEFT1Rattus norvegicus
P113SNVWVPSSKCS3Homo sapiens, Pan troglodytes, Macaca mulatta
P113ANLWVPSTRCS1Canis lupus familiaris
P113ANLWVPSTKCS1Mus musculus
P113ANLWVPSTKCG1Rattus norvegicus
P184EMPALPFMLAE3Homo sapiens, Pan troglodytes, Macaca mulatta
P184ELPLIPFMLAK3Canis lupus familiaris, Mus musculus, Rattus norvegicus
P372HAMDIPPPTGP4Homo sapiens, Pan troglodytes, Macaca mulatta, Mus musculus
P372HGLDVPPPTGP1Canis lupus familiaris
P372QGLDIPPPTGP1Rattus norvegicus
Q201MGFIEQAIGRV3Homo sapiens, Pan troglodytes, Macaca mulatta
Q201MGFPAQAVGGV2Canis lupus familiaris, Mus musculus
Q201MGFPAQAVDGV1Rattus norvegicus
Q241QSLGGQIVLGG3Homo sapiens, Pan troglodytes, Macaca mulatta
Q241HLLGGEVVLGG3Canis lupus familiaris, Mus musculus, Rattus norvegicus
Q85NYMDTQYYGEI3Homo sapiens, Pan troglodytes, Macaca mulatta
Q85NYLDTQYYGEI2Canis lupus familiaris, Rattus norvegicus
Q85NYLNTQYYGEI1Mus musculus
R148TELTLRYSTGT3Homo sapiens, Pan troglodytes, Macaca mulatta
R148TTFTIRYGSGK1Canis lupus familiaris
R148SDFTIHYGSGR1Mus musculus
R148TEFTIHYGSGK1Rattus norvegicus
R317GAK-KRLFDYV3Homo sapiens, Pan troglodytes, Macaca mulatta
R317GAQELSTNEYV1Canis lupus familiaris
R317GAKEKRIEEYV1Mus musculus
R317GVKEKRANNYV1Rattus norvegicus
S107VFDTGSSNVWV3Homo sapiens, Pan troglodytes, Macaca mulatta
S107IFDTGSANLWV2Mus musculus, Rattus norvegicus
S107VFDTGSANLWV1Canis lupus familiaris
S108FDTGSSNVWVP3Homo sapiens, Pan troglodytes, Macaca mulatta
S108FDTGSANLWVP3Canis lupus familiaris, Mus musculus, Rattus norvegicus
S150LTLRYSTGTVS3Homo sapiens, Pan troglodytes, Macaca mulatta
S150FTIRYGSGKVK1Canis lupus familiaris
S150FTIHYGSGRVK1Mus musculus
S150FTIHYGSGKVK1Rattus norvegicus
S296VDTGASYISGS3Homo sapiens, Pan troglodytes, Macaca mulatta
S296VDTGASYISGP1Canis lupus familiaris
S296VDTGSSFISAP1Mus musculus
S296VDTGTSYISGP1Rattus norvegicus
S299GASYISGSTSS3Homo sapiens, Pan troglodytes, Macaca mulatta
S299GASYISGPTSS1Canis lupus familiaris
S299GSSFISAPTSS1Mus musculus
S299GTSYISGPTSS1Rattus norvegicus
T143YKHNGTELTLR3Homo sapiens, Pan troglodytes, Macaca mulatta
T143YMENGTTFTIR1Canis lupus familiaris
T143YMENGSDFTIH1Mus musculus
T143YMENGTEFTIH1Rattus norvegicus
T151TLRYSTGTVSG3Homo sapiens, Pan troglodytes, Macaca mulatta
T151TIRYGSGKVKG1Canis lupus familiaris
T151TIHYGSGRVKG1Mus musculus
T151TIHYGSGKVKG1Rattus norvegicus
T293LALVDTGASYI3Homo sapiens, Pan troglodytes, Macaca mulatta
T293MVVVDTGASYI1Canis lupus familiaris
T293AVVVDTGSSFI1Mus musculus
T293MAVVDTGTSYI1Rattus norvegicus
T363SKKLCTLAIHA3Homo sapiens, Pan troglodytes, Macaca mulatta
T363NEDLCTLALHG1Canis lupus familiaris
T363RDKLCTLALHA1Mus musculus
T363NDDLCILALQG1Rattus norvegicus
T375DIPPPTGPTWA3Homo sapiens, Pan troglodytes, Macaca mulatta
T375DIPPPTGPVWV2Mus musculus, Rattus norvegicus
T375DVPPPTGPVWV1Canis lupus familiaris
T84TNYMDTQYYGE3Homo sapiens, Pan troglodytes, Macaca mulatta
T84TNYLDTQYYGE2Canis lupus familiaris, Rattus norvegicus
T84TNYLNTQYYGE1Mus musculus
V102QTFKVVFDTGS4Homo sapiens, Pan troglodytes, Macaca mulatta, Canis lupus familiaris
V102QTFKVIFDTGS2Mus musculus, Rattus norvegicus
V112SSNVWVPSSKC3Homo sapiens, Pan troglodytes, Macaca mulatta
V112SANLWVPSTKC2Mus musculus, Rattus norvegicus
V112SANLWVPSTRC1Canis lupus familiaris
V154YSTGTVSGFLS3Homo sapiens, Pan troglodytes, Macaca mulatta
V154YGSGKVKGFLS2Canis lupus familiaris, Rattus norvegicus
V154YGSGRVKGFLS1Mus musculus
V177QMFGEVTEMPA3Homo sapiens, Pan troglodytes, Macaca mulatta
V177QTFGEVTELPL3Canis lupus familiaris, Mus musculus, Rattus norvegicus
V193AEFDGVVGMGF3Homo sapiens, Pan troglodytes, Macaca mulatta
V193AKFDGVLGMGF3Canis lupus familiaris, Mus musculus, Rattus norvegicus
V243LGGQIVLGGSD3Homo sapiens, Pan troglodytes, Macaca mulatta
V243LGGEVVLGGSD3Canis lupus familiaris, Mus musculus, Rattus norvegicus
W111GSSNVWVPSSK3Homo sapiens, Pan troglodytes, Macaca mulatta
W111GSANLWVPSTK2Mus musculus, Rattus norvegicus
W111GSANLWVPSTR1Canis lupus familiaris
Y149ELTLRYSTGTV3Homo sapiens, Pan troglodytes, Macaca mulatta
Y149TFTIRYGSGKV1Canis lupus familiaris
Y149DFTIHYGSGRV1Mus musculus
Y149EFTIHYGSGKV1Rattus norvegicus
Y228VFSFYYNRDSE3Homo sapiens, Pan troglodytes, Macaca mulatta
Y228VFSVYYSR---2Canis lupus familiaris, Rattus norvegicus
Y228VFSVYYNR---1Mus musculus
Y297DTGASYISGST3Homo sapiens, Pan troglodytes, Macaca mulatta
Y297DTGASYISGPT1Canis lupus familiaris
Y297DTGSSFISAPT1Mus musculus
Y297DTGTSYISGPT1Rattus norvegicus
Y86YMDTQYYGEIG3Homo sapiens, Pan troglodytes, Macaca mulatta
Y86YLDTQYYGEIG2Canis lupus familiaris, Rattus norvegicus
Y86YLNTQYYGEIG1Mus musculus
Y87MDTQYYGEIGI3Homo sapiens, Pan troglodytes, Macaca mulatta
Y87LDTQYYGEIGI2Canis lupus familiaris, Rattus norvegicus
Y87LNTQYYGEIGI1Mus musculus


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