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mutLBSgeneDB |
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| Gene summary for RNASE2 |
 Gene summary |
| Basic gene Info. | Gene symbol | RNASE2 |
| Gene name | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | |
| Synonyms | EDN|RAF3|RNS2 | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002934.2, | |
| Description | RNase 2RNase UpI-2eosinophil-derived neurotoxinnon-secretory ribonucleaseribonuclease 2ribonuclease A F3ribonuclease US | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 131410 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169385 | ||
| HPRD : 00577 | ||
| Vega : OTTHUMG00000029607 | ||
| Protein | UniProt: P10153 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RNASE2 | |
| BioGPS: 6036 | ||
| Pathway | NCI Pathway Interaction Database: RNASE2 | |
| KEGG: RNASE2 | ||
| REACTOME: RNASE2 | ||
| Pathway Commons: RNASE2 | ||
| Context | iHOP: RNASE2 | |
| ligand binding site mutation search in PubMed: RNASE2 | ||
| UCL Cancer Institute: RNASE2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006935 | chemotaxis | 12855582 |
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| Ligand binding site mutations for RNASE2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V155 | V155F | COAD | 1 | H42 | N44I | LUAD | 1 | K28 | K28N | LUAD | 1 | D158 | I160M | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RNASE2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D158 | I160M | -1.3189838 | H42 | N44I | -0.96119116 | V155 | V155F | -0.95856107 | K28 | K28N | -0.74583698 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RNASE2 from PDB |
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| Differential gene expression and gene-gene network for RNASE2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RNASE2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RNASE2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01812 | Adenosine-3'-5'-Diphosphate | Small molecule |  |
| Experimental | DB02098 | Adenosine-2'-5'-Diphosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RNASE2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of RNASE2 |
| Multiple alignments for P10153 in multiple species |
| LBS | AA sequence | # species | Species | A137 | MFYIVACDNRD | 2 | Homo sapiens, Pan troglodytes | A137 | KSYTVACNPRT | 1 | Mus musculus | C89 | NPNMTCPSNKT | 2 | Homo sapiens, Pan troglodytes | C89 | NPPKTC-KDGT | 1 | Mus musculus | D139 | YIVACDNRDQR | 2 | Homo sapiens, Pan troglodytes | D139 | YTVACNPRTP- | 1 | Mus musculus | D158 | VPVHLDRII | 2 | Homo sapiens, Pan troglodytes | D158 | VPVHLDRLF | 1 | Mus musculus | H109 | QVPLIHCNLTT | 2 | Homo sapiens, Pan troglodytes | H109 | KVSVTICKLTK | 1 | Mus musculus | H156 | PVVPVHLDRII | 2 | Homo sapiens, Pan troglodytes | H156 | PVVPVHLDRLF | 1 | Mus musculus | H42 | WFETQHI-NMT | 2 | Homo sapiens, Pan troglodytes | H42 | KFDIQHIYKKS | 1 | Mus musculus | K28 | GSLHVKPPQFT | 2 | Homo sapiens, Pan troglodytes | K28 | VSCQRPTP--- | 1 | Mus musculus | K65 | YQRRCKNQNTF | 2 | Homo sapiens, Pan troglodytes | K65 | YTGKCKDLNTF | 1 | Mus musculus | L157 | VVPVHLDRII | 2 | Homo sapiens, Pan troglodytes | L157 | VVPVHLDRLF | 1 | Mus musculus | N66 | QRRCKNQNTFL | 2 | Homo sapiens, Pan troglodytes | N66 | TGKCKDLNTFL | 1 | Mus musculus | N97 | NKTRKNCHHSG | 1 | Homo sapiens | N97 | DGTSPNCHDSS | 1 | Mus musculus | N97 | NKTRKNCHQSG | 1 | Pan troglodytes | Q41 | QWFETQHI-NM | 2 | Homo sapiens, Pan troglodytes | Q41 | QKFDIQHIYKK | 1 | Mus musculus | Q67 | RRCKNQNTFLL | 2 | Homo sapiens, Pan troglodytes | Q67 | GKCKDLNTFLH | 1 | Mus musculus | R63 | NNYQRRCKNQN | 2 | Homo sapiens, Pan troglodytes | R63 | NKYTGKCKDLN | 1 | Mus musculus | R95 | PSNKTRKNCHH | 1 | Homo sapiens | R95 | -KDGTSPNCHD | 1 | Mus musculus | R95 | PSNKTRKNCHQ | 1 | Pan troglodytes | V155 | YPVVPVHLDRI | 2 | Homo sapiens, Pan troglodytes | V155 | YPVVPVHLDRL | 1 | Mus musculus | W34 | PPQFTWAQWFE | 2 | Homo sapiens, Pan troglodytes | W34 | TP----SQKFD | 1 | Mus musculus |
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