mutLBSgeneDB |
Gene summary for RNASE4 |
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Basic gene Info. | Gene symbol | RNASE4 |
Gene name | ribonuclease, RNase A family, 4 | |
Synonyms | RAB1|RNS4 | |
Cytomap | UCSC genome browser: 14q11 | |
Type of gene | protein-coding | |
RefGenes | NM_001282192.1, NM_001282193.1,NM_002937.4,NM_194431.2,NM_194430.1, | |
Description | RNase 4ribonuclease 4ribonuclease A B1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000258818 | ||
HPRD : 03018 | ||
Vega : OTTHUMG00000029575 | ||
Protein | UniProt: P34096 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNASE4 | |
BioGPS: 6038 | ||
Pathway | NCI Pathway Interaction Database: RNASE4 | |
KEGG: RNASE4 | ||
REACTOME: RNASE4 | ||
Pathway Commons: RNASE4 | ||
Context | iHOP: RNASE4 | |
ligand binding site mutation search in PubMed: RNASE4 | ||
UCL Cancer Institute: RNASE4 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for RNASE4 |
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LBS | AAchange of nsSNV | Cancer type | # samples | R129 | R129T | BLCA | 1 | R129 | V131I | COAD | 1 | R129 | R130C | GBM | 1 | G19 | G19E | LUAD | 1 | F145 | G147D | SKCM | 1 | Q39 | R38Q | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RNASE4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R129 | R130C | -1.0776191 | R129 | R129T | -1.0670892 | F145 | G147D | -0.92200932 | Q39 | R38Q | -0.82638079 | G19 | G19E | -0.63493091 | R129 | V131I | -0.62698526 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for RNASE4 |
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Phenotype information for RNASE4 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RNASE4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB03448 | 2'-Deoxyuridine 3'-Monophosphate | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of RNASE4 |
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LBS | AA sequence | # species | Species | D30 | PSYGQDGMYQR | 2 | Homo sapiens, Pan troglodytes | D30 | PSYGQDRMYQR | 1 | Rattus norvegicus | F145 | QVPVHFDG | 2 | Homo sapiens, Pan troglodytes | F145 | EVPVHFDR | 1 | Rattus norvegicus | F70 | YHCKRFNTFIH | 2 | Homo sapiens, Pan troglodytes | F70 | TQCKRFNTFIH | 1 | Rattus norvegicus | G19 | LLTLLGLGLVQ | 3 | Homo sapiens, Pan troglodytes, Rattus norvegicus | H144 | PQVPVHFDG | 2 | Homo sapiens, Pan troglodytes | H144 | PEVPVHFDR | 1 | Rattus norvegicus | H40 | RFLRQHVHPEE | 2 | Homo sapiens, Pan troglodytes | H40 | RFLRQHVDPEG | 1 | Rattus norvegicus | K68 | TLYHCKRFNTF | 2 | Homo sapiens, Pan troglodytes | K68 | TSTQCKRFNTF | 1 | Rattus norvegicus | N71 | HCKRFNTFIHE | 2 | Homo sapiens, Pan troglodytes | N71 | QCKRFNTFIHE | 1 | Rattus norvegicus | Q39 | QRFLRQHVHPE | 2 | Homo sapiens, Pan troglodytes | Q39 | QRFLRQHVDPE | 1 | Rattus norvegicus | R129 | AIASTRRVVIA | 1 | Homo sapiens | R129 | AMASTRRVVIA | 1 | Pan troglodytes | R129 | ARASTRRVVIA | 1 | Rattus norvegicus | R35 | DGMYQRFLRQH | 2 | Homo sapiens, Pan troglodytes | R35 | DRMYQRFLRQH | 1 | Rattus norvegicus | T72 | CKRFNTFIHED | 3 | Homo sapiens, Pan troglodytes, Rattus norvegicus |
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