mutLBSgeneDB |
Gene summary for RNF4 |
![]() |
Basic gene Info. | Gene symbol | RNF4 |
Gene name | ring finger protein 4 | |
Synonyms | SLX5|SNURF | |
Cytomap | UCSC genome browser: 4p16.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001185009.2, NM_001185010.2,NM_002938.4, | |
Description | E3 ubiquitin ligase RNF4E3 ubiquitin-protein ligase RNF4small nuclear RING finger protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 602850 | |
HGNC : HGNC | ||
Ensembl : ENSG00000063978 | ||
HPRD : 04167 | ||
Vega : OTTHUMG00000160516 | ||
Protein | UniProt: P78317 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF4 | |
BioGPS: 6047 | ||
Pathway | NCI Pathway Interaction Database: RNF4 | |
KEGG: RNF4 | ||
REACTOME: RNF4 | ||
Pathway Commons: RNF4 | ||
Context | iHOP: RNF4 | |
ligand binding site mutation search in PubMed: RNF4 | ||
UCL Cancer Institute: RNF4 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12885770 | GO:0046685 | response to arsenic-containing substance | 20943951 |
Top |
Ligand binding site mutations for RNF4 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | C162 | R164C | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for RNF4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C162 | R164C | -0.83573551 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for RNF4 |
![]() |
![]() |
Top |
Top |
Phenotype information for RNF4 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for RNF4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of RNF4 |
![]() |
LBS | AA sequence | # species | Species | C132 | SGTVSCPICMD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C135 | VSCPICMDGYS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C154 | IVSTECGHVFC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C159 | CGHVFCSQCLR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C162 | VFCSQCLRDSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C173 | KNANTCPTCRK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C176 | NTCPTCRKKIN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H156 | STECGHVFCSQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |