mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for APOBEC3G
Gene summary
Basic gene Info.Gene symbolAPOBEC3G
Gene nameapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
CytomapUCSC genome browser: 22q13.1-q13.2
Type of geneprotein-coding
DescriptionAPOBEC-related cytidine deaminaseAPOBEC-related protein 9DNA dC->dU editing enzymeDNA dC->dU-editing enzyme APOBEC-3Gapolipoprotein B editing enzyme catalytic polypeptide-like 3Gapolipoprotein B mRNA editing enzyme cytidine deaminaseapolipoprotein B
Modification date20141222
dbXrefs MIM : 607113
Ensembl : ENSG00000239713
HPRD : 06172
Vega : OTTHUMG00000151081
ProteinUniProt: Q9HC16
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_APOBEC3G
BioGPS: 60489
PathwayNCI Pathway Interaction Database: APOBEC3G
Pathway Commons: APOBEC3G
ligand binding site mutation search in PubMed: APOBEC3G
UCL Cancer Institute: APOBEC3G
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0002230positive regulation of defense response to virus by host17121840
GO:0009972cytidine deamination16378963
GO:0010529negative regulation of transposition16527742
GO:0045071negative regulation of viral genome replication16378963
GO:0045087innate immune response17121840
GO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate16571802
GO:0048525negative regulation of viral process17121840
GO:0051607defense response to virus12808465
GO:0070383DNA cytosine deamination16527742

Ligand binding site mutations for APOBEC3G

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for APOBEC3G
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for APOBEC3G from PDB

Differential gene expression and gene-gene network for APOBEC3G
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of APOBEC3G and the right PPI network was created from samples without mutations in the LBS of APOBEC3G. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for APOBEC3G
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for APOBEC3G
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of APOBEC3G go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of APOBEC3G
Multiple alignments for Q9HC16 in multiple species
LBSAA sequence# speciesSpecies

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