mutLBSgeneDB |
Gene summary for RPS14 |
Gene summary |
Basic gene Info. | Gene symbol | RPS14 |
Gene name | ribosomal protein S14 | |
Synonyms | EMTB|S14 | |
Cytomap | UCSC genome browser: 5q31-q33 | |
Type of gene | protein-coding | |
RefGenes | NM_001025070.1, NM_001025071.1,NM_005617.3, | |
Description | 40S ribosomal protein S14emetine resistance | |
Modification date | 20141207 | |
dbXrefs | MIM : 130620 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164587 | ||
HPRD : 00562 | ||
Vega : OTTHUMG00000130080 | ||
Protein | UniProt: P62263 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RPS14 | |
BioGPS: 6208 | ||
Pathway | NCI Pathway Interaction Database: RPS14 | |
KEGG: RPS14 | ||
REACTOME: RPS14 | ||
Pathway Commons: RPS14 | ||
Context | iHOP: RPS14 | |
ligand binding site mutation search in PubMed: RPS14 | ||
UCL Cancer Institute: RPS14 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 7867928 |
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Ligand binding site mutations for RPS14 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Y72 | A74G | BRCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RPS14 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y72 | A74G | -0.78807999 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for RPS14 from PDB |
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Differential gene expression and gene-gene network for RPS14 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for RPS14 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0740302 | 5q- syndrome | 18 | Biomarker |
umls:C0003130 | Anoxia | 1 | Biomarker |
umls:C0007097 | Carcinoma | 1 | Biomarker |
umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RPS14 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of RPS14 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 5a2q | O | Y72 | NUC | Nucleic Acids | 5flx | O | Y72 |
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Conservation information for LBS of RPS14 |
Multiple alignments for P62263 in multiple species |
LBS | AA sequence | # species | Species | A64 | GMKVKADRDES | 10 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevis | A64 | GMKVKTDRDES | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A64 | GIKVKADRDES | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | D67 | VKADRDESSPY | 11 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Kluyveromyces lactis (strain AT | D67 | VKTDRDESSPY | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L17 | EQVISLGPQVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L17 | ----NVGPQIR | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L17 | E-NISLGPQIR | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | L17 | QAVVSLGPQAK | 1 | Caenorhabditis elegans | L17 | E-NVTLGPAVR | 1 | Arabidopsis thaliana | L17 | D-VVTLGPSVR | 1 | Arabidopsis thaliana | L17 | E-TVTLGPSVR | 1 | Arabidopsis thaliana | L17 | ------VVQAK | 1 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | L17 | ----DL-VQAR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L17 | ------VVQAR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P71 | RDESSPYAAML | 13 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (stra | R66 | KVKADRDESSP | 11 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Kluyveromyces lactis (strain AT | R66 | KVKTDRDESSP | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S70 | DRDESSPYAAM | 13 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (stra | V62 | TGGMKVKADRD | 10 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevis | V62 | TGGMKVKTDRD | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V62 | IGGIKVKADRD | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Y72 | DESSPYAAMLA | 13 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (stra |
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