mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RPS15
Gene summary
Basic gene Info.Gene symbolRPS15
Gene nameribosomal protein S15
SynonymsRIG|S15
CytomapUCSC genome browser: 19p13.3
Type of geneprotein-coding
RefGenesNM_001018.3,
Description40S ribosomal protein S15homolog of rat insulinomainsulinoma protein
Modification date20141207
dbXrefs MIM : 180535
HGNC : HGNC
Ensembl : ENSG00000115268
HPRD : 01613
Vega : OTTHUMG00000140099
ProteinUniProt: P62841
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RPS15
BioGPS: 6209
PathwayNCI Pathway Interaction Database: RPS15
KEGG: RPS15
REACTOME: RPS15
Pathway Commons: RPS15
ContextiHOP: RPS15
ligand binding site mutation search in PubMed: RPS15
UCL Cancer Institute: RPS15
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001649osteoblast differentiation16210410


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Ligand binding site mutations for RPS15

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K52,R50R51WUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RPS15
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K52R51W-0.79173158
R50R51W-0.79173158
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RPS15 from PDB

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Differential gene expression and gene-gene network for RPS15
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RPS15 and the right PPI network was created from samples without mutations in the LBS of RPS15. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RPS15
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0242656Disease Progression1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RPS15
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RPS15 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids2zkqsR50 K52


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Conservation information for LBS of RPS15
Multiple alignments for P62841 in multiple species
LBSAA sequence# speciesSpecies
G48RRLNRGLRRKQ5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
G48RRFSRGLTRKP4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G48RRMLRGLGPNA2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G48RRFARGMTSKP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G48RRMSRGLTRKP1Arabidopsis thaliana
H54LRRKQHSLLKR5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
H54LTRKPMALIKK5Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H54LGPNASRFIRK2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H54MTSKPAGFMKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I121LGEFSITYKPV5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
I121LAEFSISYKPV4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I121LGEFSITYKPT2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I121LGEFSITYTPV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I121LAEFSITYKPV1Arabidopsis thaliana
K124FSITYKPVKHG5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
K124FSISYKPVKHG4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K124FSITYKPTKHG2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K124FSITYTPVRHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K124FSITYKPVRHG1Arabidopsis thaliana
K52RGLRRKQHSLL5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
K52RGLTRKPMALI5Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K52RGLGPNASRFI2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K52RGMTSKPAGFM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K58QHSLLKRLRKA5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
K58PMALIKKLRKA5Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K58ASRFIRKLRKA2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K58PAGFMKKLRAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N46QRRRLNRGLRR5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
N46IRRRFSRGLTR4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
N46ARRRMLRGLGP2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N46VRRRFARGMTS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N46IRRRMSRGLTR1Arabidopsis thaliana
Q53GLRRKQHSLLK5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
Q53GLTRKPMALIK5Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Q53GLGPNASRFIR2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q53GMTSKPAGFMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R44ARQRRRLNRGL5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
R44SRIRRRFSRGL4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R44ARARRRMLRGL2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R44ARVRRRFARGM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R44SRIRRRMSRGL1Arabidopsis thaliana
R50LNRGLRRKQHS5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
R50FSRGLTRKPMA4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R50MLRGLGPNASR2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R50FARGMTSKPAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R50MSRGLTRKPMA1Arabidopsis thaliana
R61LLKRLRKAKKE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R61LIKKLRKAKRE2Arabidopsis thaliana, Arabidopsis thaliana
R61FMKKLRAAKLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R61FIRKLRKAKTE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R61FIRKLRKAKSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R61LLKRLRKAKKD1Bos taurus
R61LIKKLRKAKLD1Arabidopsis thaliana
R61LIKKLRKAKIE1Arabidopsis thaliana
R61LIKKLRKAKME1Arabidopsis thaliana
T122GEFSITYKPVK5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
T122AEFSISYKPVK4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T122GEFSITYKPTK2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T122GEFSITYTPVR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T122AEFSITYKPVR1Arabidopsis thaliana
Y123EFSITYKPVKH5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
Y123EFSISYKPVKH4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Y123EFSITYKPTKH2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y123EFSITYTPVRH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y123EFSITYKPVRH1Arabidopsis thaliana


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