mutLBSgeneDB |
Gene summary for RRAS |
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Basic gene Info. | Gene symbol | RRAS |
Gene name | related RAS viral (r-ras) oncogene homolog | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_006270.3, | |
Description | Oncogene RRASp23ras-related protein R-Ras | |
Modification date | 20141222 | |
dbXrefs | MIM : 165090 | |
HGNC : HGNC | ||
Ensembl : ENSG00000126458 | ||
HPRD : 01299 | ||
Vega : OTTHUMG00000183247 | ||
Protein | UniProt: P10301 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RRAS | |
BioGPS: 6237 | ||
Pathway | NCI Pathway Interaction Database: RRAS | |
KEGG: RRAS | ||
REACTOME: RRAS | ||
Pathway Commons: RRAS | ||
Context | iHOP: RRAS | |
ligand binding site mutation search in PubMed: RRAS | ||
UCL Cancer Institute: RRAS | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for RRAS |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | S56 | Y58C | UCEC | 1 | N142 | V140F | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RRAS |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S56 | Y58C | -1.4454552 | N142 | V140F | -0.75163973 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for RRAS |
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Phenotype information for RRAS |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RRAS |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2fn4 | A | S56 N142 |
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Conservation information for LBS of RRAS |
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LBS | AA sequence | # species | Species | A173 | YFEASAKLRLN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A44 | GVGKSALTIQF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D145 | VGNKADLESQR | 1 | Homo sapiens | D145 | VGNKADLENQR | 1 | Mus musculus | D145 | VGNKADLETQR | 1 | Rattus norvegicus | G39 | VVGGGGVGKSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G41 | GGGGVGKSALT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K143 | VLVGNKADLES | 1 | Homo sapiens | K143 | VLVGNKADLEN | 1 | Mus musculus | K143 | VLVGNKADLET | 1 | Rattus norvegicus | K174 | FEASAKLRLNV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K42 | GGGVGKSALTI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L146 | GNKADLESQRQ | 1 | Homo sapiens | L146 | GNKADLENQRQ | 1 | Mus musculus | L146 | GNKADLETQRQ | 1 | Rattus norvegicus | N142 | IVLVGNKADLE | 2 | Mus musculus, Rattus norvegicus | N142 | VVLVGNKADLE | 1 | Homo sapiens | S172 | TYFEASAKLRL | 2 | Mus musculus, Rattus norvegicus | S172 | AYFEASAKLRL | 1 | Homo sapiens | S43 | GGVGKSALTIQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S56 | QSYFVSDYDPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V40 | VGGGGVGKSAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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