mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for RRM1

Gene summary

Basic gene Info.	Gene symbol	RRM1
	Gene name	ribonucleotide reductase M1
	Synonyms	R1\|RIR1\|RR1
	Cytomap	UCSC genome browser: 11p15.5
	Type of gene	protein-coding
	RefGenes	NM_001033.3,
	Description	ribonucleoside-diphosphate reductase large subunitribonucleoside-diphosphate reductase subunit M1ribonucleotide reductase M1 polypeptideribonucleotide reductase, R1 subunit
	Modification date	20141207
dbXrefs	MIM : 180410
	HGNC : HGNC
	Ensembl : ENSG00000167325
	HPRD : 01588
	Vega : OTTHUMG00000133361
Protein	UniProt: P23921 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RRM1
	BioGPS: 6240
Pathway	NCI Pathway Interaction Database: RRM1
	KEGG: RRM1
	REACTOME: RRM1
	Pathway Commons: RRM1
Context	iHOP: RRM1
	ligand binding site mutation search in PubMed: RRM1
	UCL Cancer Institute: RRM1
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

Top

Ligand binding site mutations for RRM1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E431	E431D	KIRC	1
G295,R293	P294L	LUAD	1
R21	I22F	LUAD	1
S49	G50V	LUSC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for RRM1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R21	I22F	-1.1827444
E431	E431D	-0.86282878
S49	G50V	-0.54545046
R293	P294L	-0.23071275
G295	P294L	-0.23071275

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RRM1 from PDB

Top

Differential gene expression and gene-gene network for RRM1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of RRM1 and the right PPI network was created from samples without mutations in the LBS of RRM1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for RRM1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0007131	Carcinoma, Non-Small-Cell Lung	39	Biomarker, GeneticVariation
umls:C0206686	Adrenocortical Carcinoma	1	Biomarker
umls:C2239176	Carcinoma, Hepatocellular	1	Biomarker
umls:C0242656	Disease Progression	1	Biomarker
umls:C0027794	Neural Tube Defects	1	Biomarker
umls:C0031117	Peripheral Nervous System Diseases	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

Top

Pharmacological information for RRM1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|investigational	DB00242	Cladribine	Small molecule
Approved	DB00441	Gemcitabine	Small molecule
Approved\|investigational	DB00631	Clofarabine	Small molecule
Approved	DB01005	Hydroxyurea	Small molecule
Approved	DB01073	Fludarabine	Small molecule
Investigational	DB05003	Imexon	Small molecule
Investigational	DB05420	gallium maltolate	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RRM1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
GDP		GUANOSINE-5'-DIPHOSPHATE	3hnd	A	G295 E431
DTP		DATP(4-)	3hnf	B	R21
GDP		GUANOSINE-5'-DIPHOSPHATE	3hnd	B	R293 E431
3X4		N~6~-{N-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ACETYL]-2-METHYL-D-ALANYL}-D-LYSINE	4x3v	A	S49

Top

Conservation information for LBS of RRM1

Multiple alignments for P23921 in multiple species

LBS	AA sequence	# species	Species
A201	RYFTHASPTLF	3	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A201	RWFTHASPTLF	2	Homo sapiens, Arabidopsis thaliana
A201	RYMTHASPTLF	1	Caenorhabditis elegans
A201	KWFTHASPTLF	1	Mus musculus
A201	KYFTHASPTLF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A201	KTFTHASPTLF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A245	LISKSAGGIGV	2	Homo sapiens, Mus musculus
A245	VISKSAGGIGV	1	Arabidopsis thaliana
A245	LISKSAGGIGL	1	Caenorhabditis elegans
A245	MISKSAGGIGL	1	Drosophila melanogaster
A245	LISKTAGGIGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A245	MISKTAGGVGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A245	MISKMAGGIGL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A245	MISKTAGGIGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A263	TGSYIAGTNGT	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A263	TGSYIAGTNGN	2	Homo sapiens, Mus musculus
A263	TGSYIRGTNGT	1	Arabidopsis thaliana
A263	TGSVIAGTNGT	1	Caenorhabditis elegans
A263	KGTSICGTNGT	1	Drosophila melanogaster
A296	NKRPGAFAIYL	4	Homo sapiens, Caenorhabditis elegans, Mus musculus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A296	GKRKGAFAVYL	1	Arabidopsis thaliana
A296	GKRPGAFAIYL	1	Drosophila melanogaster
A296	NKRPGAFALYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A296	NKRPGAFALFL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A296	NKRPGAFAAYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A605	APMPTASTSQI	5	Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 97
A605	APMPTASTAQI	4	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
C218	PQLSSCFLLSM	2	Homo sapiens, Mus musculus
C218	PQLSSCFLVCM	1	Arabidopsis thaliana
C218	PQMSSCFLLTM	1	Caenorhabditis elegans
C218	PQLSSCFLLTM	1	Drosophila melanogaster
C218	PQMSSCFLVAM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C218	PQMSSCFLIAM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C218	PQLSSCFLVDM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C218	PQLSSCFLVTM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C429	KCSNLCTEIVE	3	Homo sapiens, Drosophila melanogaster, Mus musculus
C429	KSSNLCCEIVE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C429	KSSNLCTEIIE	1	Arabidopsis thaliana
C429	KCSNLCTEIIE	1	Caenorhabditis elegans
C429	RSSNLCTEIIE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C429	RCSNLCTEIVE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D226	LSMKDDSIEGI	2	Homo sapiens, Mus musculus
D226	VCMKDDSIEGI	1	Arabidopsis thaliana
D226	LTMSEDSILGI	1	Caenorhabditis elegans
D226	LTMTADSIEGI	1	Drosophila melanogaster
D226	VAMKEDSIEGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D226	IAMKDDSIEGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D226	VDMKEDSIEGI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D226	VTMKDDSIEGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D287	TARYVDQGGNK	7	Homo sapiens, Caenorhabditis elegans, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizo
D287	TARYVDQGGGK	1	Arabidopsis thaliana
D287	VARYVDQGGGK	1	Drosophila melanogaster
D57	TTVELDTLAAE	2	Homo sapiens, Mus musculus
D57	TTVELDNLAAE	2	Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D57	TTIELDNLAAE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D57	TTSQLDELAAE	1	Arabidopsis thaliana
D57	TTQELDNLAAE	1	Drosophila melanogaster
D57	TTAQLDDLAAE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E11	RDGRQERVMFD	2	Homo sapiens, Mus musculus
E11	RDGRKEPVQFD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E11	RDGRQETVHFD	1	Arabidopsis thaliana
E11	RDGRKEDVHFD	1	Caenorhabditis elegans
E11	RDGRQEEVHFD	1	Drosophila melanogaster
E11	RDGRQERVQFD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E11	RDGRQEKVAFD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E431	SNLCTEIVEYT	2	Homo sapiens, Mus musculus
E431	SNLCTEIIEYS	2	Caenorhabditis elegans, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E431	SNLCTEIVEYS	2	Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E431	SNLCCEIVEYS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E431	SNLCTEIIEYT	1	Arabidopsis thaliana
G246	ISKSAGGIGVA	2	Homo sapiens, Mus musculus
G246	ISKSAGGIGLN	2	Caenorhabditis elegans, Drosophila melanogaster
G246	ISKSAGGIGVS	1	Arabidopsis thaliana
G246	ISKTAGGIGLH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G246	ISKTAGGVGLH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G246	ISKMAGGIGLN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G246	ISKTAGGIGIN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G247	SKSAGGIGVAV	2	Homo sapiens, Mus musculus
G247	SKSAGGIGLNV	2	Caenorhabditis elegans, Drosophila melanogaster
G247	SKSAGGIGVSV	1	Arabidopsis thaliana
G247	SKTAGGIGLHI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G247	SKTAGGVGLHI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G247	SKMAGGIGLNI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G247	SKTAGGIGINI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G264	GSYIAGTNGTS	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G264	GSYIAGTNGNS	2	Homo sapiens, Mus musculus
G264	GSYIRGTNGTS	1	Arabidopsis thaliana
G264	GSVIAGTNGTS	1	Caenorhabditis elegans
G264	GTSICGTNGTS	1	Drosophila melanogaster
G271	NGNSNGLVPML	2	Homo sapiens, Mus musculus
G271	NGTSNGIVPML	2	Arabidopsis thaliana, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G271	NGTSNGLIPMI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G271	NGTSNGLIPML	1	Caenorhabditis elegans
G271	NGTSNGLVPML	1	Drosophila melanogaster
G271	NGTSNGIVPMI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G295	GNKRPGAFAIY	4	Homo sapiens, Caenorhabditis elegans, Mus musculus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G295	GGKRKGAFAVY	1	Arabidopsis thaliana
G295	GGKRPGAFAIY	1	Drosophila melanogaster
G295	GNKRPGAFALY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G295	GNKRPGAFALF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G295	GNKRPGAFAAY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I18	VMFDKITSRIQ	2	Homo sapiens, Mus musculus
I18	VHFDKITSRIQ	2	Caenorhabditis elegans, Drosophila melanogaster
I18	VHFDKITARLK	1	Arabidopsis thaliana
I18	VQFDKITARIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I18	VQFDKITSRIT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I18	VQFDKITARVS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I18	VAFDKITARVS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I228	MKDDSIEGIYD	4	Homo sapiens, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I228	MKEDSIEGIYD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I228	MKDDSIEGIYE	1	Arabidopsis thaliana
I228	MSEDSILGIYD	1	Caenorhabditis elegans
I228	MTADSIEGIFK	1	Drosophila melanogaster
I231	DSIEGIYDTLK	6	Homo sapiens, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (str
I231	DSIEGIYETLK	1	Arabidopsis thaliana
I231	DSILGIYDTLK	1	Caenorhabditis elegans
I231	DSIEGIFKSVE	1	Drosophila melanogaster
I255	VAVSCIRATGS	2	Homo sapiens, Mus musculus
I255	VSVHNIRATGS	1	Arabidopsis thaliana
I255	LNVHKIRATGS	1	Caenorhabditis elegans
I255	LNVHCIRAKGT	1	Drosophila melanogaster
I255	LHIHNIRSTGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I255	LHINNIRSTGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I255	LNIHRIRATGS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I255	INIHNIRATGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I262	ATGSYIAGTNG	4	Homo sapiens, Mus musculus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I262	STGSYIAGTNG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I262	ATGSYIRGTNG	1	Arabidopsis thaliana
I262	ATGSVIAGTNG	1	Caenorhabditis elegans
I262	AKGTSICGTNG	1	Drosophila melanogaster
K17	RVMFDKITSRI	2	Homo sapiens, Mus musculus
K17	TVHFDKITARL	1	Arabidopsis thaliana
K17	DVHFDKITSRI	1	Caenorhabditis elegans
K17	EVHFDKITSRI	1	Drosophila melanogaster
K17	PVQFDKITARI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K17	PVQFDKITSRI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K17	RVQFDKITARV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K17	KVAFDKITARV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K243	CALISKSAGGI	3	Homo sapiens, Caenorhabditis elegans, Mus musculus
K243	CAVISKSAGGI	1	Arabidopsis thaliana
K243	CAMISKSAGGI	1	Drosophila melanogaster
K243	CALISKTAGGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K243	CAMISKTAGGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K243	CAMISKMAGGI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K243	CAMISKTAGGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K5	-MHVIKRDGRQ	2	Homo sapiens, Mus musculus
K5	-MYVVKRDGRQ	1	Arabidopsis thaliana
K5	STYVVKRDGRK	1	Caenorhabditis elegans
K5	KLYVIKRDGRQ	1	Drosophila melanogaster
K5	-MYVYKRDGRK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K5	-MYVIKRDGRK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K5	-MYVKKRDGRQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K5	-MFVYKRDGRQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K88	VSNLHKETKKV	2	Homo sapiens, Mus musculus
K88	ISNLHKQTTKQ	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K88	VSNLHKNTKKS	1	Arabidopsis thaliana
K88	VSNLHKKTNKV	1	Caenorhabditis elegans
K88	VSNLHKETKKA	1	Drosophila melanogaster
K88	VSNLHKQTKKQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K88	VSNLHKQTEKV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L428	IKCSNLCTEIV	3	Homo sapiens, Drosophila melanogaster, Mus musculus
L428	IKSSNLCCEIV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L428	IKSSNLCTEII	1	Arabidopsis thaliana
L428	IKCSNLCTEII	1	Caenorhabditis elegans
L428	IRSSNLCTEII	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L428	IRCSNLCTEIV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L56	VTTVELDTLAA	2	Homo sapiens, Mus musculus
L56	VTTVELDNLAA	2	Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L56	VTTIELDNLAA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L56	VTTSQLDELAA	1	Arabidopsis thaliana
L56	VTTQELDNLAA	1	Drosophila melanogaster
L56	VTTAQLDDLAA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M14	RQERVMFDKIT	2	Homo sapiens, Mus musculus
M14	RKEPVQFDKIT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M14	RQETVHFDKIT	1	Arabidopsis thaliana
M14	RKEDVHFDKIT	1	Caenorhabditis elegans
M14	RQEEVHFDKIT	1	Drosophila melanogaster
M14	RQERVQFDKIT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M14	RQEKVAFDKIT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M602	LLVAPMPTAST	3	Arabidopsis thaliana, Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M602	LLIAPMPTAST	2	Homo sapiens, Mus musculus
M602	LTMAPMPTAST	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M602	LLMAPMPTAST	1	Caenorhabditis elegans
M602	LLLAPMPTAST	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N270	TNGTSNGIVPM	3	Arabidopsis thaliana, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N270	TNGTSNGLIPM	3	Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N270	TNGNSNGLVPM	2	Homo sapiens, Mus musculus
N270	TNGTSNGLVPM	1	Drosophila melanogaster
N427	TIKCSNLCTEI	4	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
N427	TIKSSNLCTEI	1	Arabidopsis thaliana
N427	VIKSSNLCCEI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N427	TIKSSNLCCEI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N427	TIRSSNLCTEI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N427	TIRCSNLCTEI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P603	LIAPMPTASTA	2	Homo sapiens, Mus musculus
P603	LVAPMPTASTS	2	Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P603	TMAPMPTASTS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P603	LMAPMPTASTA	1	Caenorhabditis elegans
P603	LVAPMPTASTA	1	Drosophila melanogaster
P603	LLAPMPTASTS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R12	DGRQERVMFDK	2	Homo sapiens, Mus musculus
R12	DGRKEPVQFDK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R12	DGRQETVHFDK	1	Arabidopsis thaliana
R12	DGRKEDVHFDK	1	Caenorhabditis elegans
R12	DGRQEEVHFDK	1	Drosophila melanogaster
R12	DGRQERVQFDK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R12	DGRQEKVAFDK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R21	DKITSRIQKLC	3	Homo sapiens, Drosophila melanogaster, Mus musculus
R21	DKITARVSRLC	2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R21	DKITARLKKLS	1	Arabidopsis thaliana
R21	DKITSRIQKLS	1	Caenorhabditis elegans
R21	DKITARISRLC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R21	DKITSRITRLS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R256	AVSCIRATGSY	2	Homo sapiens, Mus musculus
R256	SVHNIRATGSY	1	Arabidopsis thaliana
R256	NVHKIRATGSV	1	Caenorhabditis elegans
R256	NVHCIRAKGTS	1	Drosophila melanogaster
R256	HIHNIRSTGSY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R256	HINNIRSTGSY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R256	NIHRIRATGSY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R256	NIHNIRATGSY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R293	QGGNKRPGAFA	7	Homo sapiens, Caenorhabditis elegans, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizo
R293	QGGGKRKGAFA	1	Arabidopsis thaliana
R293	QGGGKRPGAFA	1	Drosophila melanogaster
R6	MHVIKRDGRQE	2	Homo sapiens, Mus musculus
R6	MYVVKRDGRQE	1	Arabidopsis thaliana
R6	TYVVKRDGRKE	1	Caenorhabditis elegans
R6	LYVIKRDGRQE	1	Drosophila melanogaster
R6	MYVYKRDGRKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R6	MYVIKRDGRKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R6	MYVKKRDGRQE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R6	MFVYKRDGRQE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S202	WFTHASPTLFN	3	Homo sapiens, Arabidopsis thaliana, Mus musculus
S202	YFTHASPTLFN	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S202	YMTHASPTLFN	1	Caenorhabditis elegans
S202	YFTHASPTLFA	1	Drosophila melanogaster
S202	TFTHASPTLFN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S217	RPQLSSCFLLS	2	Homo sapiens, Mus musculus
S217	RPQLSSCFLVC	1	Arabidopsis thaliana
S217	RPQMSSCFLLT	1	Caenorhabditis elegans
S217	RPQLSSCFLLT	1	Drosophila melanogaster
S217	KPQMSSCFLVA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S217	HPQMSSCFLIA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S217	QPQLSSCFLVD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S217	RPQLSSCFLVT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S227	SMKDDSIEGIY	2	Homo sapiens, Mus musculus
S227	CMKDDSIEGIY	1	Arabidopsis thaliana
S227	TMSEDSILGIY	1	Caenorhabditis elegans
S227	TMTADSIEGIF	1	Drosophila melanogaster
S227	AMKEDSIEGIY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S227	AMKDDSIEGIY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S227	DMKEDSIEGIY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S227	TMKDDSIEGIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S269	GTNGTSNGIVP	3	Arabidopsis thaliana, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S269	GTNGTSNGLIP	3	Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S269	GTNGNSNGLVP	2	Homo sapiens, Mus musculus
S269	GTNGTSNGLVP	1	Drosophila melanogaster
S49	IQGLYSGVTTV	2	Homo sapiens, Mus musculus
S49	CAGVYKGVTTS	1	Arabidopsis thaliana
S49	ISGLYKGVTTV	1	Caenorhabditis elegans
S49	INGLYCGVTTQ	1	Drosophila melanogaster
S49	ISGVYEGVTTI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S49	ISGVYSGVTTV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S49	ISGVYGGVTTA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S49	ISGVYPGVTTI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S606	PMPTASTSQIL	5	Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 97
S606	PMPTASTAQIL	3	Homo sapiens, Caenorhabditis elegans, Mus musculus
S606	PMPTASTAQIM	1	Drosophila melanogaster
T265	SYIAGTNGTSN	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T265	SYIAGTNGNSN	2	Homo sapiens, Mus musculus
T265	SYIRGTNGTSN	1	Arabidopsis thaliana
T265	SVIAGTNGTSN	1	Caenorhabditis elegans
T265	TSICGTNGTSN	1	Drosophila melanogaster
T53	YSGVTTVELDT	2	Homo sapiens, Mus musculus
T53	YKGVTTSQLDE	1	Arabidopsis thaliana
T53	YKGVTTVELDN	1	Caenorhabditis elegans
T53	YCGVTTQELDN	1	Drosophila melanogaster
T53	YEGVTTIELDN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T53	YSGVTTVELDN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T53	YGGVTTAQLDD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T53	YPGVTTIELDN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T604	IAPMPTASTAQ	2	Homo sapiens, Mus musculus
T604	VAPMPTASTSQ	2	Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T604	MAPMPTASTSQ	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T604	MAPMPTASTAQ	1	Caenorhabditis elegans
T604	VAPMPTASTAQ	1	Drosophila melanogaster
T604	LAPMPTASTSQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T607	MPTASTSQILG	5	Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 97
T607	MPTASTAQILG	3	Homo sapiens, Caenorhabditis elegans, Mus musculus
T607	MPTASTAQIMG	1	Drosophila melanogaster
V286	NTARYVDQGGN	7	Homo sapiens, Caenorhabditis elegans, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizo
V286	DTARYVDQGGG	1	Arabidopsis thaliana
V286	NVARYVDQGGG	1	Drosophila melanogaster
V3	---MHVIKRDG	2	Homo sapiens, Mus musculus
V3	---MYVVKRDG	1	Arabidopsis thaliana
V3	YNSTYVVKRDG	1	Caenorhabditis elegans
V3	TSKLYVIKRDG	1	Drosophila melanogaster
V3	---MYVYKRDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V3	---MYVIKRDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V3	---MYVKKRDG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V3	---MFVYKRDG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y285	NNTARYVDQGG	7	Homo sapiens, Caenorhabditis elegans, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizo
Y285	NDTARYVDQGG	1	Arabidopsis thaliana
Y285	NNVARYVDQGG	1	Drosophila melanogaster
Y48	VIQGLYSGVTT	2	Homo sapiens, Mus musculus
Y48	VCAGVYKGVTT	1	Arabidopsis thaliana
Y48	VISGLYKGVTT	1	Caenorhabditis elegans
Y48	VINGLYCGVTT	1	Drosophila melanogaster
Y48	IISGVYEGVTT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y48	IISGVYSGVTT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y48	VISGVYGGVTT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y48	VISGVYPGVTT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)