mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for S100A4
Gene summary
Basic gene Info.Gene symbolS100A4
Gene nameS100 calcium binding protein A4
Synonyms18A2|42A|CAPL|FSP1|MTS1|P9KA|PEL98
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_002961.2,
NM_019554.2,
DescriptionS100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)fibroblast-specific protein-1leukemia multidrug resistance associated proteinmalignant transformation suppression 1placental calcium-binding proteinpr
Modification date20141222
dbXrefs MIM : 114210
HGNC : HGNC
Ensembl : ENSG00000196154
HPRD : 15914
Vega : OTTHUMG00000013546
ProteinUniProt: P26447
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100A4
BioGPS: 6275
PathwayNCI Pathway Interaction Database: S100A4
KEGG: S100A4
REACTOME: S100A4
Pathway Commons: S100A4
ContextiHOP: S100A4
ligand binding site mutation search in PubMed: S100A4
UCL Cancer Institute: S100A4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling15033494


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Ligand binding site mutations for S100A4

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F93F93VCOAD1
I82,M84A83TKICH1
N65,D67R66MLUAD1
F93D95GLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for S100A4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N65R66M-1.0051846
D67R66M-1.0051846
F93D95G-0.97297449
I82A83T-0.84536253
M84A83T-0.84536253
F93F93V-0.72425382
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for S100A4 from PDB

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Differential gene expression and gene-gene network for S100A4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of S100A4 and the right PPI network was created from samples without mutations in the LBS of S100A4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for S100A4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027627Neoplasm Metastasis116AlteredExpression, Biomarker
umls:C0025149Medulloblastoma2Biomarker
umls:C0009375Colonic Neoplasms1Biomarker
umls:C0022116Ischemia1Biomarker
umls:C0022548Keloid1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0751895Vasospasm, Intracranial1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for S100A4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00831TrifluoperazineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of S100A4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
TFPTRIFLUOPERAZINE3ko0BF93
TFPTRIFLUOPERAZINE3ko0CF93
TFPTRIFLUOPERAZINE3ko0DF93
TFPTRIFLUOPERAZINE3ko0EF93
TFPTRIFLUOPERAZINE3ko0FF93
TFPTRIFLUOPERAZINE3ko0JF93
TFPTRIFLUOPERAZINE3ko0LF93
TFPTRIFLUOPERAZINE3ko0NF93
TFPTRIFLUOPERAZINE3ko0OF93
TFPTRIFLUOPERAZINE3ko0PF93
TFPTRIFLUOPERAZINE3ko0SF93
TFPTRIFLUOPERAZINE3ko0TF93
P77PROCHLORPERAZINE3m0wBF93
P77PROCHLORPERAZINE3m0wJF93
TFPTRIFLUOPERAZINE3ko0AI82
TFPTRIFLUOPERAZINE3ko0BI82
TFPTRIFLUOPERAZINE3ko0CI82
TFPTRIFLUOPERAZINE3ko0DI82
TFPTRIFLUOPERAZINE3ko0FI82
TFPTRIFLUOPERAZINE3ko0GI82
TFPTRIFLUOPERAZINE3ko0HI82
TFPTRIFLUOPERAZINE3ko0HI82
TFPTRIFLUOPERAZINE3ko0JI82
TFPTRIFLUOPERAZINE3ko0KI82
TFPTRIFLUOPERAZINE3ko0MI82
TFPTRIFLUOPERAZINE3ko0NI82
TFPTRIFLUOPERAZINE3ko0OI82
TFPTRIFLUOPERAZINE3ko0PI82
TFPTRIFLUOPERAZINE3ko0QI82
TFPTRIFLUOPERAZINE3ko0RI82
TFPTRIFLUOPERAZINE3ko0SI82
TFPTRIFLUOPERAZINE3ko0TI82
P77PROCHLORPERAZINE3m0wBI82
P77PROCHLORPERAZINE3m0wDI82
P77PROCHLORPERAZINE3m0wEI82
P77PROCHLORPERAZINE3m0wFI82
IIIPeptide ligand (ASP,ALA,THR,GLU,THR,ALA,ASP,ALA,MET,ASN,ARG,GLU,VAL,SER,SER,LEU,LYS,ASN,LYS,LEU,ARG,ARG,GLY,ASP,LEU,PRO,PHE)4cfqBI82
IIIPeptide ligand (ASP,ALA,THR,GLU,THR,ALA,ASP,ALA,MET,ASN,ARG,GLU,VAL,SER,SER,LEU,LYS,ASN,LYS,LEU,ARG,ARG,GLY,ASP,LEU,PRO,PHE,VAL,VAL)4cfqDI82
TFPTRIFLUOPERAZINE3ko0AI82 F93
TFPTRIFLUOPERAZINE3ko0GI82 F93
TFPTRIFLUOPERAZINE3ko0II82 F93
TFPTRIFLUOPERAZINE3ko0KI82 F93
TFPTRIFLUOPERAZINE3ko0QI82 F93
TFPTRIFLUOPERAZINE3ko0RI82 F93
IIIPeptide ligand (ASP,ALA,MET,ASN,ARG,GLU,VAL,SER,SER,LEU,LYS,ASN,LYS,LEU)4etoAM84
IIIPeptide ligand (ASP,ALA,MET,ASN,ARG,GLU,VAL,SER,SER,LEU,LYS,ASN,LYS,LEU)4etoBM84
CACALCIUM(2+)2q91AN65 D67
CACALCIUM(2+)2q91BN65 D67
CACALCIUM(2+)3c1vAN65 D67
CACALCIUM(2+)3c1vBN65 D67
CACALCIUM(2+)3c1vCN65 D67
CACALCIUM(2+)3c1vDN65 D67
CACALCIUM(2+)3cgaAN65 D67
CACALCIUM(2+)3cgaBN65 D67
CACALCIUM(2+)3ko0AN65 D67
CACALCIUM(2+)3ko0BN65 D67
CACALCIUM(2+)3ko0CN65 D67
CACALCIUM(2+)3ko0DN65 D67
CACALCIUM(2+)3ko0EN65 D67
CACALCIUM(2+)3ko0FN65 D67
CACALCIUM(2+)3ko0GN65 D67
CACALCIUM(2+)3ko0HN65 D67
CACALCIUM(2+)3ko0IN65 D67
CACALCIUM(2+)3ko0JN65 D67
CACALCIUM(2+)3ko0KN65 D67
CACALCIUM(2+)3ko0LN65 D67
CACALCIUM(2+)3ko0MN65 D67
CACALCIUM(2+)3ko0NN65 D67
CACALCIUM(2+)3ko0ON65 D67
CACALCIUM(2+)3ko0PN65 D67
CACALCIUM(2+)3ko0QN65 D67
CACALCIUM(2+)3ko0RN65 D67
CACALCIUM(2+)3ko0SN65 D67
CACALCIUM(2+)3ko0TN65 D67
CACALCIUM(2+)3m0wAN65 D67
CACALCIUM(2+)3m0wBN65 D67
CACALCIUM(2+)3m0wCN65 D67
CACALCIUM(2+)3m0wDN65 D67
CACALCIUM(2+)3m0wEN65 D67
CACALCIUM(2+)3m0wFN65 D67
CACALCIUM(2+)3m0wGN65 D67
CACALCIUM(2+)3m0wHN65 D67
CACALCIUM(2+)3m0wIN65 D67
CACALCIUM(2+)3m0wJN65 D67
CACALCIUM(2+)3zwhAN65 D67
CACALCIUM(2+)3zwhBN65 D67
CACALCIUM(2+)4etoAN65 D67
CACALCIUM(2+)4etoBN65 D67
CACALCIUM(2+)4hszAN65 D67
CACALCIUM(2+)4hszBN65 D67
CACALCIUM(2+)4hszCN65 D67
CACALCIUM(2+)4hszDN65 D67
CACALCIUM(2+)4cfqAN65 D67
CACALCIUM(2+)4cfqBN65 D67
CACALCIUM(2+)4cfqCN65 D67
CACALCIUM(2+)4cfqDN65 D67
CACALCIUM(2+)4cfrAN65 D67
CACALCIUM(2+)4cfrBN65 D67


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Conservation information for LBS of S100A4
Multiple alignments for P26447 in multiple species
LBSAA sequence# speciesSpecies
A54RTDEAAFQKLM3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
A54RTDEAAFQKVM1Mus musculus
A54RTDETAFQKLM1Bos taurus
C81CVFLSCIAMMC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C81CVFLSCVAMMC1Canis lupus familiaris
C86CIAMMCNEFFE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C86CVAMMCNEFFE1Canis lupus familiaris
D10LEKALDVMVST3Homo sapiens, Canis lupus familiaris, Bos taurus
D10LEEALDVIVST2Mus musculus, Rattus norvegicus
D25SGKEGDKFKLN4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
D25SGNEGDKFKLN1Rattus norvegicus
D63LMSNLDSNRDN2Homo sapiens, Canis lupus familiaris
D63VMSNLDSNRDN1Mus musculus
D63LMNNLDSNRDN1Rattus norvegicus
D63LMSNLDCNKDN1Bos taurus
D67LDSNRDNEVDF4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
D67LDCNKDNEVDF1Bos taurus
D71RDNEVDFQEYC4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
D71KDNEVDFQEYC1Bos taurus
E23KYSGKEGDKFK4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
E23KYSGNEGDKFK1Rattus norvegicus
E33KLNKSELKELL2Homo sapiens, Bos taurus
E33KLNKTELKELL2Mus musculus, Rattus norvegicus
E33KLNRSELKELL1Canis lupus familiaris
E6MARPLEEALDV2Mus musculus, Rattus norvegicus
E6MACPLEKALDV1Homo sapiens
E6MTFPLEKALDV1Canis lupus familiaris
E6MAYPLEKALDV1Bos taurus
E69SNRDNEVDFQE4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
E69CNKDNEVDFQE1Bos taurus
E74EVDFQEYCVFL5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
E88AMMCNEFFEGF3Homo sapiens, Canis lupus familiaris, Bos taurus
E88AMMCNEFFEGC2Mus musculus, Rattus norvegicus
F16VMVSTFHKYSG3Homo sapiens, Canis lupus familiaris, Bos taurus
F16VIVSTFHKYSG2Mus musculus, Rattus norvegicus
F45RELPSFLGKRT4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
F45RELPSFLGRRT1Rattus norvegicus
F55TDEAAFQKLMS2Homo sapiens, Canis lupus familiaris
F55TDEAAFQKVMS1Mus musculus
F55TDEAAFQKLMN1Rattus norvegicus
F55TDETAFQKLMS1Bos taurus
F78QEYCVFLSCIA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F78QEYCVFLSCVA1Canis lupus familiaris
F89MMCNEFFEGFP3Homo sapiens, Canis lupus familiaris, Bos taurus
F89MMCNEFFEGCP2Mus musculus, Rattus norvegicus
F90MCNEFFEGFPD3Homo sapiens, Canis lupus familiaris, Bos taurus
F90MCNEFFEGCPD2Mus musculus, Rattus norvegicus
F93EFFEGFPDKQP3Homo sapiens, Canis lupus familiaris, Bos taurus
F93EFFEGCPDKEP2Mus musculus, Rattus norvegicus
G21FHKYSGKEGDK4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
G21FHKYSGNEGDK1Rattus norvegicus
G24YSGKEGDKFKL4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
G24YSGNEGDKFKL1Rattus norvegicus
G47LPSFLGKRTDE4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
G47LPSFLGRRTDE1Rattus norvegicus
I82VFLSCIAMMCN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I82VFLSCVAMMCN1Canis lupus familiaris
K22HKYSGKEGDKF4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
K22HKYSGNEGDKF1Rattus norvegicus
K28EGDKFKLNKSE2Homo sapiens, Bos taurus
K28EGDKFKLNKTE2Mus musculus, Rattus norvegicus
K28EGDKFKLNRSE1Canis lupus familiaris
K48PSFLGKRTDEA3Homo sapiens, Mus musculus, Canis lupus familiaris
K48PSFLGRRTDEA1Rattus norvegicus
K48PSFLGKRTDET1Bos taurus
K57EAAFQKLMSNL2Homo sapiens, Canis lupus familiaris
K57EAAFQKVMSNL1Mus musculus
K57EAAFQKLMNNL1Rattus norvegicus
K57ETAFQKLMSNL1Bos taurus
L29GDKFKLNKSEL2Homo sapiens, Bos taurus
L29GDKFKLNKTEL2Mus musculus, Rattus norvegicus
L29GDKFKLNRSEL1Canis lupus familiaris
L42LLTRELPSFLG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L42LLMRELPSFLG1Canis lupus familiaris
L46ELPSFLGKRTD4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
L46ELPSFLGRRTD1Rattus norvegicus
L58AAFQKLMSNLD2Homo sapiens, Canis lupus familiaris
L58AAFQKVMSNLD1Mus musculus
L58AAFQKLMNNLD1Rattus norvegicus
L58TAFQKLMSNLD1Bos taurus
L62KLMSNLDSNRD2Homo sapiens, Canis lupus familiaris
L62KVMSNLDSNRD1Mus musculus
L62KLMNNLDSNRD1Rattus norvegicus
L62KLMSNLDCNKD1Bos taurus
L9PLEKALDVMVS3Homo sapiens, Canis lupus familiaris, Bos taurus
L9PLEEALDVIVS2Mus musculus, Rattus norvegicus
M84LSCIAMMCNEF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M84LSCVAMMCNEF1Canis lupus familiaris
M85SCIAMMCNEFF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M85SCVAMMCNEFF1Canis lupus familiaris
N30DKFKLNKSELK2Homo sapiens, Bos taurus
N30DKFKLNKTELK2Mus musculus, Rattus norvegicus
N30DKFKLNRSELK1Canis lupus familiaris
N61QKLMSNLDSNR2Homo sapiens, Canis lupus familiaris
N61QKVMSNLDSNR1Mus musculus
N61QKLMNNLDSNR1Rattus norvegicus
N61QKLMSNLDCNK1Bos taurus
N65SNLDSNRDNEV3Homo sapiens, Mus musculus, Canis lupus familiaris
N65NNLDSNRDNEV1Rattus norvegicus
N65SNLDCNKDNEV1Bos taurus
Q73NEVDFQEYCVF5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
S14LDVMVSTFHKY3Homo sapiens, Canis lupus familiaris, Bos taurus
S14LDVIVSTFHKY2Mus musculus, Rattus norvegicus
S20TFHKYSGKEGD4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
S20TFHKYSGNEGD1Rattus norvegicus
S44TRELPSFLGKR3Homo sapiens, Mus musculus, Bos taurus
S44TRELPSFLGRR1Rattus norvegicus
S44MRELPSFLGKR1Canis lupus familiaris
S64MSNLDSNRDNE3Homo sapiens, Mus musculus, Canis lupus familiaris
S64MNNLDSNRDNE1Rattus norvegicus
S64MSNLDCNKDNE1Bos taurus
S80YCVFLSCIAMM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S80YCVFLSCVAMM1Canis lupus familiaris
T50FLGKRTDEAAF3Homo sapiens, Mus musculus, Canis lupus familiaris
T50FLGRRTDEAAF1Rattus norvegicus
T50FLGKRTDETAF1Bos taurus
V70NRDNEVDFQEY4Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris
V70NKDNEVDFQEY1Bos taurus
V77FQEYCVFLSCI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V77FQEYCVFLSCV1Canis lupus familiaris


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