mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for S100A7
Gene summary
Basic gene Info.Gene symbolS100A7
Gene nameS100 calcium binding protein A7
SynonymsPSOR1|S100A7c
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_002963.3,
DescriptionS100 calcium-binding protein A7 (psoriasin 1)protein S100-A7psoriasin 1
Modification date20141207
dbXrefs MIM : 600353
HGNC : HGNC
Ensembl : ENSG00000143556
HPRD : 02645
Vega : OTTHUMG00000013123
ProteinUniProt: P31151
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100A7
BioGPS: 6278
PathwayNCI Pathway Interaction Database: S100A7
KEGG: S100A7
REACTOME: S100A7
Pathway Commons: S100A7
ContextiHOP: S100A7
ligand binding site mutation search in PubMed: S100A7
UCL Cancer Institute: S100A7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000302response to reactive oxygen species16082188
GO:0010820positive regulation of T cell chemotaxis18606705
GO:0051238sequestering of metal ion15568027
GO:0070374positive regulation of ERK1 and ERK2 cascade18606705
GO:0071624positive regulation of granulocyte chemotaxis18606705
GO:0090026positive regulation of monocyte chemotaxis18606705


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Ligand binding site mutations for S100A7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D67D67NCOAD1
D67,K69K68NCOAD1
H91G92RSKCM1
H91G92VSKCM1
H18H18NSKCM1
N65N65HSTAD1
H91G92RTHCA1
D63D63YUCEC1
D67,K69K68NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for S100A7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D67D67N-1.9337704
K69K68N-1.2633066
D67K68N-1.2633066
H18H18N-1.0724492
N65N65H-0.81213066
D63D63Y-0.7480611
H91G92V-0.35237343
H91G92R-0.34671282
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for S100A7 from PDB

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Differential gene expression and gene-gene network for S100A7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of S100A7 and the right PPI network was created from samples without mutations in the LBS of S100A7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for S100A7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033860Psoriasis11Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for S100A7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB044741-Anilino-8-Naphthalene SulfonateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of S100A7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of S100A7
Multiple alignments for P31151 in multiple species
LBSAA sequence# speciesSpecies


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