mutLBSgeneDB |
Gene summary for S100A7 |
Gene summary |
Basic gene Info. | Gene symbol | S100A7 |
Gene name | S100 calcium binding protein A7 | |
Synonyms | PSOR1|S100A7c | |
Cytomap | UCSC genome browser: 1q21 | |
Type of gene | protein-coding | |
RefGenes | NM_002963.3, | |
Description | S100 calcium-binding protein A7 (psoriasin 1)protein S100-A7psoriasin 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600353 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143556 | ||
HPRD : 02645 | ||
Vega : OTTHUMG00000013123 | ||
Protein | UniProt: P31151 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_S100A7 | |
BioGPS: 6278 | ||
Pathway | NCI Pathway Interaction Database: S100A7 | |
KEGG: S100A7 | ||
REACTOME: S100A7 | ||
Pathway Commons: S100A7 | ||
Context | iHOP: S100A7 | |
ligand binding site mutation search in PubMed: S100A7 | ||
UCL Cancer Institute: S100A7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0000302 | response to reactive oxygen species | 16082188 | GO:0010820 | positive regulation of T cell chemotaxis | 18606705 | GO:0051238 | sequestering of metal ion | 15568027 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18606705 | GO:0071624 | positive regulation of granulocyte chemotaxis | 18606705 | GO:0090026 | positive regulation of monocyte chemotaxis | 18606705 |
Top |
Ligand binding site mutations for S100A7 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D67 | D67N | COAD | 1 | D67,K69 | K68N | COAD | 1 | H91 | G92R | SKCM | 1 | H91 | G92V | SKCM | 1 | H18 | H18N | SKCM | 1 | N65 | N65H | STAD | 1 | H91 | G92R | THCA | 1 | D63 | D63Y | UCEC | 1 | D67,K69 | K68N | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for S100A7 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D67 | D67N | -1.9337704 | K69 | K68N | -1.2633066 | D67 | K68N | -1.2633066 | H18 | H18N | -1.0724492 | N65 | N65H | -0.81213066 | D63 | D63Y | -0.7480611 | H91 | G92V | -0.35237343 | H91 | G92R | -0.34671282 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for S100A7 from PDB |
Top |
Differential gene expression and gene-gene network for S100A7 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for S100A7 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0033860 | Psoriasis | 11 | Biomarker, GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for S100A7 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB04474 | 1-Anilino-8-Naphthalene Sulfonate | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of S100A7 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of S100A7 |
Multiple alignments for P31151 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |