mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for S100A8
Gene summary
Basic gene Info.Gene symbolS100A8
Gene nameS100 calcium binding protein A8
Synonyms60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_002964.4,
DescriptionMRP-8S100 calcium-binding protein A8 (calgranulin A)calgranulin Acalgranulin-Acalprotectin L1L subunitcystic fibrosis antigenleukocyte L1 complex light chainmigration inhibitory factor-related protein 8protein S100-A8urinary stone protein band A
Modification date20141222
dbXrefs MIM : 123885
HGNC : HGNC
Ensembl : ENSG00000143546
HPRD : 00471
Vega : OTTHUMG00000013124
ProteinUniProt: P05109
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100A8
BioGPS: 6279
PathwayNCI Pathway Interaction Database: S100A8
KEGG: S100A8
REACTOME: S100A8
Pathway Commons: S100A8
ContextiHOP: S100A8
ligand binding site mutation search in PubMed: S100A8
UCL Cancer Institute: S100A8
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0002523leukocyte migration involved in inflammatory response12626582
GO:0006914autophagy19935772
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process19935772
GO:0030593neutrophil chemotaxis12626582
GO:0050729positive regulation of inflammatory response12626582
GO:0070488neutrophil aggregation12626582
GO:2001244positive regulation of intrinsic apoptotic signaling pathway19935772


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Ligand binding site mutations for S100A8

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y30,A28V29LLUSC1
E70Q69HUCEC1
S20S20FUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for S100A8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y30V29L-1.1688834
A28V29L-1.1688834
E70Q69H-0.95736929
S20S20F-0.37952948
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for S100A8 from PDB

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Differential gene expression and gene-gene network for S100A8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of S100A8 and the right PPI network was created from samples without mutations in the LBS of S100A8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for S100A8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0011615Dermatitis, Atopic4Biomarker, GeneticVariation
umls:C0023467Leukemia, Myeloid, Acute2Biomarker
umls:C0022548Keloid1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for S100A8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of S100A8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1mr8AE70
CACALCIUM(2+)1mr8BE70
CACALCIUM(2+)1xk4AE70
CACALCIUM(2+)1xk4BE70
CACALCIUM(2+)1xk4EE70
CACALCIUM(2+)1xk4FE70
CACALCIUM(2+)1xk4IE70
CACALCIUM(2+)1xk4JE70
CACALCIUM(2+)4ggfAE70
CACALCIUM(2+)4ggfKE70
CACALCIUM(2+)4ggfSE70
CACALCIUM(2+)4ggfUE70
CACALCIUM(2+)4xjkAE70
CACALCIUM(2+)4xjkCE70
CACALCIUM(2+)4xjkEE70
CACALCIUM(2+)4xjkGE70
CACALCIUM(2+)4xjkIE70
CACALCIUM(2+)1mr8AS20 A28 Y30
CACALCIUM(2+)1mr8BS20 A28 Y30
CACALCIUM(2+)1xk4AS20 A28 Y30
CACALCIUM(2+)1xk4BS20 A28 Y30
CACALCIUM(2+)1xk4ES20 A28 Y30
CACALCIUM(2+)1xk4FS20 A28 Y30
CACALCIUM(2+)1xk4IS20 A28 Y30
CACALCIUM(2+)1xk4JS20 A28 Y30


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Conservation information for LBS of S100A8
Multiple alignments for P05109 in multiple species
LBSAA sequence# speciesSpecies
A28KGNFHAVYRDD1Homo sapiens
A28QGNHHALYKND1Mus musculus
A28KGNHHALYRDD1Rattus norvegicus
A28KGNYHAVYRDD1Bos taurus
A65INTDGAVNFQE1Homo sapiens
A65INSDNAINFEE1Mus musculus
A65VNSDNAINFEE1Rattus norvegicus
A65INQDGGINFEE1Bos taurus
D59WFKELDINTDG1Homo sapiens
D59LFRELDINSDN1Mus musculus
D59LFKELDVNSDN1Rattus norvegicus
D59WFKELDINQDG1Bos taurus
D63LDINTDGAVNF1Homo sapiens
D63LDINSDNAINF1Mus musculus
D63LDVNSDNAINF1Rattus norvegicus
D63LDINQDGGINF1Bos taurus
E70AVNFQEFLILV1Homo sapiens
E70AINFEEFLAMV1Mus musculus
E70AINFEEFLVLV1Rattus norvegicus
E70GINFEEFLVLV1Bos taurus
F26LIKGNFHAVYR1Homo sapiens
F26NIQGNHHALYK1Mus musculus
F26GIKGNHHALYR1Rattus norvegicus
F26LKKGNYHAVYR1Bos taurus
H17IIDVYHKYSLI1Homo sapiens
H17LIDVYHNYSNI1Mus musculus
H17VIEVYHNYSGI1Rattus norvegicus
H17LIDVYHKYSLK1Bos taurus
H27IKGNFHAVYRD1Homo sapiens
H27IQGNHHALYKN1Mus musculus
H27IKGNHHALYRD1Rattus norvegicus
H27KKGNYHAVYRD1Bos taurus
K23KYSLIKGNFHA1Homo sapiens
K23NYSNIQGNHHA1Mus musculus
K23NYSGIKGNHHA1Rattus norvegicus
K23KYSLKKGNYHA1Bos taurus
N25SLIKGNFHAVY1Homo sapiens
N25SNIQGNHHALY1Mus musculus
N25SGIKGNHHALY1Rattus norvegicus
N25SLKKGNYHAVY1Bos taurus
N61KELDINTDGAV1Homo sapiens
N61RELDINSDNAI1Mus musculus
N61KELDVNSDNAI1Rattus norvegicus
N61KELDINQDGGI1Bos taurus
S20VYHKYSLIKGN1Homo sapiens
S20VYHNYSNIQGN1Mus musculus
S20VYHNYSGIKGN1Rattus norvegicus
S20VYHKYSLKKGN1Bos taurus
Y30NFHAVYRDDLK1Homo sapiens
Y30NHHALYKNDFK1Mus musculus
Y30NHHALYRDDFR1Rattus norvegicus
Y30NYHAVYRDDLK1Bos taurus


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