mutLBSgeneDB |
Gene summary for S100A9 |
Gene summary |
Basic gene Info. | Gene symbol | S100A9 |
Gene name | S100 calcium binding protein A9 | |
Synonyms | 60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14 | |
Cytomap | UCSC genome browser: 1q21 | |
Type of gene | protein-coding | |
RefGenes | NM_002965.3, | |
Description | MRP-14S100 calcium-binding protein A9 (calgranulin B)calgranulin Bcalgranulin-Bcalprotectin L1H subunitleukocyte L1 complex heavy chainmigration inhibitory factor-related protein 14protein S100-A9 | |
Modification date | 20141222 | |
dbXrefs | MIM : 123886 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163220 | ||
HPRD : 00472 | ||
Vega : OTTHUMG00000013125 | ||
Protein | UniProt: P06702 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_S100A9 | |
BioGPS: 6280 | ||
Pathway | NCI Pathway Interaction Database: S100A9 | |
KEGG: S100A9 | ||
REACTOME: S100A9 | ||
Pathway Commons: S100A9 | ||
Context | iHOP: S100A9 | |
ligand binding site mutation search in PubMed: S100A9 | ||
UCL Cancer Institute: S100A9 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0002523 | leukocyte migration involved in inflammatory response | 12626582 | GO:0006914 | autophagy | 19935772 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 19935772 | GO:0030593 | neutrophil chemotaxis | 12626582 | GO:0050729 | positive regulation of inflammatory response | 12626582 | GO:0070488 | neutrophil aggregation | 12626582 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 19935772 |
Top |
Ligand binding site mutations for S100A9 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | L8 | S6L | COAD | 2 | D71 | D71N | BLCA | 1 | R85 | A84V | COAD | 1 | D65 | D65G | COAD | 1 | E36 | E36K | SKCM | 1 | E78 | E78V | SKCM | 1 | E36 | G35E | SKCM | 1 | H91 | S90F | SKCM | 1 | H61 | E60K | SKCM | 1 | R85 | T87P | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for S100A9 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L8 | S6L | 0.33117844 | D71 | D71N | -1.2970929 | H61 | E60K | -1.140684 | D65 | D65G | -1.1261212 | E36 | E36K | -1.0318246 | R85 | T87P | -0.8637651 | E78 | E78V | -0.7796702 | H91 | S90F | -0.67208943 | E36 | G35E | -0.58432806 | R85 | A84V | -0.003598752 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for S100A9 from PDB |
PDB ID | PDB title | PDB structure | 1XK4 | Crystal structure of human calprotectin(S100A8/S100A9) |
Top |
Differential gene expression and gene-gene network for S100A9 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for S100A9 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0009375 | Colonic Neoplasms | 1 | Biomarker |
umls:C0022548 | Keloid | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for S100A9 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of S100A9 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1irj | A | D71 E78 | CA | CALCIUM(2+) | 1irj | B | D71 E78 | CA | CALCIUM(2+) | 1irj | C | D71 E78 | CA | CALCIUM(2+) | 1irj | D | D71 E78 | CA | CALCIUM(2+) | 1irj | E | D71 E78 | CA | CALCIUM(2+) | 1irj | F | D71 E78 | CA | CALCIUM(2+) | 1irj | G | D71 E78 | CA | CALCIUM(2+) | 1irj | H | D71 E78 | CA | CALCIUM(2+) | 1xk4 | C | D71 E78 | CA | CALCIUM(2+) | 1xk4 | D | D71 E78 | CA | CALCIUM(2+) | 1xk4 | G | D71 E78 | CA | CALCIUM(2+) | 1xk4 | H | D71 E78 | CA | CALCIUM(2+) | 1xk4 | K | D71 E78 | CA | CALCIUM(2+) | 1xk4 | L | D71 E78 | CA | CALCIUM(2+) | 4ggf | C | D71 E78 | CA | CALCIUM(2+) | 4ggf | L | D71 E78 | CA | CALCIUM(2+) | 4ggf | T | D71 E78 | CA | CALCIUM(2+) | 4ggf | V | D71 E78 | CA | CALCIUM(2+) | 4xjk | B | D71 E78 | CA | CALCIUM(2+) | 4xjk | D | D71 E78 | CA | CALCIUM(2+) | 4xjk | F | D71 E78 | CA | CALCIUM(2+) | 4xjk | H | D71 E78 | CA | CALCIUM(2+) | 4xjk | J | D71 E78 | CA | CALCIUM(2+) | 1irj | A | E36 | CA | CALCIUM(2+) | 1irj | B | E36 | CA | CALCIUM(2+) | 1irj | C | E36 | CA | CALCIUM(2+) | 1irj | D | E36 | CA | CALCIUM(2+) | 1irj | E | E36 | CA | CALCIUM(2+) | 1irj | F | E36 | CA | CALCIUM(2+) | 1irj | G | E36 | CA | CALCIUM(2+) | 1irj | H | E36 | CA | CALCIUM(2+) | 1xk4 | C | E36 | CA | CALCIUM(2+) | 1xk4 | D | E36 | CA | CALCIUM(2+) | 1xk4 | G | E36 | CA | CALCIUM(2+) | 1xk4 | H | E36 | CA | CALCIUM(2+) | 1xk4 | K | E36 | CA | CALCIUM(2+) | 1xk4 | L | E36 | CA | CALCIUM(2+) | 4ggf | C | E36 | CA | CALCIUM(2+) | 4ggf | L | E36 | CA | CALCIUM(2+) | 4ggf | T | E36 | CA | CALCIUM(2+) | 4ggf | V | E36 | CPS | CHAPS | 1irj | B | H61 D65 | CPS | CHAPS | 1irj | G | H61 D65 | CPS | CHAPS | 1irj | D | H61 D65 R85 | MN | MANGANESE(2+) | 4ggf | C | H91 | MN | MANGANESE(2+) | 4ggf | L | H91 | MN | MANGANESE(2+) | 4ggf | T | H91 | MN | MANGANESE(2+) | 4ggf | V | H91 | MN | MANGANESE(2+) | 4xjk | B | H91 | MN | MANGANESE(2+) | 4xjk | D | H91 | MN | MANGANESE(2+) | 4xjk | F | H91 | MN | MANGANESE(2+) | 4xjk | H | H91 | MN | MANGANESE(2+) | 4xjk | J | H91 |
Top |
Conservation information for LBS of S100A9 |
Multiple alignments for P06702 in multiple species |
LBS | AA sequence | # species | Species | D30 | KLGHPDTLNQG | 1 | Homo sapiens | D30 | KEGHPDTLSKK | 1 | Mus musculus | D30 | KYGHPDTLNKA | 1 | Rattus norvegicus | D30 | RLGHYDTLIQK | 1 | Bos taurus | D65 | EHIMEDLDTNA | 1 | Homo sapiens | D65 | NDIMEDLDTNQ | 1 | Mus musculus | D65 | RDIMEDLDTNQ | 1 | Rattus norvegicus | D65 | NEIMEDLDTNV | 1 | Bos taurus | D67 | IMEDLDTNQDN | 2 | Mus musculus, Rattus norvegicus | D67 | IMEDLDTNADK | 1 | Homo sapiens | D67 | IMEDLDTNVDK | 1 | Bos taurus | D71 | LDTNQDNQLSF | 2 | Mus musculus, Rattus norvegicus | D71 | LDTNADKQLSF | 1 | Homo sapiens | D71 | LDTNVDKQLSF | 1 | Bos taurus | E36 | TLNQGEFKELV | 1 | Homo sapiens | E36 | TLSKKEFRQMV | 1 | Mus musculus | E36 | TLNKAEFKEMV | 1 | Rattus norvegicus | E36 | TLIQKEFKQLV | 1 | Bos taurus | E52 | NFLKKENKNEK | 1 | Homo sapiens | E52 | TFMKKEKRNEA | 1 | Mus musculus | E52 | NFLKREKRNEN | 1 | Rattus norvegicus | E52 | NFLKKQKKNEA | 1 | Bos taurus | E78 | QLSFEECMMLM | 2 | Mus musculus, Rattus norvegicus | E78 | QLSFEEFIMLM | 1 | Homo sapiens | E78 | QLSFEEFIMLV | 1 | Bos taurus | F48 | KDLQNFLKKEN | 1 | Homo sapiens | F48 | AQLATFMKKEK | 1 | Mus musculus | F48 | KDLPNFLKREK | 1 | Rattus norvegicus | F48 | KELPNFLKKQK | 1 | Bos taurus | G27 | YSVKLGHPDTL | 1 | Homo sapiens | G27 | YSRKEGHPDTL | 1 | Mus musculus | G27 | YSRKYGHPDTL | 1 | Rattus norvegicus | G27 | YSVRLGHYDTL | 1 | Bos taurus | H103 | -EGPGHHHKPG | 1 | Homo sapiens | H103 | PRGHGHSHGKG | 1 | Mus musculus | H103 | PRGHDHSHGKG | 1 | Rattus norvegicus | H103 | PPGQGHRHGPG | 1 | Bos taurus | H105 | GPGHHHKPGLG | 1 | Homo sapiens | H105 | GHGHSHGKGCG | 1 | Mus musculus | H105 | GHDHSHGKGCG | 1 | Rattus norvegicus | H105 | GQGHRHGPGYG | 1 | Bos taurus | H20 | IINTFHQYSVK | 1 | Homo sapiens | H20 | IIDTFHQYSRK | 1 | Mus musculus | H20 | IINVFHQYSRK | 1 | Rattus norvegicus | H20 | IINIFHQYSVR | 1 | Bos taurus | H28 | SVKLGHPDTLN | 1 | Homo sapiens | H28 | SRKEGHPDTLS | 1 | Mus musculus | H28 | SRKYGHPDTLN | 1 | Rattus norvegicus | H28 | SVRLGHYDTLI | 1 | Bos taurus | H61 | EKVIEHIMEDL | 1 | Homo sapiens | H61 | EALINDIMEDL | 1 | Mus musculus | H61 | ENLLRDIMEDL | 1 | Rattus norvegicus | H61 | EAAINEIMEDL | 1 | Bos taurus | H91 | LIFACHEKLHE | 2 | Mus musculus, Rattus norvegicus | H91 | LTWASHEKMHE | 1 | Homo sapiens | H91 | LTVASHEEMHN | 1 | Bos taurus | H95 | CHEKLHENNPR | 2 | Mus musculus, Rattus norvegicus | H95 | SHEKMHEGD-E | 1 | Homo sapiens | H95 | SHEEMHNTAPP | 1 | Bos taurus | I62 | KVIEHIMEDLD | 1 | Homo sapiens | I62 | ALINDIMEDLD | 1 | Mus musculus | I62 | NLLRDIMEDLD | 1 | Rattus norvegicus | I62 | AAINEIMEDLD | 1 | Bos taurus | L26 | QYSVKLGHPDT | 1 | Homo sapiens | L26 | QYSRKEGHPDT | 1 | Mus musculus | L26 | QYSRKYGHPDT | 1 | Rattus norvegicus | L26 | QYSVRLGHYDT | 1 | Bos taurus | L32 | GHPDTLNQGEF | 1 | Homo sapiens | L32 | GHPDTLSKKEF | 1 | Mus musculus | L32 | GHPDTLNKAEF | 1 | Rattus norvegicus | L32 | GHYDTLIQKEF | 1 | Bos taurus | L8 | KM-SQLERNIE | 1 | Homo sapiens | L8 | KAPSQMERSIT | 1 | Mus musculus | L8 | KTGSQLERSIS | 1 | Rattus norvegicus | L8 | KM-SQMESSIE | 1 | Bos taurus | N69 | EDLDTNQDNQL | 2 | Mus musculus, Rattus norvegicus | N69 | EDLDTNADKQL | 1 | Homo sapiens | N69 | EDLDTNVDKQL | 1 | Bos taurus | Q73 | TNQDNQLSFEE | 2 | Mus musculus, Rattus norvegicus | Q73 | TNADKQLSFEE | 1 | Homo sapiens | Q73 | TNVDKQLSFEE | 1 | Bos taurus | R85 | IMLMARLTWAS | 1 | Homo sapiens | R85 | MMLMAKLIFAC | 1 | Mus musculus | R85 | MMLMGKLIFAC | 1 | Rattus norvegicus | R85 | IMLVARLTVAS | 1 | Bos taurus | S23 | TFHQYSVKLGH | 1 | Homo sapiens | S23 | TFHQYSRKEGH | 1 | Mus musculus | S23 | VFHQYSRKYGH | 1 | Rattus norvegicus | S23 | IFHQYSVRLGH | 1 | Bos taurus | T31 | LGHPDTLNQGE | 1 | Homo sapiens | T31 | EGHPDTLSKKE | 1 | Mus musculus | T31 | YGHPDTLNKAE | 1 | Rattus norvegicus | T31 | LGHYDTLIQKE | 1 | Bos taurus | V58 | NKNEKVIEHIM | 1 | Homo sapiens | V58 | KRNEALINDIM | 1 | Mus musculus | V58 | KRNENLLRDIM | 1 | Rattus norvegicus | V58 | KKNEAAINEIM | 1 | Bos taurus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |