mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for S100A9
Gene summary
Basic gene Info.Gene symbolS100A9
Gene nameS100 calcium binding protein A9
Synonyms60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_002965.3,
DescriptionMRP-14S100 calcium-binding protein A9 (calgranulin B)calgranulin Bcalgranulin-Bcalprotectin L1H subunitleukocyte L1 complex heavy chainmigration inhibitory factor-related protein 14protein S100-A9
Modification date20141222
dbXrefs MIM : 123886
HGNC : HGNC
Ensembl : ENSG00000163220
HPRD : 00472
Vega : OTTHUMG00000013125
ProteinUniProt: P06702
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100A9
BioGPS: 6280
PathwayNCI Pathway Interaction Database: S100A9
KEGG: S100A9
REACTOME: S100A9
Pathway Commons: S100A9
ContextiHOP: S100A9
ligand binding site mutation search in PubMed: S100A9
UCL Cancer Institute: S100A9
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0002523leukocyte migration involved in inflammatory response12626582
GO:0006914autophagy19935772
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process19935772
GO:0030593neutrophil chemotaxis12626582
GO:0050729positive regulation of inflammatory response12626582
GO:0070488neutrophil aggregation12626582
GO:2001244positive regulation of intrinsic apoptotic signaling pathway19935772


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Ligand binding site mutations for S100A9

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L8S6LCOAD2
D71D71NBLCA1
R85A84VCOAD1
D65D65GCOAD1
E36E36KSKCM1
E78E78VSKCM1
E36G35ESKCM1
H91S90FSKCM1
H61E60KSKCM1
R85T87PSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for S100A9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L8S6L0.33117844
D71D71N-1.2970929
H61E60K-1.140684
D65D65G-1.1261212
E36E36K-1.0318246
R85T87P-0.8637651
E78E78V-0.7796702
H91S90F-0.67208943
E36G35E-0.58432806
R85A84V-0.003598752
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for S100A9 from PDB
PDB IDPDB titlePDB structure
1XK4Crystal structure of human calprotectin(S100A8/S100A9)

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Differential gene expression and gene-gene network for S100A9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of S100A9 and the right PPI network was created from samples without mutations in the LBS of S100A9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for S100A9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0009375Colonic Neoplasms1Biomarker
umls:C0022548Keloid1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for S100A9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of S100A9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1irjAD71 E78
CACALCIUM(2+)1irjBD71 E78
CACALCIUM(2+)1irjCD71 E78
CACALCIUM(2+)1irjDD71 E78
CACALCIUM(2+)1irjED71 E78
CACALCIUM(2+)1irjFD71 E78
CACALCIUM(2+)1irjGD71 E78
CACALCIUM(2+)1irjHD71 E78
CACALCIUM(2+)1xk4CD71 E78
CACALCIUM(2+)1xk4DD71 E78
CACALCIUM(2+)1xk4GD71 E78
CACALCIUM(2+)1xk4HD71 E78
CACALCIUM(2+)1xk4KD71 E78
CACALCIUM(2+)1xk4LD71 E78
CACALCIUM(2+)4ggfCD71 E78
CACALCIUM(2+)4ggfLD71 E78
CACALCIUM(2+)4ggfTD71 E78
CACALCIUM(2+)4ggfVD71 E78
CACALCIUM(2+)4xjkBD71 E78
CACALCIUM(2+)4xjkDD71 E78
CACALCIUM(2+)4xjkFD71 E78
CACALCIUM(2+)4xjkHD71 E78
CACALCIUM(2+)4xjkJD71 E78
CACALCIUM(2+)1irjAE36
CACALCIUM(2+)1irjBE36
CACALCIUM(2+)1irjCE36
CACALCIUM(2+)1irjDE36
CACALCIUM(2+)1irjEE36
CACALCIUM(2+)1irjFE36
CACALCIUM(2+)1irjGE36
CACALCIUM(2+)1irjHE36
CACALCIUM(2+)1xk4CE36
CACALCIUM(2+)1xk4DE36
CACALCIUM(2+)1xk4GE36
CACALCIUM(2+)1xk4HE36
CACALCIUM(2+)1xk4KE36
CACALCIUM(2+)1xk4LE36
CACALCIUM(2+)4ggfCE36
CACALCIUM(2+)4ggfLE36
CACALCIUM(2+)4ggfTE36
CACALCIUM(2+)4ggfVE36
CPSCHAPS1irjBH61 D65
CPSCHAPS1irjGH61 D65
CPSCHAPS1irjDH61 D65 R85
MNMANGANESE(2+)4ggfCH91
MNMANGANESE(2+)4ggfLH91
MNMANGANESE(2+)4ggfTH91
MNMANGANESE(2+)4ggfVH91
MNMANGANESE(2+)4xjkBH91
MNMANGANESE(2+)4xjkDH91
MNMANGANESE(2+)4xjkFH91
MNMANGANESE(2+)4xjkHH91
MNMANGANESE(2+)4xjkJH91


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Conservation information for LBS of S100A9
Multiple alignments for P06702 in multiple species
LBSAA sequence# speciesSpecies
D30KLGHPDTLNQG1Homo sapiens
D30KEGHPDTLSKK1Mus musculus
D30KYGHPDTLNKA1Rattus norvegicus
D30RLGHYDTLIQK1Bos taurus
D65EHIMEDLDTNA1Homo sapiens
D65NDIMEDLDTNQ1Mus musculus
D65RDIMEDLDTNQ1Rattus norvegicus
D65NEIMEDLDTNV1Bos taurus
D67IMEDLDTNQDN2Mus musculus, Rattus norvegicus
D67IMEDLDTNADK1Homo sapiens
D67IMEDLDTNVDK1Bos taurus
D71LDTNQDNQLSF2Mus musculus, Rattus norvegicus
D71LDTNADKQLSF1Homo sapiens
D71LDTNVDKQLSF1Bos taurus
E36TLNQGEFKELV1Homo sapiens
E36TLSKKEFRQMV1Mus musculus
E36TLNKAEFKEMV1Rattus norvegicus
E36TLIQKEFKQLV1Bos taurus
E52NFLKKENKNEK1Homo sapiens
E52TFMKKEKRNEA1Mus musculus
E52NFLKREKRNEN1Rattus norvegicus
E52NFLKKQKKNEA1Bos taurus
E78QLSFEECMMLM2Mus musculus, Rattus norvegicus
E78QLSFEEFIMLM1Homo sapiens
E78QLSFEEFIMLV1Bos taurus
F48KDLQNFLKKEN1Homo sapiens
F48AQLATFMKKEK1Mus musculus
F48KDLPNFLKREK1Rattus norvegicus
F48KELPNFLKKQK1Bos taurus
G27YSVKLGHPDTL1Homo sapiens
G27YSRKEGHPDTL1Mus musculus
G27YSRKYGHPDTL1Rattus norvegicus
G27YSVRLGHYDTL1Bos taurus
H103-EGPGHHHKPG1Homo sapiens
H103PRGHGHSHGKG1Mus musculus
H103PRGHDHSHGKG1Rattus norvegicus
H103PPGQGHRHGPG1Bos taurus
H105GPGHHHKPGLG1Homo sapiens
H105GHGHSHGKGCG1Mus musculus
H105GHDHSHGKGCG1Rattus norvegicus
H105GQGHRHGPGYG1Bos taurus
H20IINTFHQYSVK1Homo sapiens
H20IIDTFHQYSRK1Mus musculus
H20IINVFHQYSRK1Rattus norvegicus
H20IINIFHQYSVR1Bos taurus
H28SVKLGHPDTLN1Homo sapiens
H28SRKEGHPDTLS1Mus musculus
H28SRKYGHPDTLN1Rattus norvegicus
H28SVRLGHYDTLI1Bos taurus
H61EKVIEHIMEDL1Homo sapiens
H61EALINDIMEDL1Mus musculus
H61ENLLRDIMEDL1Rattus norvegicus
H61EAAINEIMEDL1Bos taurus
H91LIFACHEKLHE2Mus musculus, Rattus norvegicus
H91LTWASHEKMHE1Homo sapiens
H91LTVASHEEMHN1Bos taurus
H95CHEKLHENNPR2Mus musculus, Rattus norvegicus
H95SHEKMHEGD-E1Homo sapiens
H95SHEEMHNTAPP1Bos taurus
I62KVIEHIMEDLD1Homo sapiens
I62ALINDIMEDLD1Mus musculus
I62NLLRDIMEDLD1Rattus norvegicus
I62AAINEIMEDLD1Bos taurus
L26QYSVKLGHPDT1Homo sapiens
L26QYSRKEGHPDT1Mus musculus
L26QYSRKYGHPDT1Rattus norvegicus
L26QYSVRLGHYDT1Bos taurus
L32GHPDTLNQGEF1Homo sapiens
L32GHPDTLSKKEF1Mus musculus
L32GHPDTLNKAEF1Rattus norvegicus
L32GHYDTLIQKEF1Bos taurus
L8KM-SQLERNIE1Homo sapiens
L8KAPSQMERSIT1Mus musculus
L8KTGSQLERSIS1Rattus norvegicus
L8KM-SQMESSIE1Bos taurus
N69EDLDTNQDNQL2Mus musculus, Rattus norvegicus
N69EDLDTNADKQL1Homo sapiens
N69EDLDTNVDKQL1Bos taurus
Q73TNQDNQLSFEE2Mus musculus, Rattus norvegicus
Q73TNADKQLSFEE1Homo sapiens
Q73TNVDKQLSFEE1Bos taurus
R85IMLMARLTWAS1Homo sapiens
R85MMLMAKLIFAC1Mus musculus
R85MMLMGKLIFAC1Rattus norvegicus
R85IMLVARLTVAS1Bos taurus
S23TFHQYSVKLGH1Homo sapiens
S23TFHQYSRKEGH1Mus musculus
S23VFHQYSRKYGH1Rattus norvegicus
S23IFHQYSVRLGH1Bos taurus
T31LGHPDTLNQGE1Homo sapiens
T31EGHPDTLSKKE1Mus musculus
T31YGHPDTLNKAE1Rattus norvegicus
T31LGHYDTLIQKE1Bos taurus
V58NKNEKVIEHIM1Homo sapiens
V58KRNEALINDIM1Mus musculus
V58KRNENLLRDIM1Rattus norvegicus
V58KKNEAAINEIM1Bos taurus


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