mutLBSgeneDB |
Gene summary for SATB1 |
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Basic gene Info. | Gene symbol | SATB1 |
Gene name | SATB homeobox 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3p23 | |
Type of gene | protein-coding | |
RefGenes | NM_001131010.2, NM_001195470.1,NM_002971.4, | |
Description | DNA-binding protein SATB1special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)special AT-rich sequence-binding protein 1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 602075 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182568 | ||
HPRD : 03647 | ||
Vega : OTTHUMG00000129890 | ||
Protein | UniProt: Q01826 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SATB1 | |
BioGPS: 6304 | ||
Pathway | NCI Pathway Interaction Database: SATB1 | |
KEGG: SATB1 | ||
REACTOME: SATB1 | ||
Pathway Commons: SATB1 | ||
Context | iHOP: SATB1 | |
ligand binding site mutation search in PubMed: SATB1 | ||
UCL Cancer Institute: SATB1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for SATB1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | R410 | R410Q | OV | 1 | R410 | R410Q | STAD | 1 | R400 | R400I | UCEC | 1 | S421 | S421Y | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SATB1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R410 | R410Q | -1.2741109 | S421 | S421Y | -0.19797458 | R400 | R400I | -0.09056908 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for SATB1 |
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Phenotype information for SATB1 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SATB1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2o49 | A | R400 S421 | NUC | Nucleic Acids | 2o4a | A | R400 S421 | NUC | Nucleic Acids | 2o4a | A | R410 |
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Conservation information for LBS of SATB1 |
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LBS | AA sequence | # species | Species |
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