mutLBSgeneDB |
Gene summary for CCL13 |
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Basic gene Info. | Gene symbol | CCL13 |
Gene name | chemokine (C-C motif) ligand 13 | |
Synonyms | CKb10|MCP-4|NCC-1|NCC1|SCYA13|SCYL1 | |
Cytomap | UCSC genome browser: 17q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_005408.2, | |
Description | C-C motif chemokine 13CK-beta-10monocyte chemoattractant protein 4monocyte chemotactic protein 4new CC chemokine 1small inducible cytokine subfamily A (Cys-Cys), member 13small-inducible cytokine A13 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601391 | |
HGNC : HGNC | ||
Ensembl : ENSG00000181374 | ||
HPRD : 03230 | ||
Vega : OTTHUMG00000132890 | ||
Protein | UniProt: Q99616 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCL13 | |
BioGPS: 6357 | ||
Pathway | NCI Pathway Interaction Database: CCL13 | |
KEGG: CCL13 | ||
REACTOME: CCL13 | ||
Pathway Commons: CCL13 | ||
Context | iHOP: CCL13 | |
ligand binding site mutation search in PubMed: CCL13 | ||
UCL Cancer Institute: CCL13 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0007010 | cytoskeleton organization | 10072545 | GO:0008360 | regulation of cell shape | 10072545 | GO:0048245 | eosinophil chemotaxis | 10072545 |
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Ligand binding site mutations for CCL13 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | T67 | T67N | BRCA | 1 | K68 | K68N | GBM | 1 | K71 | E72D | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CCL13 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K68 | K68N | -0.94516778 | K71 | E72D | -0.63957744 | T67 | T67N | -0.52822459 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CCL13 |
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Phenotype information for CCL13 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CCL13 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CCL13 |
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LBS | AA sequence | # species | Species | K68 | VIFRTKLGKEI | 1 | Homo sapiens | K68 | VVFVTKLKREV | 1 | Mus musculus | K68 | VVFVTKLKREI | 1 | Rattus norvegicus | K71 | RTKLGKEICAD | 1 | Homo sapiens | K71 | VTKLKREVCAD | 1 | Mus musculus | K71 | VTKLKREICAD | 1 | Rattus norvegicus | L69 | IFRTKLGKEIC | 1 | Homo sapiens | L69 | VFVTKLKREVC | 1 | Mus musculus | L69 | VFVTKLKREIC | 1 | Rattus norvegicus | R47 | KISLQRLKSYV | 1 | Homo sapiens | R47 | MIPMSRLESYK | 1 | Mus musculus | R47 | MIPMSRLENYK | 1 | Rattus norvegicus | T67 | AVVFVTKLKRE | 2 | Mus musculus, Rattus norvegicus | T67 | AVIFRTKLGKE | 1 | Homo sapiens |
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