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mutLBSgeneDB |
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| Gene summary for MRPL17 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL17 |
| Gene name | mitochondrial ribosomal protein L17 | |
| Synonyms | L17mt|LIP2|MRP-L17|MRP-L26|RPL17L|RPML26 | |
| Cytomap | UCSC genome browser: 11p15.5-p15.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022061.3, | |
| Description | 39S ribosomal protein L17, mitochondrialLYST-interacting protein 2LYST-interacting protein LIP2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611830 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000158042 | ||
| HPRD : 10096 | ||
| Vega : OTTHUMG00000165505 | ||
| Protein | UniProt: Q9NRX2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL17 | |
| BioGPS: 63875 | ||
| Pathway | NCI Pathway Interaction Database: MRPL17 | |
| KEGG: MRPL17 | ||
| REACTOME: MRPL17 | ||
| Pathway Commons: MRPL17 | ||
| Context | iHOP: MRPL17 | |
| ligand binding site mutation search in PubMed: MRPL17 | ||
| UCL Cancer Institute: MRPL17 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL17 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V14 | V14I | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL17 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V14 | V14I | -0.2521618 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL17 from PDB |
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| Differential gene expression and gene-gene network for MRPL17 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL17 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL17 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL17 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | O | V14 |
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| Conservation information for LBS of MRPL17 |
| Multiple alignments for Q9NRX2 in multiple species |
| LBS | AA sequence | # species | Species | A118 | S-LDRAKMAVI | 1 | Homo sapiens | A118 | KEQDRAKMAVI | 1 | Mus musculus | A118 | NQQDRAKMAVI | 1 | Bos taurus | A47 | IEAPWARVDEM | 1 | Homo sapiens | A47 | IEATWARADEM | 1 | Mus musculus | A47 | IEASWARVDEL | 1 | Bos taurus | D116 | NRS-LDRAKMA | 1 | Homo sapiens | D116 | NRKEQDRAKMA | 1 | Mus musculus | D116 | NRNQQDRAKMA | 1 | Bos taurus | E43 | RHERIEAPWAR | 1 | Homo sapiens | E43 | RHERIEATWAR | 1 | Mus musculus | E43 | RHERIEASWAR | 1 | Bos taurus | E82 | DFWLTEKDLIP | 3 | Homo sapiens, Mus musculus, Bos taurus | G12 | AAISHGRVYRR | 2 | Mus musculus, Bos taurus | G12 | AAISHGRVFRR | 1 | Homo sapiens | G21 | RRLGLGPESRI | 2 | Mus musculus, Bos taurus | G21 | RRMGLGPESRI | 1 | Homo sapiens | G35 | RNLLTGLVRHE | 2 | Homo sapiens, Mus musculus | G35 | QNLLTGLVRHE | 1 | Bos taurus | H11 | AAAISHGRVYR | 2 | Mus musculus, Bos taurus | H11 | AAAISHGRVFR | 1 | Homo sapiens | H27 | PESRIHLLRNL | 2 | Homo sapiens, Mus musculus | H27 | PESRIHLLQNL | 1 | Bos taurus | H39 | TGLVRHERIEA | 3 | Homo sapiens, Mus musculus, Bos taurus | I42 | VRHERIEAPWA | 1 | Homo sapiens | I42 | VRHERIEATWA | 1 | Mus musculus | I42 | VRHERIEASWA | 1 | Bos taurus | I9 | SVAAAISHGRV | 1 | Homo sapiens | I9 | SLAAAISHGRV | 1 | Mus musculus | I9 | SFAAAISHGRV | 1 | Bos taurus | K119 | -LDRAKMAVIE | 1 | Homo sapiens | K119 | EQDRAKMAVIE | 1 | Mus musculus | K119 | QQDRAKMAVIE | 1 | Bos taurus | L115 | PNRS-LDRAKM | 1 | Homo sapiens | L115 | PNRKEQDRAKM | 1 | Mus musculus | L115 | PNRNQQDRAKM | 1 | Bos taurus | L20 | YRRLGLGPESR | 2 | Mus musculus, Bos taurus | L20 | FRRMGLGPESR | 1 | Homo sapiens | L32 | HLLRNLLTGLV | 2 | Homo sapiens, Mus musculus | L32 | HLLQNLLTGLV | 1 | Bos taurus | N31 | IHLLRNLLTGL | 2 | Homo sapiens, Mus musculus | N31 | IHLLQNLLTGL | 1 | Bos taurus | P22 | RLGLGPESRIH | 2 | Mus musculus, Bos taurus | P22 | RMGLGPESRIH | 1 | Homo sapiens | R117 | RS-LDRAKMAV | 1 | Homo sapiens | R117 | RKEQDRAKMAV | 1 | Mus musculus | R117 | RNQQDRAKMAV | 1 | Bos taurus | R13 | AISHGRVYRRL | 2 | Mus musculus, Bos taurus | R13 | AISHGRVFRRM | 1 | Homo sapiens | R16 | HGRVYRRLGLG | 2 | Mus musculus, Bos taurus | R16 | HGRVFRRMGLG | 1 | Homo sapiens | R17 | GRVYRRLGLGP | 2 | Mus musculus, Bos taurus | R17 | GRVFRRMGLGP | 1 | Homo sapiens | R48 | EAPWARVDEMR | 1 | Homo sapiens | R48 | EATWARADEMR | 1 | Mus musculus | R48 | EASWARVDELR | 1 | Bos taurus | S10 | VAAAISHGRVF | 1 | Homo sapiens | S10 | LAAAISHGRVY | 1 | Mus musculus | S10 | FAAAISHGRVY | 1 | Bos taurus | T81 | ADFWLTEKDLI | 3 | Homo sapiens, Mus musculus, Bos taurus | V14 | ISHGRVYRRLG | 2 | Mus musculus, Bos taurus | V14 | ISHGRVFRRMG | 1 | Homo sapiens |
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