mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL17
Gene summary
Basic gene Info.Gene symbolMRPL17
Gene namemitochondrial ribosomal protein L17
SynonymsL17mt|LIP2|MRP-L17|MRP-L26|RPL17L|RPML26
CytomapUCSC genome browser: 11p15.5-p15.4
Type of geneprotein-coding
RefGenesNM_022061.3,
Description39S ribosomal protein L17, mitochondrialLYST-interacting protein 2LYST-interacting protein LIP2
Modification date20141207
dbXrefs MIM : 611830
HGNC : HGNC
Ensembl : ENSG00000158042
HPRD : 10096
Vega : OTTHUMG00000165505
ProteinUniProt: Q9NRX2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL17
BioGPS: 63875
PathwayNCI Pathway Interaction Database: MRPL17
KEGG: MRPL17
REACTOME: MRPL17
Pathway Commons: MRPL17
ContextiHOP: MRPL17
ligand binding site mutation search in PubMed: MRPL17
UCL Cancer Institute: MRPL17
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL17

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V14V14IHNSC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL17
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V14V14I-0.2521618
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL17 from PDB

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Differential gene expression and gene-gene network for MRPL17
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL17 and the right PPI network was created from samples without mutations in the LBS of MRPL17. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL17
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL17
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL17 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yOV14


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Conservation information for LBS of MRPL17
Multiple alignments for Q9NRX2 in multiple species
LBSAA sequence# speciesSpecies
A118S-LDRAKMAVI1Homo sapiens
A118KEQDRAKMAVI1Mus musculus
A118NQQDRAKMAVI1Bos taurus
A47IEAPWARVDEM1Homo sapiens
A47IEATWARADEM1Mus musculus
A47IEASWARVDEL1Bos taurus
D116NRS-LDRAKMA1Homo sapiens
D116NRKEQDRAKMA1Mus musculus
D116NRNQQDRAKMA1Bos taurus
E43RHERIEAPWAR1Homo sapiens
E43RHERIEATWAR1Mus musculus
E43RHERIEASWAR1Bos taurus
E82DFWLTEKDLIP3Homo sapiens, Mus musculus, Bos taurus
G12AAISHGRVYRR2Mus musculus, Bos taurus
G12AAISHGRVFRR1Homo sapiens
G21RRLGLGPESRI2Mus musculus, Bos taurus
G21RRMGLGPESRI1Homo sapiens
G35RNLLTGLVRHE2Homo sapiens, Mus musculus
G35QNLLTGLVRHE1Bos taurus
H11AAAISHGRVYR2Mus musculus, Bos taurus
H11AAAISHGRVFR1Homo sapiens
H27PESRIHLLRNL2Homo sapiens, Mus musculus
H27PESRIHLLQNL1Bos taurus
H39TGLVRHERIEA3Homo sapiens, Mus musculus, Bos taurus
I42VRHERIEAPWA1Homo sapiens
I42VRHERIEATWA1Mus musculus
I42VRHERIEASWA1Bos taurus
I9SVAAAISHGRV1Homo sapiens
I9SLAAAISHGRV1Mus musculus
I9SFAAAISHGRV1Bos taurus
K119-LDRAKMAVIE1Homo sapiens
K119EQDRAKMAVIE1Mus musculus
K119QQDRAKMAVIE1Bos taurus
L115PNRS-LDRAKM1Homo sapiens
L115PNRKEQDRAKM1Mus musculus
L115PNRNQQDRAKM1Bos taurus
L20YRRLGLGPESR2Mus musculus, Bos taurus
L20FRRMGLGPESR1Homo sapiens
L32HLLRNLLTGLV2Homo sapiens, Mus musculus
L32HLLQNLLTGLV1Bos taurus
N31IHLLRNLLTGL2Homo sapiens, Mus musculus
N31IHLLQNLLTGL1Bos taurus
P22RLGLGPESRIH2Mus musculus, Bos taurus
P22RMGLGPESRIH1Homo sapiens
R117RS-LDRAKMAV1Homo sapiens
R117RKEQDRAKMAV1Mus musculus
R117RNQQDRAKMAV1Bos taurus
R13AISHGRVYRRL2Mus musculus, Bos taurus
R13AISHGRVFRRM1Homo sapiens
R16HGRVYRRLGLG2Mus musculus, Bos taurus
R16HGRVFRRMGLG1Homo sapiens
R17GRVYRRLGLGP2Mus musculus, Bos taurus
R17GRVFRRMGLGP1Homo sapiens
R48EAPWARVDEMR1Homo sapiens
R48EATWARADEMR1Mus musculus
R48EASWARVDELR1Bos taurus
S10VAAAISHGRVF1Homo sapiens
S10LAAAISHGRVY1Mus musculus
S10FAAAISHGRVY1Bos taurus
T81ADFWLTEKDLI3Homo sapiens, Mus musculus, Bos taurus
V14ISHGRVYRRLG2Mus musculus, Bos taurus
V14ISHGRVFRRMG1Homo sapiens


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