mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FIGNL1
Gene summary
Basic gene Info.Gene symbolFIGNL1
Gene namefidgetin-like 1
CytomapUCSC genome browser: 7p12.1
Type of geneprotein-coding
Descriptionfidgetin-like protein 1
Modification date20141207
dbXrefs MIM : 615383
Ensembl : ENSG00000132436
HPRD : 10958
Vega : OTTHUMG00000022866
ProteinUniProt: Q6PIW4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FIGNL1
BioGPS: 63979
PathwayNCI Pathway Interaction Database: FIGNL1
Pathway Commons: FIGNL1
ContextiHOP: FIGNL1
ligand binding site mutation search in PubMed: FIGNL1
UCL Cancer Institute: FIGNL1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0010569regulation of double-strand break repair via homologous recombination23754376
GO:0071479cellular response to ionizing radiation23754376

Ligand binding site mutations for FIGNL1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for FIGNL1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FIGNL1 from PDB

Differential gene expression and gene-gene network for FIGNL1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FIGNL1 and the right PPI network was created from samples without mutations in the LBS of FIGNL1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for FIGNL1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for FIGNL1
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FIGNL1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of FIGNL1
Multiple alignments for Q6PIW4 in multiple species
LBSAA sequence# speciesSpecies
A404NWEDIAGVEFA1Homo sapiens
A404AWEDIAGLESA1Drosophila melanogaster
A404NWDDIAGLEFA1Xenopus tropicalis
A404HWDDIAGVEFA1Mus musculus
A404HWEDIAGVEFA1Rattus norvegicus
A606DGFSGADMTQL3Xenopus tropicalis, Mus musculus, Rattus norvegicus
A606DAFSGADMTQL1Homo sapiens
A606DGYSGADVDTL1Drosophila melanogaster
D402PVNWEDIAGVE1Homo sapiens
D402PVAWEDIAGLE1Drosophila melanogaster
D402PLNWDDIAGLE1Xenopus tropicalis
D402PVHWDDIAGVE1Mus musculus
D402PVHWEDIAGVE1Rattus norvegicus
G395EIMDHGPPVHW2Mus musculus, Rattus norvegicus
G395EIMDHGPPVNW1Homo sapiens
G395ESMHDFKPVAW1Drosophila melanogaster
G395EIMDHGPPLNW1Xenopus tropicalis
G444LFGPPGTGKTL5Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus
G446GPPGTGKTLIG4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
G446GPPGTGKTLIA1Drosophila melanogaster
G605SDGFSGADMTQ2Mus musculus, Rattus norvegicus
G605SDAFSGADMTQ1Homo sapiens
G605TDGYSGADVDT1Drosophila melanogaster
G605ADGFSGADMTQ1Xenopus tropicalis
H394NEIMDHGPPVH2Mus musculus, Rattus norvegicus
H394NEIMDHGPPVN1Homo sapiens
H394GESMHDFKPVA1Drosophila melanogaster
H394SEIMDHGPPLN1Xenopus tropicalis
I576SARKQIVINLM1Homo sapiens
I576EARQKIIEKLI1Drosophila melanogaster
I576SARKQIVVSLM1Xenopus tropicalis
I576SARKQIVGNLM1Mus musculus
I576SARKQIVVNLM1Rattus norvegicus
K447PPGTGKTLIGK4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
K447PPGTGKTLIAK1Drosophila melanogaster
L449GTGKTLIGKCI4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
L449GTGKTLIAKSI1Drosophila melanogaster
P396IMDHGPPVNWE1Homo sapiens
P396SMHDFKPVAWE1Drosophila melanogaster
P396IMDHGPPLNWD1Xenopus tropicalis
P396IMDHGPPVHWD1Mus musculus
P396IMDHGPPVHWE1Rattus norvegicus
T445FGPPGTGKTLI5Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus
T448PGTGKTLIGKC4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
T448PGTGKTLIAKS1Drosophila melanogaster
T609SGADMTQLCRE4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
T609SGADVDTLCRY1Drosophila melanogaster

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