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mutLBSgeneDB |
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| Gene summary for FIGNL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | FIGNL1 |
| Gene name | fidgetin-like 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001042762.2, NM_001287492.1,NM_001287493.1,NM_001287494.1,NM_001287495.1, NM_001287496.1,NM_022116.4, | |
| Description | fidgetin-like protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615383 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132436 | ||
| HPRD : 10958 | ||
| Vega : OTTHUMG00000022866 | ||
| Protein | UniProt: Q6PIW4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FIGNL1 | |
| BioGPS: 63979 | ||
| Pathway | NCI Pathway Interaction Database: FIGNL1 | |
| KEGG: FIGNL1 | ||
| REACTOME: FIGNL1 | ||
| Pathway Commons: FIGNL1 | ||
| Context | iHOP: FIGNL1 | |
| ligand binding site mutation search in PubMed: FIGNL1 | ||
| UCL Cancer Institute: FIGNL1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 | GO:0071479 | cellular response to ionizing radiation | 23754376 |
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| Ligand binding site mutations for FIGNL1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A404 | G405V | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FIGNL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A404 | G405V | -0.51269536 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FIGNL1 from PDB |
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| Differential gene expression and gene-gene network for FIGNL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FIGNL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FIGNL1 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FIGNL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 3d8b | A | A404 | ADP | ADP | 3d8b | B | A404 |
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| Conservation information for LBS of FIGNL1 |
| Multiple alignments for Q6PIW4 in multiple species |
| LBS | AA sequence | # species | Species | A404 | NWEDIAGVEFA | 1 | Homo sapiens | A404 | AWEDIAGLESA | 1 | Drosophila melanogaster | A404 | NWDDIAGLEFA | 1 | Xenopus tropicalis | A404 | HWDDIAGVEFA | 1 | Mus musculus | A404 | HWEDIAGVEFA | 1 | Rattus norvegicus | A606 | DGFSGADMTQL | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | A606 | DAFSGADMTQL | 1 | Homo sapiens | A606 | DGYSGADVDTL | 1 | Drosophila melanogaster | D402 | PVNWEDIAGVE | 1 | Homo sapiens | D402 | PVAWEDIAGLE | 1 | Drosophila melanogaster | D402 | PLNWDDIAGLE | 1 | Xenopus tropicalis | D402 | PVHWDDIAGVE | 1 | Mus musculus | D402 | PVHWEDIAGVE | 1 | Rattus norvegicus | G395 | EIMDHGPPVHW | 2 | Mus musculus, Rattus norvegicus | G395 | EIMDHGPPVNW | 1 | Homo sapiens | G395 | ESMHDFKPVAW | 1 | Drosophila melanogaster | G395 | EIMDHGPPLNW | 1 | Xenopus tropicalis | G444 | LFGPPGTGKTL | 5 | Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus | G446 | GPPGTGKTLIG | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | G446 | GPPGTGKTLIA | 1 | Drosophila melanogaster | G605 | SDGFSGADMTQ | 2 | Mus musculus, Rattus norvegicus | G605 | SDAFSGADMTQ | 1 | Homo sapiens | G605 | TDGYSGADVDT | 1 | Drosophila melanogaster | G605 | ADGFSGADMTQ | 1 | Xenopus tropicalis | H394 | NEIMDHGPPVH | 2 | Mus musculus, Rattus norvegicus | H394 | NEIMDHGPPVN | 1 | Homo sapiens | H394 | GESMHDFKPVA | 1 | Drosophila melanogaster | H394 | SEIMDHGPPLN | 1 | Xenopus tropicalis | I576 | SARKQIVINLM | 1 | Homo sapiens | I576 | EARQKIIEKLI | 1 | Drosophila melanogaster | I576 | SARKQIVVSLM | 1 | Xenopus tropicalis | I576 | SARKQIVGNLM | 1 | Mus musculus | I576 | SARKQIVVNLM | 1 | Rattus norvegicus | K447 | PPGTGKTLIGK | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | K447 | PPGTGKTLIAK | 1 | Drosophila melanogaster | L449 | GTGKTLIGKCI | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | L449 | GTGKTLIAKSI | 1 | Drosophila melanogaster | P396 | IMDHGPPVNWE | 1 | Homo sapiens | P396 | SMHDFKPVAWE | 1 | Drosophila melanogaster | P396 | IMDHGPPLNWD | 1 | Xenopus tropicalis | P396 | IMDHGPPVHWD | 1 | Mus musculus | P396 | IMDHGPPVHWE | 1 | Rattus norvegicus | T445 | FGPPGTGKTLI | 5 | Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T448 | PGTGKTLIGKC | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T448 | PGTGKTLIAKS | 1 | Drosophila melanogaster | T609 | SGADMTQLCRE | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T609 | SGADVDTLCRY | 1 | Drosophila melanogaster |
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