mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SELE
Gene summary
Basic gene Info.Gene symbolSELE
Gene nameselectin E
CytomapUCSC genome browser: 1q22-q25
Type of geneprotein-coding
DescriptionCD62 antigen-like family member EE-selectinELAM-1endothelial adhesion molecule 1endothelial leukocyte adhesion molecule 1leukocyte endothelial cell adhesion molecule 2leukocyte-endothelial cell adhesion molecule 2
Modification date20141222
dbXrefs MIM : 131210
Ensembl : ENSG00000007908
HPRD : 00566
Vega : OTTHUMG00000034851
ProteinUniProt: P16581
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SELE
BioGPS: 6401
PathwayNCI Pathway Interaction Database: SELE
Pathway Commons: SELE
ContextiHOP: SELE
ligand binding site mutation search in PubMed: SELE
UCL Cancer Institute: SELE
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0002092positive regulation of receptor internalization9312078
GO:0007159leukocyte cell-cell adhesion7680663
GO:0030029actin filament-based process8609175
GO:0070555response to interleukin-18609175

Ligand binding site mutations for SELE

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SELE
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SELE from PDB

Differential gene expression and gene-gene network for SELE
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SELE and the right PPI network was created from samples without mutations in the LBS of SELE. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SELE
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007222Cardiovascular Diseases9Biomarker, GeneticVariation
umls:C0035126Reperfusion Injury3Biomarker
umls:C0020443Hypercholesterolemia3Biomarker, GeneticVariation
umls:C0026769Multiple Sclerosis3Biomarker, GeneticVariation
umls:C0007786Brain Ischemia3Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA2Biomarker, GeneticVariation
umls:C0011615Dermatitis, Atopic2Biomarker
umls:C0004238Atrial Fibrillation2AlteredExpression, Biomarker
umls:C0151744Myocardial Ischemia2Biomarker, GeneticVariation
umls:C0085580Hypertension, Essential2Biomarker, GeneticVariation
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SELE
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB01136CarvedilolSmall molecule
ExperimentalDB03721O-Sialic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SELE go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SELE
Multiple alignments for P16581 in multiple species
LBSAA sequence# speciesSpecies
D127VGMWNDERCSK1Homo sapiens
D127SGMWNDERCNK1Mus musculus
D127SGMWNDERCDK1Rattus norvegicus
E101NWAPGEPNNKQ2Mus musculus, Rattus norvegicus
E101NWAPGEPNNRQ1Homo sapiens
E109NKQRNEDCVEI2Mus musculus, Rattus norvegicus
E109NRQKDEDCVEI1Homo sapiens
E113NEDCVEIYIQR2Mus musculus, Rattus norvegicus
E113DEDCVEIYIKR1Homo sapiens
E119IYIKREKDVGM1Homo sapiens
E119IYIQRTKDSGM1Mus musculus
E119IYIQRPKDSGM1Rattus norvegicus
E128GMWNDERCSKK1Homo sapiens
E128GMWNDERCNKK1Mus musculus
E128GMWNDERCDKK1Rattus norvegicus
E54AIQNKEEINYL2Mus musculus, Rattus norvegicus
E54AIQNKEEIEYL1Homo sapiens
E57NKEEIEYLNSI1Homo sapiens
E57NKEEINYLNSN1Mus musculus
E57NKEEINYLNST1Rattus norvegicus
K120YIKREKDVGMW1Homo sapiens
K120YIQRTKDSGMW1Mus musculus
K120YIQRPKDSGMW1Rattus norvegicus
N103APGEPNNKQRN2Mus musculus, Rattus norvegicus
N103APGEPNNRQKD1Homo sapiens
N104PGEPNNKQRNE2Mus musculus, Rattus norvegicus
N104PGEPNNRQKDE1Homo sapiens
N126DVGMWNDERCS1Homo sapiens
N126DSGMWNDERCN1Mus musculus
N126DSGMWNDERCD1Rattus norvegicus
Q106EPNNKQRNEDC2Mus musculus, Rattus norvegicus
Q106EPNNRQKDEDC1Homo sapiens
Q41ASAYCQRDYTH2Mus musculus, Rattus norvegicus
Q41ASAYCQQRYTH1Homo sapiens
R105GEPNNKQRNED2Mus musculus, Rattus norvegicus
R105GEPNNRQKDED1Homo sapiens
R118EIYIKREKDVG1Homo sapiens
R118EIYIQRTKDSG1Mus musculus
R118EIYIQRPKDSG1Rattus norvegicus
Y115DCVEIYIKREK1Homo sapiens
Y115DCVEIYIQRTK1Mus musculus
Y115DCVEIYIQRPK1Rattus norvegicus
Y44YCQRDYTHLVA2Mus musculus, Rattus norvegicus
Y44YCQQRYTHLVA1Homo sapiens
Y69SYSPSYYWIGI1Homo sapiens
Y69KHSPSYYWIGI1Mus musculus
Y69RYSPSYYWIGI1Rattus norvegicus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas