mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SELP
Gene summary
Basic gene Info.Gene symbolSELP
Gene nameselectin P (granule membrane protein 140kDa, antigen CD62)
CytomapUCSC genome browser: 1q22-q25
Type of geneprotein-coding
DescriptionCD62 antigen-like family member PGMP-140P-selectingranule membrane protein 140granulocyte membrane proteinleukocyte-endothelial cell adhesion molecule 3platelet activation dependent granule-external membrane proteinplatelet alpha-granule membrane p
Modification date20141207
dbXrefs MIM : 173610
Ensembl : ENSG00000174175
HPRD : 01433
Vega : OTTHUMG00000034685
ProteinUniProt: P16109
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SELP
BioGPS: 6403
PathwayNCI Pathway Interaction Database: SELP
Pathway Commons: SELP
ContextiHOP: SELP
ligand binding site mutation search in PubMed: SELP
UCL Cancer Institute: SELP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0007159leukocyte cell-cell adhesion7680663
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling17632516

Ligand binding site mutations for SELP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SELP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SELP from PDB

Differential gene expression and gene-gene network for SELP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SELP and the right PPI network was created from samples without mutations in the LBS of SELP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SELP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension6Biomarker, GeneticVariation
umls:C0040053Thrombosis4Biomarker, GeneticVariation
umls:C0027055Myocardial Reperfusion Injury2Biomarker
umls:C0151744Myocardial Ischemia2Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SELP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB01109HeparinSmall molecule
ExperimentalDB03721O-Sialic AcidSmall molecule
ApprovedDB06779DalteparinSmall molecule
ApprovedDB08813NadroparinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SELP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SELP
Multiple alignments for P16109 in multiple species
LBSAA sequence# speciesSpecies
A50NYSTKAYSWNN2Mus musculus, Rattus norvegicus
A50HYSTKAYSWNI1Homo sapiens
D147PGKWNDEPCFK2Mus musculus, Rattus norvegicus
D147PGKWNDEHCLK1Homo sapiens
E121NWADNEPNNKR2Homo sapiens, Rattus norvegicus
E121NWADNEPNNKK1Mus musculus
E129NKRNNEDCVEI1Homo sapiens
E129NKKNNQDCVEI1Mus musculus
E129NKRNNQDCVEI1Rattus norvegicus
E133NQDCVEIYIKS2Mus musculus, Rattus norvegicus
E133NEDCVEIYIKS1Homo sapiens
E148GKWNDEPCFKR2Mus musculus, Rattus norvegicus
E148GKWNDEHCLKK1Homo sapiens
H149KWNDEPCFKRK2Mus musculus, Rattus norvegicus
H149KWNDEHCLKKK1Homo sapiens
H155CFKRKRALCYT2Mus musculus, Rattus norvegicus
H155CLKKKHALCYT1Homo sapiens
K125NEPNNKRNNED1Homo sapiens
K125NEPNNKKNNQD1Mus musculus
K125NEPNNKRNNQD1Rattus norvegicus
K152DEPCFKRKRAL2Mus musculus, Rattus norvegicus
K152DEHCLKKKHAL1Homo sapiens
K153EPCFKRKRALC2Mus musculus, Rattus norvegicus
K153EHCLKKKHALC1Homo sapiens
L151NDEPCFKRKRA2Mus musculus, Rattus norvegicus
L151NDEHCLKKKHA1Homo sapiens
N123ADNEPNNKRNN2Homo sapiens, Rattus norvegicus
N123ADNEPNNKKNN1Mus musculus
N124DNEPNNKRNNE1Homo sapiens
N124DNEPNNKKNNQ1Mus musculus
N124DNEPNNKRNNQ1Rattus norvegicus
N146APGKWNDEPCF2Mus musculus, Rattus norvegicus
N146APGKWNDEHCL1Homo sapiens
P139IYIKSNSAPGK2Mus musculus, Rattus norvegicus
P139IYIKSPSAPGK1Homo sapiens
R126EPNNKRNNEDC1Homo sapiens
R126EPNNKKNNQDC1Mus musculus
R126EPNNKRNNQDC1Rattus norvegicus
S140YIKSNSAPGKW2Mus musculus, Rattus norvegicus
S140YIKSPSAPGKW1Homo sapiens
S87VLPYYSSYYWI1Homo sapiens
S87VIPFFNSYYWI1Mus musculus
S87VIPYVNSYYWI1Rattus norvegicus
S88LPYYSSYYWIG1Homo sapiens
S88IPFFNSYYWIG1Mus musculus
S88IPYVNSYYWIG1Rattus norvegicus
Y135DCVEIYIKSNS2Mus musculus, Rattus norvegicus
Y135DCVEIYIKSPS1Homo sapiens
Y86KVLPYYSSYYW1Homo sapiens
Y86DVIPFFNSYYW1Mus musculus
Y86DVIPYVNSYYW1Rattus norvegicus
Y89PYYSSYYWIGI1Homo sapiens
Y89PFFNSYYWIGI1Mus musculus
Y89PYVNSYYWIGI1Rattus norvegicus

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