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mutLBSgeneDB |
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| Gene summary for SELP |
 Gene summary |
| Basic gene Info. | Gene symbol | SELP |
| Gene name | selectin P (granule membrane protein 140kDa, antigen CD62) | |
| Synonyms | CD62|CD62P|GMP140|GRMP|LECAM3|PADGEM|PSEL | |
| Cytomap | UCSC genome browser: 1q22-q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003005.3, | |
| Description | CD62 antigen-like family member PGMP-140P-selectingranule membrane protein 140granulocyte membrane proteinleukocyte-endothelial cell adhesion molecule 3platelet activation dependent granule-external membrane proteinplatelet alpha-granule membrane p | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 173610 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000174175 | ||
| HPRD : 01433 | ||
| Vega : OTTHUMG00000034685 | ||
| Protein | UniProt: P16109 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SELP | |
| BioGPS: 6403 | ||
| Pathway | NCI Pathway Interaction Database: SELP | |
| KEGG: SELP | ||
| REACTOME: SELP | ||
| Pathway Commons: SELP | ||
| Context | iHOP: SELP | |
| ligand binding site mutation search in PubMed: SELP | ||
| UCL Cancer Institute: SELP | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007159 | leukocyte cell-cell adhesion | 7680663 | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 17632516 |
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| Ligand binding site mutations for SELP |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S140 | P142H | LUAD | 1 | R126 | N127S | LUAD | 1 | E129 | D130N | LUSC | 1 | N146 | K144N | SKCM | 1 | P139 | P139Q | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SELP |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S140 | P142H | -1.445193 | N146 | K144N | -1.425182 | E129 | D130N | -1.3310785 | R126 | N127S | -1.1668592 | P139 | P139Q | -0.86741136 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SELP from PDB |
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| Differential gene expression and gene-gene network for SELP |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SELP |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0020538 | Hypertension | 6 | Biomarker, GeneticVariation |
| umls:C0040053 | Thrombosis | 4 | Biomarker, GeneticVariation |
| umls:C0027055 | Myocardial Reperfusion Injury | 2 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 2 | Biomarker |
| umls:C0020517 | Hypersensitivity | 1 | Biomarker |
| umls:C0031117 | Peripheral Nervous System Diseases | 1 | Biomarker |
| umls:C0032231 | Pleurisy | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SELP |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB01109 | Heparin | Small molecule |  |
| Experimental | DB03721 | O-Sialic Acid | Small molecule |  |
| Approved | DB06779 | Dalteparin | Small molecule |  |
| Approved | DB08813 | Nadroparin | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SELP go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of SELP |
| Multiple alignments for P16109 in multiple species |
| LBS | AA sequence | # species | Species | A50 | NYSTKAYSWNN | 2 | Mus musculus, Rattus norvegicus | A50 | HYSTKAYSWNI | 1 | Homo sapiens | D147 | PGKWNDEPCFK | 2 | Mus musculus, Rattus norvegicus | D147 | PGKWNDEHCLK | 1 | Homo sapiens | E121 | NWADNEPNNKR | 2 | Homo sapiens, Rattus norvegicus | E121 | NWADNEPNNKK | 1 | Mus musculus | E129 | NKRNNEDCVEI | 1 | Homo sapiens | E129 | NKKNNQDCVEI | 1 | Mus musculus | E129 | NKRNNQDCVEI | 1 | Rattus norvegicus | E133 | NQDCVEIYIKS | 2 | Mus musculus, Rattus norvegicus | E133 | NEDCVEIYIKS | 1 | Homo sapiens | E148 | GKWNDEPCFKR | 2 | Mus musculus, Rattus norvegicus | E148 | GKWNDEHCLKK | 1 | Homo sapiens | H149 | KWNDEPCFKRK | 2 | Mus musculus, Rattus norvegicus | H149 | KWNDEHCLKKK | 1 | Homo sapiens | H155 | CFKRKRALCYT | 2 | Mus musculus, Rattus norvegicus | H155 | CLKKKHALCYT | 1 | Homo sapiens | K125 | NEPNNKRNNED | 1 | Homo sapiens | K125 | NEPNNKKNNQD | 1 | Mus musculus | K125 | NEPNNKRNNQD | 1 | Rattus norvegicus | K152 | DEPCFKRKRAL | 2 | Mus musculus, Rattus norvegicus | K152 | DEHCLKKKHAL | 1 | Homo sapiens | K153 | EPCFKRKRALC | 2 | Mus musculus, Rattus norvegicus | K153 | EHCLKKKHALC | 1 | Homo sapiens | L151 | NDEPCFKRKRA | 2 | Mus musculus, Rattus norvegicus | L151 | NDEHCLKKKHA | 1 | Homo sapiens | N123 | ADNEPNNKRNN | 2 | Homo sapiens, Rattus norvegicus | N123 | ADNEPNNKKNN | 1 | Mus musculus | N124 | DNEPNNKRNNE | 1 | Homo sapiens | N124 | DNEPNNKKNNQ | 1 | Mus musculus | N124 | DNEPNNKRNNQ | 1 | Rattus norvegicus | N146 | APGKWNDEPCF | 2 | Mus musculus, Rattus norvegicus | N146 | APGKWNDEHCL | 1 | Homo sapiens | P139 | IYIKSNSAPGK | 2 | Mus musculus, Rattus norvegicus | P139 | IYIKSPSAPGK | 1 | Homo sapiens | R126 | EPNNKRNNEDC | 1 | Homo sapiens | R126 | EPNNKKNNQDC | 1 | Mus musculus | R126 | EPNNKRNNQDC | 1 | Rattus norvegicus | S140 | YIKSNSAPGKW | 2 | Mus musculus, Rattus norvegicus | S140 | YIKSPSAPGKW | 1 | Homo sapiens | S87 | VLPYYSSYYWI | 1 | Homo sapiens | S87 | VIPFFNSYYWI | 1 | Mus musculus | S87 | VIPYVNSYYWI | 1 | Rattus norvegicus | S88 | LPYYSSYYWIG | 1 | Homo sapiens | S88 | IPFFNSYYWIG | 1 | Mus musculus | S88 | IPYVNSYYWIG | 1 | Rattus norvegicus | Y135 | DCVEIYIKSNS | 2 | Mus musculus, Rattus norvegicus | Y135 | DCVEIYIKSPS | 1 | Homo sapiens | Y86 | KVLPYYSSYYW | 1 | Homo sapiens | Y86 | DVIPFFNSYYW | 1 | Mus musculus | Y86 | DVIPYVNSYYW | 1 | Rattus norvegicus | Y89 | PYYSSYYWIGI | 1 | Homo sapiens | Y89 | PFFNSYYWIGI | 1 | Mus musculus | Y89 | PYVNSYYWIGI | 1 | Rattus norvegicus |
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