mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RBKS
Gene summary
Basic gene Info.Gene symbolRBKS
Gene nameribokinase
CytomapUCSC genome browser: 2p23.3
Type of geneprotein-coding
Modification date20141207
dbXrefs MIM : 611132
HPRD : 15222
ProteinUniProt: Q9H477
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RBKS
BioGPS: 64080
PathwayNCI Pathway Interaction Database: RBKS
Pathway Commons: RBKS
ContextiHOP: RBKS
ligand binding site mutation search in PubMed: RBKS
UCL Cancer Institute: RBKS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for RBKS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RBKS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RBKS from PDB

Differential gene expression and gene-gene network for RBKS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RBKS and the right PPI network was created from samples without mutations in the LBS of RBKS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RBKS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RBKS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RBKS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of RBKS
Multiple alignments for Q9H477 in multiple species
LBSAA sequence# speciesSpecies
A238IITLGAEGCVV1Homo sapiens
A238VMTLGSRGVLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A238IITLGSQGA-Y1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A238VITLGASGCVI1Mus musculus
A267VDTTGAGDSFV2Homo sapiens, Mus musculus
A267VDTTGAGDTFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A267VDTTAAGDTFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A298RSNFIAAVSVQ2Homo sapiens, Mus musculus
A298FSTLASSLTIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A298FAAKCSAITVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A299SNFIAAVSVQA2Homo sapiens, Mus musculus
A299STLASSLTIQR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A299AAKCSAITVQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E257HIPT-EKVKAV1Homo sapiens
E257FLPAIQNVSVV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E257LVSA-CKVKAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E257HIPT-EAVKAV1Mus musculus
G237VIITLGAEGCV1Homo sapiens
G237VVMTLGSRGVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G237VIITLGSQGA-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G237VVITLGASGCV1Mus musculus
G240TLGAEGCVVLS1Homo sapiens
G240TLGSRGVLFCS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G240TLGSQGA-YYK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G240TLGASGCVILS1Mus musculus
G268DTTGAGDSFVG2Homo sapiens, Mus musculus
G268DTTGAGDTFLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G268DTTAAGDTFIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L236VVIITLGAEGC1Homo sapiens
L236IVVMTLGSRGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L236AVIITLGSQGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L236VVVITLGASGC1Mus musculus
N199DVFCCNESEAE1Homo sapiens
N199DLLVVNEIEGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N199AYLVPNEHEAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N199SIFCCNESEAE1Mus musculus
N295MLNRSNFIAAV1Homo sapiens
N295AIKFSTLASSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N295SLEFAAKCSAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N295MLKRSNFIAAV1Mus musculus
T235-VVIITLGAEG1Homo sapiens
T235GIVVMTLGSRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T235KAVIITLGSQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T235-VVVITLGASG1Mus musculus
T256PKHIPT-EKVK1Homo sapiens
T256VQFLPAIQNVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T256SALVSA-CKVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T256PKHIPT-EAVK1Mus musculus
V259PT-EKVKAVDT1Homo sapiens
V259PAIQNVSVVDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V259SA-CKVKAVDT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V259PT-EAVKAVDT1Mus musculus
V302IAAVSVQAAGT1Homo sapiens
V302ASSLTIQRKGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V302CSAITVQRKGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V302IAAVSVQATGT1Mus musculus

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