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mutLBSgeneDB |
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| Gene summary for MPP5 |
 Gene summary |
| Basic gene Info. | Gene symbol | MPP5 |
| Gene name | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | |
| Synonyms | PALS1 | |
| Cytomap | UCSC genome browser: 14q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256550.1, NM_022474.3, | |
| Description | MAGUK p55 subfamily member 5protein associated with lin seven 1stardust | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606958 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000072415 | ||
| HPRD : 09508 | ||
| Vega : OTTHUMG00000171243 | ||
| Protein | UniProt: Q8N3R9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MPP5 | |
| BioGPS: 64398 | ||
| Pathway | NCI Pathway Interaction Database: MPP5 | |
| KEGG: MPP5 | ||
| REACTOME: MPP5 | ||
| Pathway Commons: MPP5 | ||
| Context | iHOP: MPP5 | |
| ligand binding site mutation search in PubMed: MPP5 | ||
| UCL Cancer Institute: MPP5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MPP5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R272 | R272C | COAD | 1 | E368,C366 | R367Q | HNSC | 1 | P512,R516 | T514A | HNSC | 1 | R263 | D264H | LUSC | 1 | R578 | R578S | LUSC | 1 | R578 | T579A | STAD | 1 | Q488 | N489T | UCEC | 1 | R496 | R496C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MPP5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R578 | R578S | -1.2870606 | R516 | T514A | -1.0005133 | P512 | T514A | -1.0005133 | Q488 | N489T | -0.93398539 | R578 | T579A | -0.59689867 | E368 | R367Q | -0.58518982 | C366 | R367Q | -0.58518982 | R272 | R272C | -0.4385533 | R496 | R496C | -0.28538252 | R263 | D264H | -0.27747708 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MPP5 from PDB |
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| Differential gene expression and gene-gene network for MPP5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MPP5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MPP5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MPP5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (PRO,ARG,LEU,GLU,MET,ASP,ASN,VAL,LEU,LYS,PRO,PRO,PRO,GLU,GLU,ARG,LEU,ILE) | 4wsi | A | E368 R496 P512 R516 R578 | PUN | 2,2,4,4,6,6,8-HEPTAMETHYLNONANE | 4uu5 | A | R263 | III | Peptide ligand (MET,TRP,ASN,LEU,MET,PRO,PRO,PRO,ALA,MET,GLU,ARG,LEU,ILE) | 4uu5 | A | R272 | III | Peptide ligand (PRO,ARG,LEU,GLU,MET,ASP,ASN,VAL,LEU,LYS,PRO,PRO,PRO,GLU,GLU,ARG,LEU,ILE) | 4wsi | B | R272 C366 E368 Q488 R516 R578 |
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| Conservation information for LBS of MPP5 |
| Multiple alignments for Q8N3R9 in multiple species |
| LBS | AA sequence | # species | Species | A269 | DIPLGATVRNE | 2 | Homo sapiens, Mus musculus | A269 | DIPLGATVRND | 1 | Danio rerio | C366 | DPYVPCRELGL | 3 | Homo sapiens, Danio rerio, Mus musculus | D527 | EVAGRDYHFVS | 2 | Homo sapiens, Mus musculus | D527 | EANGRDYHFVS | 1 | Danio rerio | E368 | YVPCRELGLSF | 2 | Homo sapiens, Mus musculus | E368 | YVPCRELGLCF | 1 | Danio rerio | E547 | AGKFIEHGEFE | 2 | Homo sapiens, Mus musculus | E547 | AGKFIESGEFE | 1 | Danio rerio | F318 | DVNEVFDLLSD | 2 | Homo sapiens, Mus musculus | F318 | DVNEVFDILAD | 1 | Danio rerio | F551 | IEHGEFEKNLY | 2 | Homo sapiens, Mus musculus | F551 | IESGEFEKNFY | 1 | Danio rerio | G268 | RDIPLGATVRN | 2 | Homo sapiens, Mus musculus | G268 | KDIPLGATVRN | 1 | Danio rerio | G549 | KFIEHGEFEKN | 2 | Homo sapiens, Mus musculus | G549 | KFIESGEFEKN | 1 | Danio rerio | H325 | LLSDMHGTLTF | 2 | Homo sapiens, Mus musculus | H325 | ILADMHGVLSF | 1 | Danio rerio | L267 | ARDIPLGATVR | 2 | Homo sapiens, Mus musculus | L267 | AKDIPLGATVR | 1 | Danio rerio | L321 | EVFDLLSDMHG | 2 | Homo sapiens, Mus musculus | L321 | EVFDILADMHG | 1 | Danio rerio | L369 | VPCRELGLSFQ | 2 | Homo sapiens, Mus musculus | L369 | VPCRELGLCFQ | 1 | Danio rerio | L577 | ICLLSLRTQSL | 2 | Homo sapiens, Mus musculus | L577 | ICLLCVHTQSL | 1 | Danio rerio | N273 | GATVRNEMDSV | 2 | Homo sapiens, Mus musculus | N273 | GATVRNDMDSV | 1 | Danio rerio | N315 | RGKDVNEVFDL | 2 | Homo sapiens, Mus musculus | N315 | RGKDVNEVFDI | 1 | Danio rerio | N493 | QNCGQNELRQR | 2 | Homo sapiens, Mus musculus | N493 | PNCGQNELRQR | 1 | Danio rerio | P266 | KARDIPLGATV | 2 | Homo sapiens, Mus musculus | P266 | KAKDIPLGATV | 1 | Danio rerio | P365 | DDPYVPCRELG | 3 | Homo sapiens, Danio rerio, Mus musculus | P512 | FASAVPHTTRS | 1 | Homo sapiens | P512 | FAGPVPHTTRS | 1 | Danio rerio | P512 | FASAVPHTTRN | 1 | Mus musculus | Q488 | ILIGPQNCGQN | 2 | Homo sapiens, Mus musculus | Q488 | ALIGPPNCGQN | 1 | Danio rerio | Q497 | QNELRQRLMNK | 2 | Homo sapiens, Mus musculus | Q497 | QNELRQRLLST | 1 | Danio rerio | R263 | RIEKARDIPLG | 2 | Homo sapiens, Mus musculus | R263 | RIEKAKDIPLG | 1 | Danio rerio | R272 | LGATVRNEMDS | 2 | Homo sapiens, Mus musculus | R272 | LGATVRNDMDS | 1 | Danio rerio | R282 | SVIISRIVKGG | 2 | Homo sapiens, Mus musculus | R282 | SVVISRIVKGG | 1 | Danio rerio | R496 | GQNELRQRLMN | 2 | Homo sapiens, Mus musculus | R496 | GQNELRQRLLS | 1 | Danio rerio | R516 | VPHTTRSRRDQ | 1 | Homo sapiens | R516 | VPHTTRSRRDA | 1 | Danio rerio | R516 | VPHTTRNRRDH | 1 | Mus musculus | R526 | QEVAGRDYHFV | 1 | Homo sapiens | R526 | AEANGRDYHFV | 1 | Danio rerio | R526 | HEVAGRDYHFV | 1 | Mus musculus | R578 | CLLSLRTQSLK | 2 | Homo sapiens, Mus musculus | R578 | CLLCVHTQSLK | 1 | Danio rerio | S281 | DSVIISRIVKG | 2 | Homo sapiens, Mus musculus | S281 | DSVVISRIVKG | 1 | Danio rerio | S509 | KDRFASAVPHT | 2 | Homo sapiens, Mus musculus | S509 | PDRFAGPVPHT | 1 | Danio rerio | S576 | KICLLSLRTQS | 2 | Homo sapiens, Mus musculus | S576 | KICLLCVHTQS | 1 | Danio rerio | T270 | IPLGATVRNEM | 2 | Homo sapiens, Mus musculus | T270 | IPLGATVRNDM | 1 | Danio rerio | T558 | KNLYGTSIDSV | 2 | Homo sapiens, Mus musculus | T558 | KNFYGTSTDSV | 1 | Danio rerio | V271 | PLGATVRNEMD | 2 | Homo sapiens, Mus musculus | V271 | PLGATVRNDMD | 1 | Danio rerio | V314 | IRGKDVNEVFD | 3 | Homo sapiens, Danio rerio, Mus musculus | Y528 | VAGRDYHFVSR | 2 | Homo sapiens, Mus musculus | Y528 | ANGRDYHFVSR | 1 | Danio rerio | Y556 | FEKNLYGTSID | 2 | Homo sapiens, Mus musculus | Y556 | FEKNFYGTSTD | 1 | Danio rerio |
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