mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SFTPD
Gene summary
Basic gene Info.Gene symbolSFTPD
Gene namesurfactant protein D
CytomapUCSC genome browser: 10q22.2-q23.1
Type of geneprotein-coding
Descriptioncollectin 7collectin-7lung surfactant protein Dpulmonary surfactant apoproteinpulmonary surfactant-associated protein Dsurfactant, pulmonary-associated protein Dsurfactant-associated protein, pulmonary 4
Modification date20141222
dbXrefs MIM : 178635
Ensembl : ENSG00000133661
HPRD : 01522
Vega : OTTHUMG00000018590
ProteinUniProt: P35247
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SFTPD
BioGPS: 6441
PathwayNCI Pathway Interaction Database: SFTPD
Pathway Commons: SFTPD
ContextiHOP: SFTPD
ligand binding site mutation search in PubMed: SFTPD
UCL Cancer Institute: SFTPD
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for SFTPD
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SFTPD
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SFTPD from PDB

Differential gene expression and gene-gene network for SFTPD
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SFTPD and the right PPI network was created from samples without mutations in the LBS of SFTPD. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SFTPD
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024121Lung Neoplasms4AlteredExpression, Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SFTPD
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02379Beta-D-GlucoseSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SFTPD go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SFTPD
Multiple alignments for P35247 in multiple species
LBSAA sequence# speciesSpecies
D317FLSMTDVGTEG2Mus musculus, Rattus norvegicus
D317FLSMTDSKTEG1Homo sapiens
D317FLSMSDTRKEG1Bos taurus
D317FLSMNDISTEG1Bos taurus
D317YLSMNDISTEG1Bos taurus
D317FLSMTDSKMEG1Macaca mulatta
D344PGEPNDD--GG2Homo sapiens, Macaca mulatta
D344PGEPNNN--GG2Mus musculus, Rattus norvegicus
D344PQEPNND--GG1Bos taurus
D344SGEPNNNNAGQ1Bos taurus
D344DGEPNNSDEGQ1Bos taurus
D345GEPNDD--GGS2Homo sapiens, Macaca mulatta
D345GEPNNN--GGA2Mus musculus, Rattus norvegicus
D345QEPNND--GGS1Bos taurus
D345GEPNNNNAGQP1Bos taurus
D345GEPNNSDEGQP1Bos taurus
D350-GGSEDCVEIF2Homo sapiens, Macaca mulatta
D350-GGAENCVEIF2Mus musculus, Rattus norvegicus
D350-GGSENCVEIF1Bos taurus
D350AGQPENCVQIY1Bos taurus
D350EGQPENCVEIF1Bos taurus
D362NGKWNDRACGE2Homo sapiens, Macaca mulatta
D362NGQWNDKACGE2Mus musculus, Rattus norvegicus
D362NGKWNDKVCGE1Bos taurus
D362EGKWNDVPCSE1Bos taurus
D362DGKWNDVPCSK1Bos taurus
E252QYKKVELFPNG2Homo sapiens, Macaca mulatta
E252QYKKAMLFPNG1Bos taurus
E252RYKKAVLFPDG1Bos taurus
E252QYKKAVLFPDG1Bos taurus
E252HYQKAALFPDG1Mus musculus
E252RYKKAALFPDG1Rattus norvegicus
E321TDVGTEGKFTY2Mus musculus, Rattus norvegicus
E321TDSKTEGKFTY1Homo sapiens
E321SDTRKEGTFIY1Bos taurus
E321NDISTEGKFTY1Bos taurus
E321NDISTEGRFTY1Bos taurus
E321TDSKMEGKFTY1Macaca mulatta
E341NWAPGEPNDD-2Homo sapiens, Macaca mulatta
E341NWAPGEPNNN-2Mus musculus, Rattus norvegicus
E341NWAPQEPNND-1Bos taurus
E341NWASGEPNNNN1Bos taurus
E341NWADGEPNNSD1Bos taurus
E349--GGSEDCVEI2Homo sapiens, Macaca mulatta
E349--GGAENCVEI2Mus musculus, Rattus norvegicus
E349--GGSENCVEI1Bos taurus
E349NAGQPENCVQI1Bos taurus
E349DEGQPENCVEI1Bos taurus
E353SEDCVEIFTNG2Homo sapiens, Macaca mulatta
E353AENCVEIFTNG2Mus musculus, Rattus norvegicus
E353SENCVEIFPNG1Bos taurus
E353PENCVQIYREG1Bos taurus
E353PENCVEIFPDG1Bos taurus
E367DRACGEKRLVV2Homo sapiens, Macaca mulatta
E367DKACGEQRLVI2Mus musculus, Rattus norvegicus
E367DKVCGEQRLVI1Bos taurus
E367DVPCSEPLLVI1Bos taurus
E367DVPCSKQLLVI1Bos taurus
F324GTEGKFTYPTG2Mus musculus, Rattus norvegicus
F324KTEGKFTYPTG1Homo sapiens
F324RKEGTFIYPTG1Bos taurus
F324STEGKFTYPTG1Bos taurus
F324STEGRFTYPTG1Bos taurus
F324KMEGKFTYPTG1Macaca mulatta
F355DCVEIFTNGKW2Homo sapiens, Macaca mulatta
F355NCVEIFTNGQW2Mus musculus, Rattus norvegicus
F355NCVEIFPNGKW1Bos taurus
F355NCVQIYREGKW1Bos taurus
F355NCVEIFPDGKW1Bos taurus
K266GEKIFKTAGFV2Homo sapiens, Macaca mulatta
K266GEKIFKTEGSE1Bos taurus
K266GKKIFKTAGAV1Bos taurus
K266GEKIFKTAGAV1Bos taurus
K266GDKIFRTADSE1Mus musculus
K266GDKIFRAANSE1Rattus norvegicus
N343APGEPNDD--G2Homo sapiens, Macaca mulatta
N343APGEPNNN--G2Mus musculus, Rattus norvegicus
N343APQEPNND--G1Bos taurus
N343ASGEPNNNNAG1Bos taurus
N343ADGEPNNSDEG1Bos taurus
N357VEIFTNGKWND2Homo sapiens, Macaca mulatta
N357VEIFTNGQWND2Mus musculus, Rattus norvegicus
N357VEIFPNGKWND1Bos taurus
N357VQIYREGKWND1Bos taurus
N357VEIFPDGKWND1Bos taurus
N361TNGKWNDRACG2Homo sapiens, Macaca mulatta
N361TNGQWNDKACG2Mus musculus, Rattus norvegicus
N361PNGKWNDKVCG1Bos taurus
N361REGKWNDVPCS1Bos taurus
N361PDGKWNDVPCS1Bos taurus
R363GKWNDRACGEK2Homo sapiens, Macaca mulatta
R363GQWNDKACGEQ2Mus musculus, Rattus norvegicus
R363GKWNDKVCGEQ1Bos taurus
R363GKWNDVPCSEP1Bos taurus
R363GKWNDVPCSKQ1Bos taurus
R369ACGEKRLVVCE2Homo sapiens, Macaca mulatta
R369ACGEQRLVICE2Mus musculus, Rattus norvegicus
R369VCGEQRLVICE1Bos taurus
R369PCSEPLLVICE1Bos taurus
R369PCSKQLLVICE1Bos taurus
T356CVEIFTNGKWN2Homo sapiens, Macaca mulatta
T356CVEIFTNGQWN2Mus musculus, Rattus norvegicus
T356CVEIFPNGKWN1Bos taurus
T356CVQIYREGKWN1Bos taurus
T356CVEIFPDGKWN1Bos taurus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas