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mutLBSgeneDB |
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| Gene summary for SGK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | SGK1 |
| Gene name | serum/glucocorticoid regulated kinase 1 | |
| Synonyms | SGK | |
| Cytomap | UCSC genome browser: 6q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001143676.1, NM_001143677.1,NM_001143678.1,NM_001291995.1,NM_005627.3, | |
| Description | Sgk1 variant i3serine/threonine protein kinase SGKserine/threonine-protein kinase Sgk1serum/glucocorticoid-regulated kinase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602958 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118515 | ||
| HPRD : 04264 | ||
| Vega : OTTHUMG00000015613 | ||
| Protein | UniProt: O00141 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SGK1 | |
| BioGPS: 6446 | ||
| Pathway | NCI Pathway Interaction Database: SGK1 | |
| KEGG: SGK1 | ||
| REACTOME: SGK1 | ||
| Pathway Commons: SGK1 | ||
| Context | iHOP: SGK1 | |
| ligand binding site mutation search in PubMed: SGK1 | ||
| UCL Cancer Institute: SGK1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for SGK1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I179,E183 | G181R | KIRC | 1 | K127 | K127N | LUAD | 1 | V112 | L113F | UCEC | 1 | L229 | D231E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SGK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K127 | K127N | 0.1115888 | E183 | G181R | 0.090737642 | I179 | G181R | 0.090737642 | V112 | L113F | -1.0987607 | L229 | D231E | -0.24290129 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SGK1 from PDB |
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| Differential gene expression and gene-gene network for SGK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SGK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007097 | Carcinoma | 2 | Biomarker |
| umls:C0011882 | Diabetic Neuropathies | 1 | Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0041948 | Uremia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SGK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03247 | Riboflavin Monophosphate | Small molecule |  |
| Experimental | DB07837 | [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid | Small molecule |  |
| Experimental | DB08191 | 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SGK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 2r5t | A | K127 I179 L229 | MMG | 4-(5-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)BENZOIC ACID | 3hdm | A | V112 K127 I179 E183 L229 | GMG | [4-(5-NAPHTHALEN-2-YL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PHENYL]ACETIC ACID | 3hdn | A | V112 K127 I179 L229 |
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| Conservation information for LBS of SGK1 |
| Multiple alignments for O00141 in multiple species |
| LBS | AA sequence | # species | Species | A125 | EEVFYAVKVLQ | 2 | Homo sapiens, Mus musculus | A125 | DEKFYAVKVLQ | 2 | Danio rerio, Xenopus tropicalis | A125 | TKKIYAMKILS | 1 | Caenorhabditis elegans | A125 | EEQFYAVKVLQ | 1 | Gallus gallus | A125 | EEAFYAVKVLQ | 1 | Bos taurus | D177 | LYFVLDYINGG | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Bos taurus | D177 | LYFVLDHLNGG | 1 | Caenorhabditis elegans | D177 | LYFILDYINGG | 1 | Xenopus tropicalis | E183 | YINGGELFYHL | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | E183 | HLNGGELFSHL | 1 | Caenorhabditis elegans | E226 | RDLKPENILLD | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | E226 | RDLKPENLLLD | 1 | Caenorhabditis elegans | F109 | IGKGSFGKVLL | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | F109 | IGKGSFGRVYQ | 1 | Caenorhabditis elegans | G107 | KVIGKGSFGKV | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Bos taurus | G107 | TTIGKGSFGRV | 1 | Caenorhabditis elegans | G107 | KIIGKGSFGKV | 1 | Xenopus tropicalis | I104 | HFLKVIGKGSF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Bos taurus | I104 | DYLTTIGKGSF | 1 | Caenorhabditis elegans | I104 | DFLKVIGKGSF | 1 | Danio rerio | I104 | QFLKIIGKGSF | 1 | Xenopus tropicalis | I179 | FVLDYINGGEL | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Bos taurus | I179 | FVLDHLNGGEL | 1 | Caenorhabditis elegans | I179 | FILDYINGGEL | 1 | Xenopus tropicalis | K127 | VFYAVKVLQKK | 2 | Homo sapiens, Mus musculus | K127 | KFYAVKVLQKK | 2 | Danio rerio, Xenopus tropicalis | K127 | KIYAMKILSKE | 1 | Caenorhabditis elegans | K127 | QFYAVKVLQKK | 1 | Gallus gallus | K127 | AFYAVKVLQKK | 1 | Bos taurus | K224 | VYRDLKPENIL | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | K224 | IYRDLKPENLL | 1 | Caenorhabditis elegans | L176 | KLYFVLDYING | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Bos taurus | L176 | KLYFVLDHLNG | 1 | Caenorhabditis elegans | L176 | RLYFILDYING | 1 | Xenopus tropicalis | L229 | KPENILLDSQG | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | L229 | KPENLLLDDKG | 1 | Caenorhabditis elegans | N227 | DLKPENILLDS | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | N227 | DLKPENLLLDD | 1 | Caenorhabditis elegans | S108 | VIGKGSFGKVL | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Bos taurus | S108 | TIGKGSFGRVY | 1 | Caenorhabditis elegans | S108 | IIGKGSFGKVL | 1 | Xenopus tropicalis | T239 | GHIVLTDFGLC | 4 | Homo sapiens, Gallus gallus, Mus musculus, Bos taurus | T239 | GHIILTDFGLC | 2 | Danio rerio, Xenopus tropicalis | T239 | GYLVLTDFGLC | 1 | Caenorhabditis elegans | V112 | GSFGKVLLARH | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | V112 | GSFGRVYQVRH | 1 | Caenorhabditis elegans | V160 | KHPFLVGLHFS | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | V160 | KHPFLVSLHFS | 1 | Caenorhabditis elegans | V160 | KHPFLVGLHYS | 1 | Danio rerio |
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