mutLBSgeneDB |
Gene summary for BLVRB |
Gene summary |
Basic gene Info. | Gene symbol | BLVRB |
Gene name | biliverdin reductase B | |
Synonyms | BVRB|FLR|HEL-S-10|SDR43U1 | |
Cytomap | UCSC genome browser: 19q13.1-q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_000713.2, | |
Description | BVR-BFRGHBPNADPH-dependent diaphoraseNADPH-flavin reductasebiliverdin reductase B (flavin reductase (NADPH))biliverdin-IX beta-reductaseepididymis secretory protein Li 10flavin reductase (NADPH)green heme-binding proteinshort chain dehydrogenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 600941 | |
HGNC : HGNC | ||
Ensembl : ENSG00000090013 | ||
HPRD : 02967 | ||
Vega : OTTHUMG00000182593 | ||
Protein | UniProt: P30043 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BLVRB | |
BioGPS: 645 | ||
Pathway | NCI Pathway Interaction Database: BLVRB | |
KEGG: BLVRB | ||
REACTOME: BLVRB | ||
Pathway Commons: BLVRB | ||
Context | iHOP: BLVRB | |
ligand binding site mutation search in PubMed: BLVRB | ||
UCL Cancer Institute: BLVRB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0042167 | heme catabolic process | 7929092 |
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Ligand binding site mutations for BLVRB |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | V128 | A127S | BRCA | 1 | H132 | R134W | COAD | 1 | H132 | D131N | LUAD | 1 | R174 | P172H | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for BLVRB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H132 | D131N | -1.3838637 | V128 | A127S | -1.3189895 | R174 | P172H | -1.2518224 | H132 | R134W | -1.028904 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for BLVRB from PDB |
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Differential gene expression and gene-gene network for BLVRB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for BLVRB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0279626 | Esophageal Squamous Cell Carcinoma | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for BLVRB |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical|vet_approved | DB00140 | Riboflavin | Small molecule | |
Nutraceutical | DB00157 | NADH | Small molecule | |
Experimental | DB02073 | Biliverdine Ix Alpha | Small molecule | |
Experimental | DB03247 | Riboflavin Monophosphate | Small molecule | |
Experimental | DB03461 | 2'-Monophosphoadenosine 5'-Diphosphoribose | Small molecule | |
Experimental | DB04345 | 7,8-dimethylalloxazine | Small molecule | |
Experimental | DB04363 | Mesobiliverdin Iv Alpha | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of BLVRB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 1hdo | A | H132 | NAP | NADP ZWITTERION | 1he2 | A | H132 | NAP | NADP ZWITTERION | 1he3 | A | H132 | NAP | NADP ZWITTERION | 1he4 | A | H132 | NAP | NADP ZWITTERION | 1he5 | A | H132 | BLA | BILIVERDIN | 1he2 | A | H132 R174 | MBV | MESOBILIVERDIN IV ALPHA | 1he3 | A | H132 R174 | LUM | LUMICHROME | 1he5 | A | V128 H132 |
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Conservation information for LBS of BLVRB |
Multiple alignments for P30043 in multiple species |
LBS | AA sequence | # species | Species | A112 | VACTSAFLLWD | 3 | Homo sapiens, Bos taurus, Mus musculus | C109 | DKVVACTSAFL | 3 | Homo sapiens, Bos taurus, Mus musculus | D54 | HVVVGDVLQAA | 1 | Homo sapiens | D54 | HVVVGDVRQPA | 1 | Bos taurus | D54 | HVVVGDVRQAA | 1 | Mus musculus | D80 | LGTRNDLSPTT | 2 | Homo sapiens, Bos taurus | D80 | LGTGNDLSPTT | 1 | Mus musculus | F113 | ACTSAFLLWDP | 3 | Homo sapiens, Bos taurus, Mus musculus | G10 | KIAIFGATGQT | 1 | Homo sapiens | G10 | KIALFGATGNT | 1 | Bos taurus | G10 | KIAIFGATGRT | 1 | Mus musculus | G13 | IFGATGQTGLT | 1 | Homo sapiens | G13 | LFGATGNTGLT | 1 | Bos taurus | G13 | IFGATGRTGLT | 1 | Mus musculus | G76 | VIVLLGTRNDL | 2 | Homo sapiens, Bos taurus | G76 | VIVLLGTGNDL | 1 | Mus musculus | H132 | DVTDDHIRMHK | 2 | Bos taurus, Mus musculus | H132 | AVTDDHIRMHK | 1 | Homo sapiens | H153 | AVMPPHIGDQP | 2 | Homo sapiens, Mus musculus | H153 | AVMPPHIGDHP | 1 | Bos taurus | I154 | VMPPHIGDQPL | 2 | Homo sapiens, Mus musculus | I154 | VMPPHIGDHPL | 1 | Bos taurus | L125 | KVPPRLQDVTD | 2 | Bos taurus, Mus musculus | L125 | KVPPRLQAVTD | 1 | Homo sapiens | L74 | DAVIVLLGTRN | 2 | Homo sapiens, Bos taurus | L74 | EAVIVLLGTGN | 1 | Mus musculus | L75 | AVIVLLGTRND | 2 | Homo sapiens, Bos taurus | L75 | AVIVLLGTGND | 1 | Mus musculus | L81 | GTRNDLSPTTV | 2 | Homo sapiens, Bos taurus | L81 | GTGNDLSPTTV | 1 | Mus musculus | M87 | SPTTVMSEGAR | 1 | Homo sapiens | M87 | SPTTVMSEGAQ | 1 | Bos taurus | M87 | SPTTVMSEGTR | 1 | Mus musculus | N79 | LLGTRNDLSPT | 2 | Homo sapiens, Bos taurus | N79 | LLGTGNDLSPT | 1 | Mus musculus | P151 | YVAVMPPHIGD | 3 | Homo sapiens, Bos taurus, Mus musculus | P152 | VAVMPPHIGDQ | 2 | Homo sapiens, Mus musculus | P152 | VAVMPPHIGDH | 1 | Bos taurus | Q14 | FGATGQTGLTT | 1 | Homo sapiens | Q14 | FGATGNTGLTT | 1 | Bos taurus | Q14 | FGATGRTGLTT | 1 | Mus musculus | R124 | TKVPPRLQAVT | 1 | Homo sapiens | R124 | SKVPPRLQDVT | 1 | Bos taurus | R124 | TKVPPRLQDVT | 1 | Mus musculus | R174 | GRGPSRVISKH | 3 | Homo sapiens, Bos taurus, Mus musculus | R35 | VTVLVRDSSRL | 2 | Homo sapiens, Mus musculus | R35 | VTVLVRDPSRL | 1 | Bos taurus | R39 | VRDSSRLPSEG | 2 | Homo sapiens, Mus musculus | R39 | VRDPSRLPSEG | 1 | Bos taurus | R78 | VLLGTRNDLSP | 2 | Homo sapiens, Bos taurus | R78 | VLLGTGNDLSP | 1 | Mus musculus | S111 | VVACTSAFLLW | 3 | Homo sapiens, Bos taurus, Mus musculus | T110 | KVVACTSAFLL | 3 | Homo sapiens, Bos taurus, Mus musculus | T12 | AIFGATGQTGL | 1 | Homo sapiens | T12 | ALFGATGNTGL | 1 | Bos taurus | T12 | AIFGATGRTGL | 1 | Mus musculus | T15 | GATGQTGLTTL | 1 | Homo sapiens | T15 | GATGNTGLTTL | 1 | Bos taurus | T15 | GATGRTGLTTL | 1 | Mus musculus | T77 | IVLLGTRNDLS | 2 | Homo sapiens, Bos taurus | T77 | IVLLGTGNDLS | 1 | Mus musculus | V128 | PRLQDVTDDHI | 2 | Bos taurus, Mus musculus | V128 | PRLQAVTDDHI | 1 | Homo sapiens | V55 | VVVGDVLQAAD | 1 | Homo sapiens | V55 | VVVGDVRQPAD | 1 | Bos taurus | V55 | VVVGDVRQAAD | 1 | Mus musculus | V86 | LSPTTVMSEGA | 2 | Homo sapiens, Bos taurus | V86 | LSPTTVMSEGT | 1 | Mus musculus | W116 | SAFLLWDPTKV | 2 | Homo sapiens, Mus musculus | W116 | SAFLLWDPSKV | 1 | Bos taurus |
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