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mutLBSgeneDB |
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| Gene summary for ANAPC1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ANAPC1 |
| Gene name | anaphase promoting complex subunit 1 | |
| Synonyms | APC1|MCPR|TSG24 | |
| Cytomap | UCSC genome browser: 2q12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022662.3, | |
| Description | anaphase-promoting complex 1 (meiotic checkpoint regulator)anaphase-promoting complex subunit 1cyclosome subunit 1mitotic checkpoint regulatortestis-specific gene 24 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608473 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000153107 | ||
| HPRD : 09769 | ||
| Vega : OTTHUMG00000131277 | ||
| Protein | UniProt: Q9H1A4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANAPC1 | |
| BioGPS: 64682 | ||
| Pathway | NCI Pathway Interaction Database: ANAPC1 | |
| KEGG: ANAPC1 | ||
| REACTOME: ANAPC1 | ||
| Pathway Commons: ANAPC1 | ||
| Context | iHOP: ANAPC1 | |
| ligand binding site mutation search in PubMed: ANAPC1 | ||
| UCL Cancer Institute: ANAPC1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
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| Ligand binding site mutations for ANAPC1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M1652 | L1651F | LUSC | 1 | M1652 | A1653V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ANAPC1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M1652 | L1651F | -1.606844 | M1652 | A1653V | -0.73579979 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ANAPC1 from PDB |
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| Differential gene expression and gene-gene network for ANAPC1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ANAPC1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ANAPC1 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ANAPC1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ALA,ALA,ALA,ALA,ALA,GLN,LEU,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA,ALA) | 4ui9 | A | M1652 |
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| Conservation information for LBS of ANAPC1 |
| Multiple alignments for Q9H1A4 in multiple species |
| LBS | AA sequence | # species | Species | E1480 | RFAGSENLSAF | 2 | Homo sapiens, Mus musculus | E1480 | RFAGTRDGNAR | 1 | Arabidopsis thaliana | E1649 | YEQTKEELMAP | 2 | Homo sapiens, Mus musculus | E1649 | YSETKFCEITP | 1 | Arabidopsis thaliana | L1420 | LWDDILPNSKW | 2 | Homo sapiens, Mus musculus | L1420 | MWSRICPTCDW | 1 | Arabidopsis thaliana | L1482 | AGSENLSAFNC | 1 | Homo sapiens | L1482 | AGTRDGNARDL | 1 | Arabidopsis thaliana | L1482 | AGSENLSAFSC | 1 | Mus musculus | M1652 | TKEELMAPTLL | 2 | Homo sapiens, Mus musculus | M1652 | TKFCEITPCIL | 1 | Arabidopsis thaliana | N1320 | GMSDLNVPEQL | 2 | Homo sapiens, Mus musculus | N1320 | GSMD-SLVNRL | 1 | Arabidopsis thaliana | N1481 | FAGSENLSAFN | 1 | Homo sapiens | N1481 | FAGTRDGNARD | 1 | Arabidopsis thaliana | N1481 | FAGSENLSAFS | 1 | Mus musculus | P1322 | SDLNVPEQLYQ | 2 | Homo sapiens, Mus musculus | P1322 | MD-SLVNRLLL | 1 | Arabidopsis thaliana | P1421 | WDDILPNSKWV | 2 | Homo sapiens, Mus musculus | P1421 | WSRICPTCDWI | 1 | Arabidopsis thaliana | S1317 | NLIGMSDLNVP | 2 | Homo sapiens, Mus musculus | S1317 | DALGSMD-SLV | 1 | Arabidopsis thaliana | T1647 | QWYEQTKEELM | 2 | Homo sapiens, Mus musculus | T1647 | KLYSETKFCEI | 1 | Arabidopsis thaliana | W1386 | RSIADWLRAPD | 2 | Homo sapiens, Mus musculus | W1386 | EVIFSKLSIPQ | 1 | Arabidopsis thaliana |
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