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mutLBSgeneDB |
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| Gene summary for MICAL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | MICAL1 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 1 | |
| Synonyms | MICAL|MICAL-1|NICAL | |
| Cytomap | UCSC genome browser: 6q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001159291.1, NM_001286613.1,NM_022765.3, | |
| Description | CasL interacting moleculeNEDD9-interacting protein with calponin homology and LIM domainsmicrotubule associated monoxygenase, calponin and LIM domain containing 1molecule interacting with CasL protein 1protein-methionine sulfoxide oxidase MICAL1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607129 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135596 | ||
| HPRD : 06183 | ||
| Vega : OTTHUMG00000015350 | ||
| Protein | UniProt: Q8TDZ2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MICAL1 | |
| BioGPS: 64780 | ||
| Pathway | NCI Pathway Interaction Database: MICAL1 | |
| KEGG: MICAL1 | ||
| REACTOME: MICAL1 | ||
| Pathway Commons: MICAL1 | ||
| Context | iHOP: MICAL1 | |
| ligand binding site mutation search in PubMed: MICAL1 | ||
| UCL Cancer Institute: MICAL1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0030042 | actin filament depolymerization | 21864500 | GO:0055114 | oxidation-reduction process | 21864500 |
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| Ligand binding site mutations for MICAL1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H718 | F717L | BLCA | 1 | C724 | R723H | COAD | 1 | C697 | D695N | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MICAL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C724 | R723H | -1.1201263 | C697 | D695N | -0.79754715 | H718 | F717L | -0.64086972 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MICAL1 from PDB |
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| Differential gene expression and gene-gene network for MICAL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MICAL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MICAL1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MICAL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of MICAL1 |
| Multiple alignments for Q8TDZ2 in multiple species |
| LBS | AA sequence | # species | Species | C697 | GAGDLCALCGE | 1 | Homo sapiens | C697 | GAEELCELCGK | 1 | Mus musculus | C697 | GAEDVCELCGK | 1 | Rattus norvegicus | C697 | SAEDLCALCGQ | 1 | Bos taurus | C700 | DLCALCGEHLY | 1 | Homo sapiens | C700 | ELCELCGKHLY | 1 | Mus musculus | C700 | DVCELCGKRLY | 1 | Rattus norvegicus | C700 | DLCALCGQHLY | 1 | Bos taurus | C721 | FFHRSCFRCHT | 1 | Homo sapiens | C721 | FFHRSCFCCHT | 1 | Mus musculus | C721 | FFHRGCFCCRT | 1 | Rattus norvegicus | C721 | FFHRSCFRCHI | 1 | Bos taurus | C724 | RSCFRCHTCEA | 1 | Homo sapiens | C724 | RSCFCCHTCEA | 1 | Mus musculus | C724 | RGCFCCRTCEA | 1 | Rattus norvegicus | C724 | RSCFRCHICEA | 1 | Bos taurus | C727 | FRCHTCEATLW | 1 | Homo sapiens | C727 | FCCHTCEATLW | 1 | Mus musculus | C727 | FCCRTCEATLR | 1 | Rattus norvegicus | C727 | FRCHICEATLW | 1 | Bos taurus | C747 | DGHFYCLQHLP | 2 | Homo sapiens, Mus musculus | C747 | DGYFYCLQHLP | 1 | Rattus norvegicus | C747 | DGYLYCLQHLP | 1 | Bos taurus | H718 | NGHFFHRSCFR | 1 | Homo sapiens | H718 | DGHFFHRSCFC | 1 | Mus musculus | H718 | DGHFFHRGCFC | 1 | Rattus norvegicus | H718 | DGRFFHRSCFR | 1 | Bos taurus | H750 | FYCLQHLPQED | 2 | Mus musculus, Rattus norvegicus | H750 | FYCLQHLPQTD | 1 | Homo sapiens | H750 | LYCLQHLPQTG | 1 | Bos taurus |
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