mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MICAL1
Gene summary
Basic gene Info.Gene symbolMICAL1
Gene namemicrotubule associated monooxygenase, calponin and LIM domain containing 1
CytomapUCSC genome browser: 6q21
Type of geneprotein-coding
DescriptionCasL interacting moleculeNEDD9-interacting protein with calponin homology and LIM domainsmicrotubule associated monoxygenase, calponin and LIM domain containing 1molecule interacting with CasL protein 1protein-methionine sulfoxide oxidase MICAL1
Modification date20141207
dbXrefs MIM : 607129
Ensembl : ENSG00000135596
HPRD : 06183
Vega : OTTHUMG00000015350
ProteinUniProt: Q8TDZ2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MICAL1
BioGPS: 64780
PathwayNCI Pathway Interaction Database: MICAL1
Pathway Commons: MICAL1
ContextiHOP: MICAL1
ligand binding site mutation search in PubMed: MICAL1
UCL Cancer Institute: MICAL1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0030042actin filament depolymerization21864500
GO:0055114oxidation-reduction process21864500

Ligand binding site mutations for MICAL1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MICAL1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MICAL1 from PDB

Differential gene expression and gene-gene network for MICAL1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MICAL1 and the right PPI network was created from samples without mutations in the LBS of MICAL1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MICAL1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MICAL1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MICAL1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of MICAL1
Multiple alignments for Q8TDZ2 in multiple species
LBSAA sequence# speciesSpecies
C697GAGDLCALCGE1Homo sapiens
C697GAEELCELCGK1Mus musculus
C697GAEDVCELCGK1Rattus norvegicus
C697SAEDLCALCGQ1Bos taurus
C700DLCALCGEHLY1Homo sapiens
C700ELCELCGKHLY1Mus musculus
C700DVCELCGKRLY1Rattus norvegicus
C700DLCALCGQHLY1Bos taurus
C721FFHRSCFRCHT1Homo sapiens
C721FFHRSCFCCHT1Mus musculus
C721FFHRGCFCCRT1Rattus norvegicus
C721FFHRSCFRCHI1Bos taurus
C724RSCFRCHTCEA1Homo sapiens
C724RSCFCCHTCEA1Mus musculus
C724RGCFCCRTCEA1Rattus norvegicus
C724RSCFRCHICEA1Bos taurus
C727FRCHTCEATLW1Homo sapiens
C727FCCHTCEATLW1Mus musculus
C727FCCRTCEATLR1Rattus norvegicus
C727FRCHICEATLW1Bos taurus
C747DGHFYCLQHLP2Homo sapiens, Mus musculus
C747DGYFYCLQHLP1Rattus norvegicus
C747DGYLYCLQHLP1Bos taurus
H718NGHFFHRSCFR1Homo sapiens
H718DGHFFHRSCFC1Mus musculus
H718DGHFFHRGCFC1Rattus norvegicus
H718DGRFFHRSCFR1Bos taurus
H750FYCLQHLPQED2Mus musculus, Rattus norvegicus
H750FYCLQHLPQTD1Homo sapiens
H750LYCLQHLPQTG1Bos taurus

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