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mutLBSgeneDB |
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| Gene summary for ST6GAL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ST6GAL1 |
| Gene name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | |
| Synonyms | SIAT1|ST6GalI|ST6N | |
| Cytomap | UCSC genome browser: 3q27-q28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003032.2, NM_173216.2,NM_173217.2, | |
| Description | B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6Gal Ialpha 2,6-ST 1beta-galactoside alpha-2,6-sialyltransferase 1sialyltransferase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 109675 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000073849 | ||
| HPRD : 00184 | ||
| Vega : OTTHUMG00000156500 | ||
| Protein | UniProt: P15907 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ST6GAL1 | |
| BioGPS: 6480 | ||
| Pathway | NCI Pathway Interaction Database: ST6GAL1 | |
| KEGG: ST6GAL1 | ||
| REACTOME: ST6GAL1 | ||
| Pathway Commons: ST6GAL1 | ||
| Context | iHOP: ST6GAL1 | |
| ligand binding site mutation search in PubMed: ST6GAL1 | ||
| UCL Cancer Institute: ST6GAL1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006054 | N-acetylneuraminate metabolic process | 23999306 | GO:0018279 | protein N-linked glycosylation via asparagine | 23999306 | GO:0097503 | sialylation | 23999306 |
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| Ligand binding site mutations for ST6GAL1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A190 | G191R | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ST6GAL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A190 | G191R | -0.1065159 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ST6GAL1 from PDB |
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| Differential gene expression and gene-gene network for ST6GAL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ST6GAL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0011860 | Diabetes Mellitus, Type 2 | 1 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ST6GAL1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ST6GAL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CTN | CYTIDINE | 4js1 | A | A190 | C | CMP | 4js2 | A | A190 |
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| Conservation information for LBS of ST6GAL1 |
| Multiple alignments for P15907 in multiple species |
| LBS | AA sequence | # species | Species | A190 | AVVSSAGSLKS | 2 | Homo sapiens, Gallus gallus | A190 | AVVSSAGSLKN | 2 | Mus musculus, Rattus norvegicus | C353 | RKTDVCYYHQK | 2 | Mus musculus, Rattus norvegicus | C353 | RKTDVCYYYQK | 1 | Homo sapiens | C353 | RQTDICHYYQK | 1 | Gallus gallus | C364 | FFDSACTMGAY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C364 | FHDHACTMGAY | 1 | Gallus gallus | F211 | DAVLRFNGAPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F211 | DAVLRFNGAPV | 1 | Gallus gallus | F343 | VDIYEFLPSKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F343 | VDVYEFLPSKR | 1 | Gallus gallus | G324 | NPPSSGMLGII | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G324 | NPPSSGMLGIV | 1 | Gallus gallus | H370 | TMGAYHPLLFE | 2 | Gallus gallus, Mus musculus | H370 | TMGAYHPLLYE | 1 | Homo sapiens | H370 | TMGAYDPLLFE | 1 | Rattus norvegicus | K376 | PLLFEKNMVKH | 2 | Mus musculus, Rattus norvegicus | K376 | PLLYEKNLVKH | 1 | Homo sapiens | K376 | PLLFEKNLVKH | 1 | Gallus gallus | L372 | GAYHPLLFEKN | 2 | Gallus gallus, Mus musculus | L372 | GAYHPLLYEKN | 1 | Homo sapiens | L372 | GAYDPLLFEKN | 1 | Rattus norvegicus | N212 | AVLRFNGAPTD | 2 | Mus musculus, Rattus norvegicus | N212 | AVLRFNGAPTA | 1 | Homo sapiens | N212 | AVLRFNGAPVK | 1 | Gallus gallus | N233 | TIRLMNSQLVT | 2 | Homo sapiens, Rattus norvegicus | N233 | TIRLVNSQLVT | 2 | Gallus gallus, Mus musculus | S188 | RCAVVSSAGSL | 3 | Homo sapiens, Gallus gallus, Rattus norvegicus | S188 | KCAVVSSAGSL | 1 | Mus musculus | S189 | CAVVSSAGSLK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | S322 | QPNPPSSGMLG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | S323 | PNPPSSGMLGI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | T365 | FDSACTMGAYH | 2 | Homo sapiens, Mus musculus | T365 | HDHACTMGAYH | 1 | Gallus gallus | T365 | FDSACTMGAYD | 1 | Rattus norvegicus | Y354 | KTDVCYYHQKF | 2 | Mus musculus, Rattus norvegicus | Y354 | KTDVCYYYQKF | 1 | Homo sapiens | Y354 | QTDICHYYQKF | 1 | Gallus gallus |
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