mutLBSgeneDB |
Gene summary for PAPOLG |
Gene summary |
Basic gene Info. | Gene symbol | PAPOLG |
Gene name | poly(A) polymerase gamma | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p16.1 | |
Type of gene | protein-coding | |
RefGenes | NM_022894.3, | |
Description | PAP-gammaSRP RNA 3' adenylating enzyme/pap2SRP RNA 3'-adenylating enzymeneo-PAPneo-poly(A) polymerasenuclear poly(A) polymerase gammapolynucleotide adenylyltransferase gamma | |
Modification date | 20141215 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000115421 | ||
HPRD : 11420 | ||
Vega : OTTHUMG00000129419 | ||
Protein | UniProt: Q9BWT3 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PAPOLG | |
BioGPS: 64895 | ||
Pathway | NCI Pathway Interaction Database: PAPOLG | |
KEGG: PAPOLG | ||
REACTOME: PAPOLG | ||
Pathway Commons: PAPOLG | ||
Context | iHOP: PAPOLG | |
ligand binding site mutation search in PubMed: PAPOLG | ||
UCL Cancer Institute: PAPOLG | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0043631 | RNA polyadenylation | 11287430 |
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Ligand binding site mutations for PAPOLG |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S324 | S324Y | COAD | 1 | Y236 | N238S | UCEC | 1 | S324 | T325M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PAPOLG |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S324 | T325M | -1.3192252 | S324 | S324Y | -0.19368585 | Y236 | N238S | -0.13966897 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PAPOLG from PDB |
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Differential gene expression and gene-gene network for PAPOLG |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for PAPOLG |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PAPOLG |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PAPOLG go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 3AT | CORDYCEPIN TRIPHOSPHATE | 4lt6 | A | Y236 S324 | 3AT | CORDYCEPIN TRIPHOSPHATE | 4lt6 | B | Y236 S324 |
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Conservation information for LBS of PAPOLG |
Multiple alignments for Q9BWT3 in multiple species |
LBS | AA sequence | # species | Species | D112 | HTKGADIDALC | 2 | Homo sapiens, Mus musculus | D112 | HGPGADIDTLC | 1 | Arabidopsis thaliana | D112 | HGPGSDIDTLV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D112 | YGPGSDIDTLV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D114 | KGADIDALCVA | 2 | Homo sapiens, Mus musculus | D114 | PGSDIDTLVVV | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D114 | PGADIDTLCVG | 1 | Arabidopsis thaliana | F99 | GKIFTFGSYRL | 2 | Homo sapiens, Mus musculus | F99 | GKIFTYGSYRL | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F99 | AKIFTFGSYRL | 1 | Arabidopsis thaliana | G100 | KIFTFGSYRLG | 3 | Homo sapiens, Mus musculus, Arabidopsis thaliana | G100 | KIFTYGSYRLG | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K227 | TLRAVKLWAKR | 2 | Homo sapiens, Mus musculus | K227 | TLRCMRFWAKR | 1 | Arabidopsis thaliana | K227 | ALRAIKLWAQR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K227 | ALRAIKFWAQR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N201 | CIRSLNGCRVT | 2 | Homo sapiens, Mus musculus | N201 | TVRSLNGCRVT | 1 | Arabidopsis thaliana | N201 | DLRALNGTRVT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N201 | CVLSLNGTRVT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S101 | IFTFGSYRLGV | 3 | Homo sapiens, Mus musculus, Arabidopsis thaliana | S101 | IFTYGSYRLGV | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S324 | YPQQNSTYNVS | 2 | Homo sapiens, Mus musculus | S324 | YPSMCATHNIT | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S324 | YPCMNSSYNVS | 1 | Arabidopsis thaliana | V205 | LNGCRVTDEIL | 2 | Homo sapiens, Mus musculus | V205 | LNGCRVTDQIL | 1 | Arabidopsis thaliana | V205 | LNGTRVTDEIL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V205 | LNGTRVTDQIL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V246 | GFLGGVSWAML | 2 | Homo sapiens, Mus musculus | V246 | GFLGGINWALL | 1 | Arabidopsis thaliana | V246 | GFPGGVAWAML | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V246 | GFPGGVAWAMM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y236 | KRRGIYSNMLG | 2 | Homo sapiens, Mus musculus | Y236 | KRRGVYSNVSG | 1 | Arabidopsis thaliana | Y236 | QRRAVYANIFG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y236 | QRRAIYANVVG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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