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mutLBSgeneDB |
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| Gene summary for MRPL14 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL14 |
| Gene name | mitochondrial ribosomal protein L14 | |
| Synonyms | L14mt|L32mt|MRP-L14|MRP-L32|MRPL32|RMPL32|RPML32 | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032111.2, | |
| Description | 39S ribosomal protein L14, mitochondrial39S ribosomal protein L32, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611827 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000180992 | ||
| HPRD : 14741 | ||
| Vega : OTTHUMG00000014756 | ||
| Protein | UniProt: Q6P1L8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL14 | |
| BioGPS: 64928 | ||
| Pathway | NCI Pathway Interaction Database: MRPL14 | |
| KEGG: MRPL14 | ||
| REACTOME: MRPL14 | ||
| Pathway Commons: MRPL14 | ||
| Context | iHOP: MRPL14 | |
| ligand binding site mutation search in PubMed: MRPL14 | ||
| UCL Cancer Institute: MRPL14 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL14 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R37 | R39Q | COAD | 1 | K81 | G79A | LUAD | 1 | R37 | R37L | LUAD | 1 | H59 | H59N | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL14 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R37 | R39Q | -1.4245622 | K81 | G79A | -0.62716222 | H59 | H59N | -0.56147734 | R37 | R37L | -0.49129195 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL14 from PDB |
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| Differential gene expression and gene-gene network for MRPL14 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL14 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL14 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL14 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | L | R37 H59 K81 |
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| Conservation information for LBS of MRPL14 |
| Multiple alignments for Q6P1L8 in multiple species |
| LBS | AA sequence | # species | Species | A31 | TGSLSAIQKMT | 1 | Homo sapiens | A31 | SSAVSAIQKLT | 1 | Danio rerio | A31 | SGSLSAVQKMT | 1 | Mus musculus | A31 | SGSLSAIQKMT | 1 | Rattus norvegicus | A31 | TGSLGAIQKMT | 1 | Bos taurus | C90 | LIVGHRMPGSR | 2 | Mus musculus, Rattus norvegicus | C90 | LIVGHCMPGPR | 1 | Homo sapiens | C90 | IIVGHKMPGAR | 1 | Danio rerio | C90 | LIVGHRMPGPT | 1 | Bos taurus | H52 | GNTPYHRPPRC | 2 | Rattus norvegicus, Bos taurus | H52 | GNSPYHRAPRC | 1 | Homo sapiens | H52 | GNAHHHRPPKV | 1 | Danio rerio | H52 | GSTPYHRPPRC | 1 | Mus musculus | H59 | PPRCIHVYNKS | 2 | Mus musculus, Rattus norvegicus | H59 | APRCIHVYKKN | 1 | Homo sapiens | H59 | PPKVIHVYNKN | 1 | Danio rerio | H59 | PPRCIHVYNKN | 1 | Bos taurus | I58 | RPPRCIHVYNK | 3 | Mus musculus, Rattus norvegicus, Bos taurus | I58 | RAPRCIHVYKK | 1 | Homo sapiens | I58 | RPPKVIHVYNK | 1 | Danio rerio | K34 | LSAIQKMTRVR | 2 | Homo sapiens, Rattus norvegicus | K34 | VSAIQKLTRVR | 1 | Danio rerio | K34 | LSAVQKMTRVR | 1 | Mus musculus | K34 | LGAIQKMTRVR | 1 | Bos taurus | K63 | IHVYNKNGVGK | 2 | Danio rerio, Bos taurus | K63 | IHVYNKSGVGK | 2 | Mus musculus, Rattus norvegicus | K63 | IHVYKKNGVGK | 1 | Homo sapiens | K81 | AIKGQKKKALI | 2 | Homo sapiens, Bos taurus | K81 | AIRGQKKKALI | 2 | Mus musculus, Rattus norvegicus | K81 | AIKGQKKKAII | 1 | Danio rerio | L74 | VGDQILLAIRG | 2 | Mus musculus, Rattus norvegicus | L74 | VGDQILLAIKG | 1 | Homo sapiens | L74 | VGDRVLLAIKG | 1 | Danio rerio | L74 | VGDRILLAIKG | 1 | Bos taurus | M35 | SAIQKMTRVRV | 2 | Homo sapiens, Rattus norvegicus | M35 | SAIQKLTRVRV | 1 | Danio rerio | M35 | SAVQKMTRVRV | 1 | Mus musculus | M35 | GAIQKMTRVRV | 1 | Bos taurus | M91 | IVGHRMPGSRM | 2 | Mus musculus, Rattus norvegicus | M91 | IVGHCMPGPRM | 1 | Homo sapiens | M91 | IVGHKMPGARM | 1 | Danio rerio | M91 | IVGHRMPGPTM | 1 | Bos taurus | N103 | PRFDSNNVVLI | 3 | Homo sapiens, Danio rerio, Bos taurus | N103 | PKFDSNNVVLI | 2 | Mus musculus, Rattus norvegicus | N64 | HVYNKNGVGKV | 2 | Danio rerio, Bos taurus | N64 | HVYNKSGVGKV | 2 | Mus musculus, Rattus norvegicus | N64 | HVYKKNGVGKV | 1 | Homo sapiens | P92 | VGHRMPGSRMT | 2 | Mus musculus, Rattus norvegicus | P92 | VGHCMPGPRMT | 1 | Homo sapiens | P92 | VGHKMPGARMT | 1 | Danio rerio | P92 | VGHRMPGPTMT | 1 | Bos taurus | Q33 | SLSAIQKMTRV | 2 | Homo sapiens, Rattus norvegicus | Q33 | AVSAIQKLTRV | 1 | Danio rerio | Q33 | SLSAVQKMTRV | 1 | Mus musculus | Q33 | SLGAIQKMTRV | 1 | Bos taurus | R37 | IQKMTRVRVVD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R37 | IQKLTRVRVVD | 1 | Danio rerio | R37 | VQKMTRVRVVD | 1 | Mus musculus | R53 | NTPYHRPPRCI | 2 | Rattus norvegicus, Bos taurus | R53 | NSPYHRAPRCI | 1 | Homo sapiens | R53 | NAHHHRPPKVI | 1 | Danio rerio | R53 | STPYHRPPRCI | 1 | Mus musculus | R56 | YHRPPRCIHVY | 3 | Mus musculus, Rattus norvegicus, Bos taurus | R56 | YHRAPRCIHVY | 1 | Homo sapiens | R56 | HHRPPKVIHVY | 1 | Danio rerio | R95 | RMPGSRMTPKF | 2 | Mus musculus, Rattus norvegicus | R95 | CMPGPRMTPRF | 1 | Homo sapiens | R95 | KMPGARMTPRF | 1 | Danio rerio | R95 | RMPGPTMTPRF | 1 | Bos taurus | T36 | AIQKMTRVRVV | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T36 | AIQKLTRVRVV | 1 | Danio rerio | T36 | AVQKMTRVRVV | 1 | Mus musculus | Y61 | RCIHVYNKSGV | 2 | Mus musculus, Rattus norvegicus | Y61 | RCIHVYKKNGV | 1 | Homo sapiens | Y61 | KVIHVYNKNGV | 1 | Danio rerio | Y61 | RCIHVYNKNGV | 1 | Bos taurus |
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