mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL14
Gene summary
Basic gene Info.Gene symbolMRPL14
Gene namemitochondrial ribosomal protein L14
SynonymsL14mt|L32mt|MRP-L14|MRP-L32|MRPL32|RMPL32|RPML32
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
RefGenesNM_032111.2,
Description39S ribosomal protein L14, mitochondrial39S ribosomal protein L32, mitochondrial
Modification date20141207
dbXrefs MIM : 611827
HGNC : HGNC
Ensembl : ENSG00000180992
HPRD : 14741
Vega : OTTHUMG00000014756
ProteinUniProt: Q6P1L8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL14
BioGPS: 64928
PathwayNCI Pathway Interaction Database: MRPL14
KEGG: MRPL14
REACTOME: MRPL14
Pathway Commons: MRPL14
ContextiHOP: MRPL14
ligand binding site mutation search in PubMed: MRPL14
UCL Cancer Institute: MRPL14
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL14

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R37R39QCOAD1
K81G79ALUAD1
R37R37LLUAD1
H59H59NOV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL14
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R37R39Q-1.4245622
K81G79A-0.62716222
H59H59N-0.56147734
R37R37L-0.49129195
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL14 from PDB

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Differential gene expression and gene-gene network for MRPL14
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL14 and the right PPI network was created from samples without mutations in the LBS of MRPL14. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL14
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL14
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL14 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yLR37 H59 K81


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Conservation information for LBS of MRPL14
Multiple alignments for Q6P1L8 in multiple species
LBSAA sequence# speciesSpecies
A31TGSLSAIQKMT1Homo sapiens
A31SSAVSAIQKLT1Danio rerio
A31SGSLSAVQKMT1Mus musculus
A31SGSLSAIQKMT1Rattus norvegicus
A31TGSLGAIQKMT1Bos taurus
C90LIVGHRMPGSR2Mus musculus, Rattus norvegicus
C90LIVGHCMPGPR1Homo sapiens
C90IIVGHKMPGAR1Danio rerio
C90LIVGHRMPGPT1Bos taurus
H52GNTPYHRPPRC2Rattus norvegicus, Bos taurus
H52GNSPYHRAPRC1Homo sapiens
H52GNAHHHRPPKV1Danio rerio
H52GSTPYHRPPRC1Mus musculus
H59PPRCIHVYNKS2Mus musculus, Rattus norvegicus
H59APRCIHVYKKN1Homo sapiens
H59PPKVIHVYNKN1Danio rerio
H59PPRCIHVYNKN1Bos taurus
I58RPPRCIHVYNK3Mus musculus, Rattus norvegicus, Bos taurus
I58RAPRCIHVYKK1Homo sapiens
I58RPPKVIHVYNK1Danio rerio
K34LSAIQKMTRVR2Homo sapiens, Rattus norvegicus
K34VSAIQKLTRVR1Danio rerio
K34LSAVQKMTRVR1Mus musculus
K34LGAIQKMTRVR1Bos taurus
K63IHVYNKNGVGK2Danio rerio, Bos taurus
K63IHVYNKSGVGK2Mus musculus, Rattus norvegicus
K63IHVYKKNGVGK1Homo sapiens
K81AIKGQKKKALI2Homo sapiens, Bos taurus
K81AIRGQKKKALI2Mus musculus, Rattus norvegicus
K81AIKGQKKKAII1Danio rerio
L74VGDQILLAIRG2Mus musculus, Rattus norvegicus
L74VGDQILLAIKG1Homo sapiens
L74VGDRVLLAIKG1Danio rerio
L74VGDRILLAIKG1Bos taurus
M35SAIQKMTRVRV2Homo sapiens, Rattus norvegicus
M35SAIQKLTRVRV1Danio rerio
M35SAVQKMTRVRV1Mus musculus
M35GAIQKMTRVRV1Bos taurus
M91IVGHRMPGSRM2Mus musculus, Rattus norvegicus
M91IVGHCMPGPRM1Homo sapiens
M91IVGHKMPGARM1Danio rerio
M91IVGHRMPGPTM1Bos taurus
N103PRFDSNNVVLI3Homo sapiens, Danio rerio, Bos taurus
N103PKFDSNNVVLI2Mus musculus, Rattus norvegicus
N64HVYNKNGVGKV2Danio rerio, Bos taurus
N64HVYNKSGVGKV2Mus musculus, Rattus norvegicus
N64HVYKKNGVGKV1Homo sapiens
P92VGHRMPGSRMT2Mus musculus, Rattus norvegicus
P92VGHCMPGPRMT1Homo sapiens
P92VGHKMPGARMT1Danio rerio
P92VGHRMPGPTMT1Bos taurus
Q33SLSAIQKMTRV2Homo sapiens, Rattus norvegicus
Q33AVSAIQKLTRV1Danio rerio
Q33SLSAVQKMTRV1Mus musculus
Q33SLGAIQKMTRV1Bos taurus
R37IQKMTRVRVVD3Homo sapiens, Rattus norvegicus, Bos taurus
R37IQKLTRVRVVD1Danio rerio
R37VQKMTRVRVVD1Mus musculus
R53NTPYHRPPRCI2Rattus norvegicus, Bos taurus
R53NSPYHRAPRCI1Homo sapiens
R53NAHHHRPPKVI1Danio rerio
R53STPYHRPPRCI1Mus musculus
R56YHRPPRCIHVY3Mus musculus, Rattus norvegicus, Bos taurus
R56YHRAPRCIHVY1Homo sapiens
R56HHRPPKVIHVY1Danio rerio
R95RMPGSRMTPKF2Mus musculus, Rattus norvegicus
R95CMPGPRMTPRF1Homo sapiens
R95KMPGARMTPRF1Danio rerio
R95RMPGPTMTPRF1Bos taurus
T36AIQKMTRVRVV3Homo sapiens, Rattus norvegicus, Bos taurus
T36AIQKLTRVRVV1Danio rerio
T36AVQKMTRVRVV1Mus musculus
Y61RCIHVYNKSGV2Mus musculus, Rattus norvegicus
Y61RCIHVYKKNGV1Homo sapiens
Y61KVIHVYNKNGV1Danio rerio
Y61RCIHVYNKNGV1Bos taurus


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