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mutLBSgeneDB |
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| Gene summary for MRPL38 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL38 |
| Gene name | mitochondrial ribosomal protein L38 | |
| Synonyms | L38MT|MRP-L3|MRP-L38|RPML3 | |
| Cytomap | UCSC genome browser: 17q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032478.3, | |
| Description | 39S ribosomal protein L38, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611844 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204316 | ||
| HPRD : 14758 | ||
| Vega : OTTHUMG00000152977 | ||
| Protein | UniProt: Q96DV4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL38 | |
| BioGPS: 64978 | ||
| Pathway | NCI Pathway Interaction Database: MRPL38 | |
| KEGG: MRPL38 | ||
| REACTOME: MRPL38 | ||
| Pathway Commons: MRPL38 | ||
| Context | iHOP: MRPL38 | |
| ligand binding site mutation search in PubMed: MRPL38 | ||
| UCL Cancer Institute: MRPL38 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL38 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R360 | R360L | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL38 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R360 | R360L | -0.044567774 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL38 from PDB |
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| Differential gene expression and gene-gene network for MRPL38 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL38 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL38 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL38 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | 6 | R360 |
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| Conservation information for LBS of MRPL38 |
| Multiple alignments for Q96DV4 in multiple species |
| LBS | AA sequence | # species | Species | F357 | PKQKRFPHRQP | 1 | Homo sapiens | F357 | PKQKCFPHRQP | 1 | Bos taurus | F357 | PKQKRFPHEQP | 1 | Mus musculus | F357 | PKQKRFPHQQP | 1 | Rattus norvegicus | G378 | HEPTYGIY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G378 | HEPTYGFY | 1 | Bos taurus | H351 | RPPPYHPKQKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H351 | RPPPYHPKQKC | 1 | Bos taurus | H359 | QKRFPHRQPLR | 1 | Homo sapiens | H359 | QKCFPHRQPLR | 1 | Bos taurus | H359 | QKRFPHEQPLR | 1 | Mus musculus | H359 | QKRFPHQQPLR | 1 | Rattus norvegicus | I379 | EPTYGIY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I379 | EPTYGFY | 1 | Bos taurus | P352 | PPPYHPKQKRF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P352 | PPPYHPKQKCF | 1 | Bos taurus | R27 | SAVLGRRTPPL | 1 | Homo sapiens | R27 | SAALSRRAAPL | 1 | Bos taurus | R27 | SAFLSRRTPPL | 1 | Mus musculus | R27 | SASLSRRTPPL | 1 | Rattus norvegicus | R28 | AVLGRRTPPLG | 1 | Homo sapiens | R28 | AALSRRAAPLG | 1 | Bos taurus | R28 | AFLSRRTPPLG | 1 | Mus musculus | R28 | ASLSRRTPPLG | 1 | Rattus norvegicus | R356 | HPKQKRFPHRQ | 1 | Homo sapiens | R356 | HPKQKCFPHRQ | 1 | Bos taurus | R356 | HPKQKRFPHEQ | 1 | Mus musculus | R356 | HPKQKRFPHQQ | 1 | Rattus norvegicus | R360 | KRFPHRQPLRY | 1 | Homo sapiens | R360 | KCFPHRQPLRY | 1 | Bos taurus | R360 | KRFPHEQPLRY | 1 | Mus musculus | R360 | KRFPHQQPLRY | 1 | Rattus norvegicus | R364 | HRQPLRYLDRY | 2 | Homo sapiens, Bos taurus | R364 | HEQPLRYLDRY | 1 | Mus musculus | R364 | HQQPLRYLDRY | 1 | Rattus norvegicus | R368 | LRYLDRYRDSH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R52 | RLEKYRSFERY | 2 | Mus musculus, Rattus norvegicus | R52 | RLEKYRSFDRY | 1 | Homo sapiens | R52 | RLKKYRSFDRY | 1 | Bos taurus | R56 | YRSFDRYRRRA | 2 | Homo sapiens, Bos taurus | R56 | YRSFERYRRRA | 2 | Mus musculus, Rattus norvegicus | R59 | FERYRRRAEQE | 2 | Mus musculus, Rattus norvegicus | R59 | FDRYRRRAEQE | 1 | Homo sapiens | R59 | FDRYRRRAERE | 1 | Bos taurus | S53 | LEKYRSFERYR | 2 | Mus musculus, Rattus norvegicus | S53 | LEKYRSFDRYR | 1 | Homo sapiens | S53 | LKKYRSFDRYR | 1 | Bos taurus | T376 | DSHEPTYGIY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T376 | DSHEPTYGFY | 1 | Bos taurus | Y51 | ERLEKYRSFER | 2 | Mus musculus, Rattus norvegicus | Y51 | ERLEKYRSFDR | 1 | Homo sapiens | Y51 | ERLKKYRSFDR | 1 | Bos taurus |
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