mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL36
Gene summary
Basic gene Info.Gene symbolMRPL36
Gene namemitochondrial ribosomal protein L36
CytomapUCSC genome browser: 5p15.3
Type of geneprotein-coding
Description39S ribosomal protein L36, mitochondrialBRCA1-interacting protein 1putative BRCA1-interacting protein
Modification date20141207
dbXrefs MIM : 611842
Ensembl : ENSG00000171421
HPRD : 14756
Vega : OTTHUMG00000090373
ProteinUniProt: Q9P0J6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL36
BioGPS: 64979
PathwayNCI Pathway Interaction Database: MRPL36
Pathway Commons: MRPL36
ContextiHOP: MRPL36
ligand binding site mutation search in PubMed: MRPL36
UCL Cancer Institute: MRPL36
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MRPL36

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MRPL36
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL36 from PDB

Differential gene expression and gene-gene network for MRPL36
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL36 and the right PPI network was created from samples without mutations in the LBS of MRPL36. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MRPL36
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MRPL36
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL36 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7y4V71

Conservation information for LBS of MRPL36
Multiple alignments for Q9P0J6 in multiple species
LBSAA sequence# speciesSpecies
C76VIKKRCRDCYM2Rattus norvegicus, Rattus norvegicus
C76VLKKRCKDCYL1Homo sapiens
C76VIKKRCKDCYK1Mus musculus
C79KRCRDCYMVKR2Rattus norvegicus, Rattus norvegicus
C79KRCKDCYLVKR1Homo sapiens
C79KRCKDCYKVKR1Mus musculus
C92RWFVLCKTNPK2Rattus norvegicus, Rattus norvegicus
C92RWYVYCKTHPR1Homo sapiens
C92RWFILCKTNPK1Mus musculus
G86MVKRRGRWFVL2Rattus norvegicus, Rattus norvegicus
G86LVKRRGRWYVY1Homo sapiens
G86KVKRRGRWFIL1Mus musculus
H98KTNPKHKQRQM3Mus musculus, Rattus norvegicus, Rattus norvegicus
H98KTHPRHKQRQM1Homo sapiens
K67PSLGFKTKGVI3Mus musculus, Rattus norvegicus, Rattus norvegicus
K67PALGFKNKTVL1Homo sapiens
K69LGFKTKGVIKK3Mus musculus, Rattus norvegicus, Rattus norvegicus
K69LGFKNKTVLKK1Homo sapiens
K74KGVIKKRCRDC2Rattus norvegicus, Rattus norvegicus
K74KTVLKKRCKDC1Homo sapiens
K74KGVIKKRCKDC1Mus musculus
K77IKKRCRDCYMV2Rattus norvegicus, Rattus norvegicus
K77LKKRCKDCYLV1Homo sapiens
K77IKKRCKDCYKV1Mus musculus
K83DCYMVKRRGRW2Rattus norvegicus, Rattus norvegicus
K83DCYLVKRRGRW1Homo sapiens
K83DCYKVKRRGRW1Mus musculus
K99TNPKHKQRQM3Mus musculus, Rattus norvegicus, Rattus norvegicus
K99THPRHKQRQM1Homo sapiens
L81CRDCYMVKRRG2Rattus norvegicus, Rattus norvegicus
L81CKDCYLVKRRG1Homo sapiens
L81CKDCYKVKRRG1Mus musculus
N68SLGFKTKGVIK3Mus musculus, Rattus norvegicus, Rattus norvegicus
N68ALGFKNKTVLK1Homo sapiens
P96LCKTNPKHKQR3Mus musculus, Rattus norvegicus, Rattus norvegicus
P96YCKTHPRHKQR1Homo sapiens
Q100NPKHKQRQM3Mus musculus, Rattus norvegicus, Rattus norvegicus
Q100HPRHKQRQM1Homo sapiens
R101PKHKQRQM3Mus musculus, Rattus norvegicus, Rattus norvegicus
R101PRHKQRQM1Homo sapiens
R75GVIKKRCRDCY2Rattus norvegicus, Rattus norvegicus
R75TVLKKRCKDCY1Homo sapiens
R75GVIKKRCKDCY1Mus musculus
R84CYMVKRRGRWF2Rattus norvegicus, Rattus norvegicus
R84CYLVKRRGRWY1Homo sapiens
R84CYKVKRRGRWF1Mus musculus
R85YMVKRRGRWFV2Rattus norvegicus, Rattus norvegicus
R85YLVKRRGRWYV1Homo sapiens
R85YKVKRRGRWFI1Mus musculus
R87VKRRGRWFVLC2Rattus norvegicus, Rattus norvegicus
R87VKRRGRWYVYC1Homo sapiens
R87VKRRGRWFILC1Mus musculus
R97CKTNPKHKQRQ3Mus musculus, Rattus norvegicus, Rattus norvegicus
R97CKTHPRHKQRQ1Homo sapiens
T70GFKTKGVIKKR3Mus musculus, Rattus norvegicus, Rattus norvegicus
T70GFKNKTVLKKR1Homo sapiens
V71FKTKGVIKKRC3Mus musculus, Rattus norvegicus, Rattus norvegicus
V71FKNKTVLKKRC1Homo sapiens
V82RDCYMVKRRGR2Rattus norvegicus, Rattus norvegicus
V82KDCYLVKRRGR1Homo sapiens
V82KDCYKVKRRGR1Mus musculus
W88KRRGRWFVLCK2Rattus norvegicus, Rattus norvegicus
W88KRRGRWYVYCK1Homo sapiens
W88KRRGRWFILCK1Mus musculus
Y89RRGRWFVLCKT2Rattus norvegicus, Rattus norvegicus
Y89RRGRWYVYCKT1Homo sapiens
Y89RRGRWFILCKT1Mus musculus
Y91GRWFVLCKTNP2Rattus norvegicus, Rattus norvegicus
Y91GRWYVYCKTHP1Homo sapiens
Y91GRWFILCKTNP1Mus musculus

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