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mutLBSgeneDB |
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| Gene summary for MRPL36 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL36 |
| Gene name | mitochondrial ribosomal protein L36 | |
| Synonyms | BRIP1|L36mt|MRP-L36|PRPL36|RPMJ | |
| Cytomap | UCSC genome browser: 5p15.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032479.3, | |
| Description | 39S ribosomal protein L36, mitochondrialBRCA1-interacting protein 1putative BRCA1-interacting protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611842 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171421 | ||
| HPRD : 14756 | ||
| Vega : OTTHUMG00000090373 | ||
| Protein | UniProt: Q9P0J6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL36 | |
| BioGPS: 64979 | ||
| Pathway | NCI Pathway Interaction Database: MRPL36 | |
| KEGG: MRPL36 | ||
| REACTOME: MRPL36 | ||
| Pathway Commons: MRPL36 | ||
| Context | iHOP: MRPL36 | |
| ligand binding site mutation search in PubMed: MRPL36 | ||
| UCL Cancer Institute: MRPL36 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL36 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V71 | V71A | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL36 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V71 | V71A | -1.6239038 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL36 from PDB |
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| Differential gene expression and gene-gene network for MRPL36 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL36 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL36 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL36 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | 4 | V71 |
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| Conservation information for LBS of MRPL36 |
| Multiple alignments for Q9P0J6 in multiple species |
| LBS | AA sequence | # species | Species | C76 | VIKKRCRDCYM | 2 | Rattus norvegicus, Rattus norvegicus | C76 | VLKKRCKDCYL | 1 | Homo sapiens | C76 | VIKKRCKDCYK | 1 | Mus musculus | C79 | KRCRDCYMVKR | 2 | Rattus norvegicus, Rattus norvegicus | C79 | KRCKDCYLVKR | 1 | Homo sapiens | C79 | KRCKDCYKVKR | 1 | Mus musculus | C92 | RWFVLCKTNPK | 2 | Rattus norvegicus, Rattus norvegicus | C92 | RWYVYCKTHPR | 1 | Homo sapiens | C92 | RWFILCKTNPK | 1 | Mus musculus | G86 | MVKRRGRWFVL | 2 | Rattus norvegicus, Rattus norvegicus | G86 | LVKRRGRWYVY | 1 | Homo sapiens | G86 | KVKRRGRWFIL | 1 | Mus musculus | H98 | KTNPKHKQRQM | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | H98 | KTHPRHKQRQM | 1 | Homo sapiens | K67 | PSLGFKTKGVI | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | K67 | PALGFKNKTVL | 1 | Homo sapiens | K69 | LGFKTKGVIKK | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | K69 | LGFKNKTVLKK | 1 | Homo sapiens | K74 | KGVIKKRCRDC | 2 | Rattus norvegicus, Rattus norvegicus | K74 | KTVLKKRCKDC | 1 | Homo sapiens | K74 | KGVIKKRCKDC | 1 | Mus musculus | K77 | IKKRCRDCYMV | 2 | Rattus norvegicus, Rattus norvegicus | K77 | LKKRCKDCYLV | 1 | Homo sapiens | K77 | IKKRCKDCYKV | 1 | Mus musculus | K83 | DCYMVKRRGRW | 2 | Rattus norvegicus, Rattus norvegicus | K83 | DCYLVKRRGRW | 1 | Homo sapiens | K83 | DCYKVKRRGRW | 1 | Mus musculus | K99 | TNPKHKQRQM | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | K99 | THPRHKQRQM | 1 | Homo sapiens | L81 | CRDCYMVKRRG | 2 | Rattus norvegicus, Rattus norvegicus | L81 | CKDCYLVKRRG | 1 | Homo sapiens | L81 | CKDCYKVKRRG | 1 | Mus musculus | N68 | SLGFKTKGVIK | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | N68 | ALGFKNKTVLK | 1 | Homo sapiens | P96 | LCKTNPKHKQR | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | P96 | YCKTHPRHKQR | 1 | Homo sapiens | Q100 | NPKHKQRQM | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | Q100 | HPRHKQRQM | 1 | Homo sapiens | R101 | PKHKQRQM | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | R101 | PRHKQRQM | 1 | Homo sapiens | R75 | GVIKKRCRDCY | 2 | Rattus norvegicus, Rattus norvegicus | R75 | TVLKKRCKDCY | 1 | Homo sapiens | R75 | GVIKKRCKDCY | 1 | Mus musculus | R84 | CYMVKRRGRWF | 2 | Rattus norvegicus, Rattus norvegicus | R84 | CYLVKRRGRWY | 1 | Homo sapiens | R84 | CYKVKRRGRWF | 1 | Mus musculus | R85 | YMVKRRGRWFV | 2 | Rattus norvegicus, Rattus norvegicus | R85 | YLVKRRGRWYV | 1 | Homo sapiens | R85 | YKVKRRGRWFI | 1 | Mus musculus | R87 | VKRRGRWFVLC | 2 | Rattus norvegicus, Rattus norvegicus | R87 | VKRRGRWYVYC | 1 | Homo sapiens | R87 | VKRRGRWFILC | 1 | Mus musculus | R97 | CKTNPKHKQRQ | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | R97 | CKTHPRHKQRQ | 1 | Homo sapiens | T70 | GFKTKGVIKKR | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | T70 | GFKNKTVLKKR | 1 | Homo sapiens | V71 | FKTKGVIKKRC | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | V71 | FKNKTVLKKRC | 1 | Homo sapiens | V82 | RDCYMVKRRGR | 2 | Rattus norvegicus, Rattus norvegicus | V82 | KDCYLVKRRGR | 1 | Homo sapiens | V82 | KDCYKVKRRGR | 1 | Mus musculus | W88 | KRRGRWFVLCK | 2 | Rattus norvegicus, Rattus norvegicus | W88 | KRRGRWYVYCK | 1 | Homo sapiens | W88 | KRRGRWFILCK | 1 | Mus musculus | Y89 | RRGRWFVLCKT | 2 | Rattus norvegicus, Rattus norvegicus | Y89 | RRGRWYVYCKT | 1 | Homo sapiens | Y89 | RRGRWFILCKT | 1 | Mus musculus | Y91 | GRWFVLCKTNP | 2 | Rattus norvegicus, Rattus norvegicus | Y91 | GRWYVYCKTHP | 1 | Homo sapiens | Y91 | GRWFILCKTNP | 1 | Mus musculus |
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