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mutLBSgeneDB |
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| Gene summary for MRPL32 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL32 |
| Gene name | mitochondrial ribosomal protein L32 | |
| Synonyms | L32mt|MRP-L32|bMRP-59b | |
| Cytomap | UCSC genome browser: 7p14 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031903.2, | |
| Description | 39S ribosomal protein L32, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611839 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106591 | ||
| HPRD : 14752 | ||
| Vega : OTTHUMG00000155180 | ||
| Protein | UniProt: Q9BYC8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL32 | |
| BioGPS: 64983 | ||
| Pathway | NCI Pathway Interaction Database: MRPL32 | |
| KEGG: MRPL32 | ||
| REACTOME: MRPL32 | ||
| Pathway Commons: MRPL32 | ||
| Context | iHOP: MRPL32 | |
| ligand binding site mutation search in PubMed: MRPL32 | ||
| UCL Cancer Institute: MRPL32 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL32 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R85 | R85H | COAD | 1 | R85 | R85C | COAD | 1 | P97 | P97L | GBM | 1 | A79 | A79T | KIRC | 1 | H120 | Q118H | LUSC | 1 | R85 | R85H | SKCM | 1 | G142 | Q144H | STAD | 1 | R85 | R85C | UCEC | 1 | H120 | H120Y | UCEC | 1 | R85 | R85H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL32 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H120 | Q118H | -1.2154086 | R85 | R85H | -1.1217464 | R85 | R85C | -0.8502231 | A79 | A79T | -0.41326533 | G142 | Q144H | -0.19918755 | P97 | P97L | -0.15462742 | H120 | H120Y | -0.065448964 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL32 from PDB |
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| Differential gene expression and gene-gene network for MRPL32 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL32 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL32 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL32 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | 0 | A79 R85 P97 H120 G142 |
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| Conservation information for LBS of MRPL32 |
| Multiple alignments for Q9BYC8 in multiple species |
| LBS | AA sequence | # species | Species | A79 | SIFWMAAPKNR | 3 | Homo sapiens, Mus musculus, Bos taurus | A80 | IFWMAAPKNRR | 3 | Homo sapiens, Mus musculus, Bos taurus | C110 | NNIDVCPECGH | 1 | Homo sapiens | C110 | NNIDICPECGH | 1 | Mus musculus | C110 | NNIDFCPECGH | 1 | Bos taurus | C113 | DVCPECGHLKQ | 1 | Homo sapiens | C113 | DICPECGHLKQ | 1 | Mus musculus | C113 | DFCPECGHLKQ | 1 | Bos taurus | C123 | QKHVLCGYCYE | 2 | Mus musculus, Bos taurus | C123 | QKHVLCAYCYE | 1 | Homo sapiens | C126 | VLCGYCYEKVR | 2 | Mus musculus, Bos taurus | C126 | VLCAYCYEKVC | 1 | Homo sapiens | C92 | IEVNRCRRRNP | 3 | Homo sapiens, Mus musculus, Bos taurus | E112 | IDVCPECGHLK | 1 | Homo sapiens | E112 | IDICPECGHLK | 1 | Mus musculus | E112 | IDFCPECGHLK | 1 | Bos taurus | F149 | QEGGPFKAPTI | 1 | Homo sapiens | F149 | QEGGPFRAPSV | 1 | Mus musculus | F149 | QEGGPFKAPTV | 1 | Bos taurus | G142 | IRRQIGKQEGG | 2 | Homo sapiens, Bos taurus | G142 | IRQQIGAQEGG | 1 | Mus musculus | H120 | HLKQKHVLCGY | 2 | Mus musculus, Bos taurus | H120 | HLKQKHVLCAY | 1 | Homo sapiens | I141 | EIRRQIGKQEG | 2 | Homo sapiens, Bos taurus | I141 | KIRQQIGAQEG | 1 | Mus musculus | I87 | KNRRTIEVNRC | 2 | Homo sapiens, Mus musculus | I87 | KNRRSIEVNRC | 1 | Bos taurus | K82 | WMAAPKNRRTI | 2 | Homo sapiens, Mus musculus | K82 | WMAAPKNRRSI | 1 | Bos taurus | K99 | RRNPQKLIKVK | 1 | Homo sapiens | K99 | RRNPQKLIKIK | 1 | Mus musculus | K99 | RRNPHKLIKVK | 1 | Bos taurus | N106 | IKVKNNIDVCP | 1 | Homo sapiens | N106 | IKIKNNIDICP | 1 | Mus musculus | N106 | IKVKNNIDFCP | 1 | Bos taurus | N83 | MAAPKNRRTIE | 2 | Homo sapiens, Mus musculus | N83 | MAAPKNRRSIE | 1 | Bos taurus | N90 | RTIEVNRCRRR | 2 | Homo sapiens, Mus musculus | N90 | RSIEVNRCRRR | 1 | Bos taurus | N96 | RCRRRNPQKLI | 2 | Homo sapiens, Mus musculus | N96 | RCRRRNPHKLI | 1 | Bos taurus | P81 | FWMAAPKNRRT | 2 | Homo sapiens, Mus musculus | P81 | FWMAAPKNRRS | 1 | Bos taurus | P97 | CRRRNPQKLIK | 2 | Homo sapiens, Mus musculus | P97 | CRRRNPHKLIK | 1 | Bos taurus | Q98 | RRRNPQKLIKV | 1 | Homo sapiens | Q98 | RRRNPQKLIKI | 1 | Mus musculus | Q98 | RRRNPHKLIKV | 1 | Bos taurus | R138 | ETAEIRRQIGK | 2 | Homo sapiens, Bos taurus | R138 | ETTKIRQQIGA | 1 | Mus musculus | R139 | TAEIRRQIGKQ | 2 | Homo sapiens, Bos taurus | R139 | TTKIRQQIGAQ | 1 | Mus musculus | R84 | AAPKNRRTIEV | 2 | Homo sapiens, Mus musculus | R84 | AAPKNRRSIEV | 1 | Bos taurus | R85 | APKNRRTIEVN | 2 | Homo sapiens, Mus musculus | R85 | APKNRRSIEVN | 1 | Bos taurus | R91 | TIEVNRCRRRN | 2 | Homo sapiens, Mus musculus | R91 | SIEVNRCRRRN | 1 | Bos taurus | R93 | EVNRCRRRNPQ | 2 | Homo sapiens, Mus musculus | R93 | EVNRCRRRNPH | 1 | Bos taurus | R94 | VNRCRRRNPQK | 2 | Homo sapiens, Mus musculus | R94 | VNRCRRRNPHK | 1 | Bos taurus | R95 | NRCRRRNPQKL | 2 | Homo sapiens, Mus musculus | R95 | NRCRRRNPHKL | 1 | Bos taurus | T86 | PKNRRTIEVNR | 2 | Homo sapiens, Mus musculus | T86 | PKNRRSIEVNR | 1 | Bos taurus | V89 | RRTIEVNRCRR | 2 | Homo sapiens, Mus musculus | V89 | RRSIEVNRCRR | 1 | Bos taurus |
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