mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL32
Gene summary
Basic gene Info.Gene symbolMRPL32
Gene namemitochondrial ribosomal protein L32
SynonymsL32mt|MRP-L32|bMRP-59b
CytomapUCSC genome browser: 7p14
Type of geneprotein-coding
RefGenesNM_031903.2,
Description39S ribosomal protein L32, mitochondrial
Modification date20141207
dbXrefs MIM : 611839
HGNC : HGNC
Ensembl : ENSG00000106591
HPRD : 14752
Vega : OTTHUMG00000155180
ProteinUniProt: Q9BYC8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL32
BioGPS: 64983
PathwayNCI Pathway Interaction Database: MRPL32
KEGG: MRPL32
REACTOME: MRPL32
Pathway Commons: MRPL32
ContextiHOP: MRPL32
ligand binding site mutation search in PubMed: MRPL32
UCL Cancer Institute: MRPL32
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL32

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R85R85HCOAD1
R85R85CCOAD1
P97P97LGBM1
A79A79TKIRC1
H120Q118HLUSC1
R85R85HSKCM1
G142Q144HSTAD1
R85R85CUCEC1
H120H120YUCEC1
R85R85HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL32
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H120Q118H-1.2154086
R85R85H-1.1217464
R85R85C-0.8502231
A79A79T-0.41326533
G142Q144H-0.19918755
P97P97L-0.15462742
H120H120Y-0.065448964
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL32 from PDB

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Differential gene expression and gene-gene network for MRPL32
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL32 and the right PPI network was created from samples without mutations in the LBS of MRPL32. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL32
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL32
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL32 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7y0A79 R85 P97 H120 G142


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Conservation information for LBS of MRPL32
Multiple alignments for Q9BYC8 in multiple species
LBSAA sequence# speciesSpecies
A79SIFWMAAPKNR3Homo sapiens, Mus musculus, Bos taurus
A80IFWMAAPKNRR3Homo sapiens, Mus musculus, Bos taurus
C110NNIDVCPECGH1Homo sapiens
C110NNIDICPECGH1Mus musculus
C110NNIDFCPECGH1Bos taurus
C113DVCPECGHLKQ1Homo sapiens
C113DICPECGHLKQ1Mus musculus
C113DFCPECGHLKQ1Bos taurus
C123QKHVLCGYCYE2Mus musculus, Bos taurus
C123QKHVLCAYCYE1Homo sapiens
C126VLCGYCYEKVR2Mus musculus, Bos taurus
C126VLCAYCYEKVC1Homo sapiens
C92IEVNRCRRRNP3Homo sapiens, Mus musculus, Bos taurus
E112IDVCPECGHLK1Homo sapiens
E112IDICPECGHLK1Mus musculus
E112IDFCPECGHLK1Bos taurus
F149QEGGPFKAPTI1Homo sapiens
F149QEGGPFRAPSV1Mus musculus
F149QEGGPFKAPTV1Bos taurus
G142IRRQIGKQEGG2Homo sapiens, Bos taurus
G142IRQQIGAQEGG1Mus musculus
H120HLKQKHVLCGY2Mus musculus, Bos taurus
H120HLKQKHVLCAY1Homo sapiens
I141EIRRQIGKQEG2Homo sapiens, Bos taurus
I141KIRQQIGAQEG1Mus musculus
I87KNRRTIEVNRC2Homo sapiens, Mus musculus
I87KNRRSIEVNRC1Bos taurus
K82WMAAPKNRRTI2Homo sapiens, Mus musculus
K82WMAAPKNRRSI1Bos taurus
K99RRNPQKLIKVK1Homo sapiens
K99RRNPQKLIKIK1Mus musculus
K99RRNPHKLIKVK1Bos taurus
N106IKVKNNIDVCP1Homo sapiens
N106IKIKNNIDICP1Mus musculus
N106IKVKNNIDFCP1Bos taurus
N83MAAPKNRRTIE2Homo sapiens, Mus musculus
N83MAAPKNRRSIE1Bos taurus
N90RTIEVNRCRRR2Homo sapiens, Mus musculus
N90RSIEVNRCRRR1Bos taurus
N96RCRRRNPQKLI2Homo sapiens, Mus musculus
N96RCRRRNPHKLI1Bos taurus
P81FWMAAPKNRRT2Homo sapiens, Mus musculus
P81FWMAAPKNRRS1Bos taurus
P97CRRRNPQKLIK2Homo sapiens, Mus musculus
P97CRRRNPHKLIK1Bos taurus
Q98RRRNPQKLIKV1Homo sapiens
Q98RRRNPQKLIKI1Mus musculus
Q98RRRNPHKLIKV1Bos taurus
R138ETAEIRRQIGK2Homo sapiens, Bos taurus
R138ETTKIRQQIGA1Mus musculus
R139TAEIRRQIGKQ2Homo sapiens, Bos taurus
R139TTKIRQQIGAQ1Mus musculus
R84AAPKNRRTIEV2Homo sapiens, Mus musculus
R84AAPKNRRSIEV1Bos taurus
R85APKNRRTIEVN2Homo sapiens, Mus musculus
R85APKNRRSIEVN1Bos taurus
R91TIEVNRCRRRN2Homo sapiens, Mus musculus
R91SIEVNRCRRRN1Bos taurus
R93EVNRCRRRNPQ2Homo sapiens, Mus musculus
R93EVNRCRRRNPH1Bos taurus
R94VNRCRRRNPQK2Homo sapiens, Mus musculus
R94VNRCRRRNPHK1Bos taurus
R95NRCRRRNPQKL2Homo sapiens, Mus musculus
R95NRCRRRNPHKL1Bos taurus
T86PKNRRTIEVNR2Homo sapiens, Mus musculus
T86PKNRRSIEVNR1Bos taurus
V89RRTIEVNRCRR2Homo sapiens, Mus musculus
V89RRSIEVNRCRR1Bos taurus


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